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睾酮-testosterone
记事
Authors state "The CYP3A5 R28C allele exhibited significantly lower catalytic activity compared to CYP3A51 for testosterone 6- and 2-hydroxylation. CYP3A5 R28C exhibited 68 and 43% decreases in the maximal clearances of 6- hydroxytestosterone." Mapped using PharmVar.
专家论述
Allele A is associated with decreased enzyme activity of CYP3A5 when assayed with testosterone as compared to allele G.