注释ID

981476160

变量_单倍型

NAT2*4, NAT2*5A, NAT2*6B, NAT2*7A, NAT2*12A, NAT2*13A, NAT2*14A

基因

NAT2

药物名称(英)

isoniazid

药物名称(中)

异烟肼

PMID

21558457

类型

Metabolism/PK

含义

not stated

记事

Fast acetylators (two fast alleles NAT2*4, *12, *13) were grouped together, compared to intermediate (one fast and one slow allele) and slow acetylators (two slow alleles NAT2*5, *6, *7, *14) in an analysis of clearance of isoniazid in infants over time from 3 months old to 24 months (normalized for 70kg body weight). Fast acetylators displayed an increase in clearance over this time period, also seen in intermediate acetylators but in slow acetylators clearance remained constant over time.

专家论述

NAT2 *5A + *6B + *7A + *14A is associated with decreased clearance of isoniazid in children with HIV Infections as compared to NAT2 *4 + *12A + *13A.

等位基因

*5A + *6B + *7A + *14A

专家评论

Pediatric

备注

变体注释摘要

id	研究类型	特征类型
17884	clinical trial	Study Cohort