注释ID

1184643223

变量_单倍型

CYP2C19*1, CYP2C19*19

基因

CYP2C19

药物名称(英)

omeprazole

药物名称(中)

奥美拉唑

PMID

18312490

类型

Metabolism/PK

含义

no

记事

Comparison was to construct the has Ile331Val. Article states CYP2C19.1B having Ile331Val-however, according to definition would be *1C. Activity (hydroxylation of 2 micro moles of omeprazole) was assayed relative to level of holoprotein as well as holo and apoforms of CYP2C19*19 protein in yeast microsomes heterologously expressing CYP2C19*19. Activity is presented as % activity relative to CYP2C19*1B.

专家论述

CYP2C19 *19 is associated with increased activity of CYP2C19 when exposed to omeprazole as compared to CYP2C19 *1.

等位基因

*19

专家评论

变体注释摘要

id	研究类型	特征类型
27042		Drug