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SN-38-SN-38
记事
This refers to reduced metabolism of the SN-38 metabolite into the inactive SN-38G form by UGT1A1. Patients homozygous for the A allele had increased exposure to SN-38, increased biliary index values and decreased relative extent of glucuronidation (please see study parameters for further description of these measurements). Irinotecan was given once every three weeks in a 375 mg/m2 dose, and neoplasms included nasopharyngeal carcinoma (n=1), gastrointestinal (n=35), genitourinary (n=2), non-small-cell lung cancer (n=5) and miscellaneous (n=2).
专家论述
Genotype AA is associated with decreased metabolism of SN-38 in people with Neoplasms as compared to genotype GG.