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酮洛芬-ketoprofen
记事
Genotype CC is associated with increased postoperative pain relief on postoperative day 3 when treated with ketoprofen as compared to genotype CT. No significant differences were found on postoperative days 1, 2, 4, and 5. rs1799853 C>T is the defining variant of CYP2C9*2. The direction of this association conflicts with the direction found for the CYP2C9*3 genotype in the same study. In a personal communication, the corresponding author states that the postoperative day 3 effect may be due to secondary hyperalgesia. The study population only contained heterozygous individuals; the authors did not report the number of individuals who were heterozygous for both the *2 and *3 defining variants. In a personal communication, the corresponding author stated that one individual was heterozygous for both rs1799853 and rs1057910; the variants were not phased.
专家论述
Genotype CC is associated with increased response to ketoprofen in people with Pain, Postoperative as compared to genotype CT.