当前位置：药药网 / 数据中心 /变体注释摘要_体外和功能分析类型
巯基嘌呤-mercaptopurine
记事
Note that this * allele was listed by its rsID rs1800462 in the paper (G>C change on negative chromosomal strand). The TPMT nomenclature committee designated this SNP as TPMT*2. There were two *2 alleles in a cohort of 253 subjects. Activity for the *1/*1 group was 88.14 +/- 36.10 and for the *1/*2 group, it was 51.6 +/- 20.51. p value is uncorrected.
专家论述
TPMT *1/*2 is associated with decreased enzyme activity of TPMT when assayed with mercaptopurine in erythrocytes as compared to TPMT *1/*1.