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甲氨蝶呤-methotrexate
记事
our results show that MTX clearance was significantly influenced by genetic polymorphisms. We found that two single nucleotide polymorphisms (SNPs) in two genes were significantly associated with MTX clearance: rs4148416 in ABCC3 and rs17004785 in SLC19A1.
专家论述
Genotype CG is associated with increased clearance of methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype GG.