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肼屈嗪-hydralazine
变量_单倍型
NAT2 rapid acetylator
记事
Note, NAT2 not specified just categorized in slow and rapid acetylator. Acetylation phenotype, as determined by sulfamethazine acetylation rate, was an important determinant of the plasma level of hydralazine. Fast acetylators also required significantly higher doses of hydralazine for adequate blood pressure control than did slow acetylators. In contrast, the mean plasma concentration of hydralazine which produced a satisfactory blood pressure reduction was the same in both groups.
专家论述
NAT2 rapid acetylator is associated with increased dose of hydralazine in people with Hypertension as compared to NAT2 slow acetylator.