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变量_单倍型
TPMT*1, TPMT*2, TPMT*3A, TPMT*3B
记事
When TPMT*2 cDNAs were expressed in yeast, levels of TPMT*2 protein were 20-fold less than TPMT*1. Levels of TPMT*3A were 200-fold less. Levels of TPMT*3B were 4-fold less. Levels of TPMT*3C were similar to wild type. Comparable results were obtained in COS-1 cells. TPMT*2, *3A and *3B also had decreased degradation half-lives as compared to *1 in yeast. Note that mRNA levels were comparable between these alleles in yeast.
专家论述
TPMT *2 + *3A + *3B is associated with decreased steady-state level of TPMT protein as compared to TPMT *1.