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硝苯地平-nifedipine
记事
Authors state "This mutation affected nifedipine metabolism, producing a 64% decrease in the Vmax but a 13% increase in intrinsic clearance compared to CYP3A51." Mapped using PharmVar.
专家论述
Allele A is associated with decreased enzyme activity of CYP3A5 when assayed with nifedipine as compared to allele G.