当前位置：药药网 / 数据中心 /变体注释摘要_药物剂量、反应、代谢
巯基嘌呤-mercaptopurine
记事
Authors stated "Although no statistically significant associations were identified... In the case of rs1800460, of the six heterozygous patients, three required a dosage decrease, and two were also heterozygous for rs1142345." No TT homozygotes were observed. "Studies with a larger population size are needed"
专家论述
Genotype CT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.