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甲氨蝶呤-methotrexate
记事
dose-adjusted serum concentrations at 24 hours were significant but not at 48 hours. This was also associated with risk of relapse as part of a haplotype of 5 variants in MTRR (MTRR rs1801394 A>G, rs1532268 C>T, rs162036 A>G, rs10380 C>T, and rs9332 C>T).
专家论述
Genotypes CT + TT is associated with increased exposure to methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.