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奥美拉唑-omeprazole
变量_单倍型
CYP2C19*1, CYP2C19*19
记事
Comparison was to construct the has Ile331Val. Article states CYP2C19.1B having Ile331Val-however, according to definition would be *1C. Activity (hydroxylation of 2 micro moles of omeprazole) was assayed relative to level of holoprotein as well as holo and apoforms of CYP2C19*19 protein in yeast microsomes heterologously expressing CYP2C19*19. Activity is presented as % activity relative to CYP2C19*1B.
专家论述
CYP2C19 *19 is associated with increased activity of CYP2C19 when exposed to omeprazole as compared to CYP2C19 *1.