注释ID

1184653737

变量_单倍型

CYP2C19*1, CYP2C19*11

基因

CYP2C19

药物名称(英)

mephenytoin

药物名称(中)

苯妥英钠

PMID

12464799

类型

Metabolism/PK

含义

no

记事

Genomic DNA was prepared from 92 different lymphoblastoid cell lines from healthy volunteers (Coriell Genetic Cell Repositories). Each exon, intron-exon junction, and -1.46 kb of the upstream region of CYP2C19 was amplified and products were directly sequenced. "Novel" SNPs were then introduced into plasmids with regions of cDNA flanking the mutated nucleotides were excised and subcloned into new pCW 2C191.B plasmid, transfected into E. coli, expressed and purified. Variant proteins were then assayed for catalytic activity on mephenytoin.

专家论述

CYP2C19 *11 is not associated with decreased activity of CYP2C19 when exposed to mephenytoin as compared to CYP2C19 *1.

等位基因

*11

专家评论

变体注释摘要

id	研究类型	特征类型
26747		Drug