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“咖啡因”、“氟烷”-"caffeine","halothane"
药物名称(英)
"caffeine","halothane"
记事
The authors used muscle strips from patient biopsies (from in vitro contracture tests) to compare the threshold concentration of caffeine and halothane needed to generate 0.2 g force in muscle strips. They also compared the tension generated in the same muscle a the same concentrations of caffeine and halothane (2 mM) .In all cases, muscles carrying the malignant hyperthermia susceptibility (MHS)-causative variant demonstrated greater sensitivity to halothane than caffeine. Homozygous MHS individuals were excluded from analyses.
专家论述
Genotype AG is associated with sensitivity to caffeine or halothane in muscle as compared to genotype GG.