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硫鸟嘌呤-thioguanine
记事
The intrinsic clearance value (Vmax/Km) was 0.40 +/- 0.05 ml/min/mg prot for *16 vs. 1.25 +/- 0.09 for *1. The TPMT *16 cDNA was derived from site-directed mutagenesis of "wild-type" TPMT cDNA.
专家论述
TPMT *16 is associated with decreased clearance of thioguanine in artificial constructs expressed in yeast cells as compared to TPMT *1.