注释ID

1451771820

变量_单倍型

rs416593

基因

UGT2B@

药物名称(英)

clozapine N+ glucuronide

药物名称(中)

氯氮平 N+ 葡萄糖苷酸

PMID

35105285

类型

Metabolism/PK

含义

no

记事

in patients receiving clozapine subjected to routine therapeutic drug monitoring, as part of a haplotype of rs1513559 and rs416593. "Compared to UGT2B:AT/AT carriers, UGT2B:GA/GA and UGT2B:GA/AT carriers had 70% and 50% (UGT2B:GA/GA vs UGT2B:AT/AT: 0.045 vs 0.15 nM/mg, p=0.021; UGT2B:GA/ATvs UGT2B:AT/AT: 0.076vs 0.15nM/mg, p=0.016; table 2 and supplementary table 1) reduced CD ratios of CLZ N+-glucuronide levels, respectively"

专家论述

Genotypes AA + AT is associated with decreased exposure to clozapine N+ glucuronide as compared to genotype AA.

等位基因

AA + AT

专家评论

备注

变体注释摘要

id	研究类型	特征类型
17915		Study Cohort