巯基嘌呤-mercaptopurine
注释ID
1184642800
变量_单倍型
TPMT*1, TPMT*2
基因
TPMT
药物名称(英)
mercaptopurine
药物名称(中)
巯基嘌呤
PMID
18605963
类型
Metabolism/PK
含义
no
记事
Note that this * allele was listed by its rsID rs1800462 in the paper (G>C change on negative chromosomal strand). The TPMT nomenclature committee designated this SNP as TPMT*2. There were two *2 alleles in a cohort of 253 subjects. Activity for the *1/*1 group was 88.14 +/- 36.10 and for the *1/*2 group, it was 51.6 +/- 20.51. p value is uncorrected.
专家论述
TPMT *1/*2 is associated with decreased enzyme activity of TPMT when assayed with mercaptopurine in erythrocytes as compared to TPMT *1/*1.
等位基因
*1/*2
专家评论
变体注释摘要
id研究类型特征类型
27043 cohort Study Cohort
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