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“咖啡因”、“氟烷”-"caffeine","halothane"
药物名称(英)
"caffeine","halothane"
记事
The authors used muscle strips from patient biopsies (from in vitro contracture tests) to compare the threshold concentration of caffeine and halothane needed to generate 0.2 g force in muscle strips. They also compared the tension generated in the same muscle a the same concentrations of caffeine and halothane (2 mM). In all cases, muscles carrying the malignant hyperthermia susceptibility (MHS)-causative variant demonstrated greater sensitivity to halothane than caffeine. Homozygous MHS individuals were excluded from analyses.
专家论述
Genotype CT is associated with sensitivity to caffeine or halothane in muscle.