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利培酮-risperidone
记事
good response = 50% reduction in PANSS score. Authors state "The result showed that rs2088885 was associated with antipsychotic drug responses under codominant, recessive and log-additive genetic models (p = 0.021; p = 0.008; and p = 0.013, respectively). In the best model (recessive), genotype A/A was more prevalent in good responders than in poor responders (C/C + C/A C/T vs A/A" however later in the discussion they state "Patients that carried the C allele (p = 0.022) or the CC genotype (p = 0.036) of the TNIK rs2088885 polymorphism were more likely to respond to antipsychotic drug treatment."
专家论述
Genotype AA is associated with increased response to risperidone in people with Schizophrenia as compared to genotypes AC + CC.