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氯氮平 5-N-葡糖苷酸-clozapine 5-N-glucuronide
药物名称(英)
clozapine 5-N-glucuronide
记事
in patients receiving clozapine subjected to routine therapeutic drug monitoring. Authors map rs2011425T>G to UGT1A4*3, and report no *3/*3 (GG) homozygotes in the study group. "Compared to noncarriers, UGT1A4*3 carriers had a nominally increasedCD ratio ofCLZ 5N-glucuronide by 100%, but this effect was not significant"
专家论述
Genotype GT is associated with decreased exposure to clozapine 5-N-glucuronide as compared to genotype TT.