注释ID

1183702439

变量_单倍型

NAT2*4, NAT2*5A, NAT2*6B, NAT2*7A

基因

NAT2

药物名称(英)

isoniazid

药物名称(中)

异烟肼

PMID

24383060

类型

Metabolism/PK

含义

yes

记事

Slow acetylators (a combination of two slow alleles NAT2*5, *6 or *7) had higher isoniazid plasma concentrations and bioavailability compared to rapid (*4/*4) and intermediate acetylators (*4 allele combined with *5, *6 or *7). Patients with *7/*7 genotype had the highest levels. Authors report "To identify the three NAT2* mutations, C481T (NAT2*5), G590A (NAT2*6), and G857A (NAT2*7)"

专家论述

NAT2 *5A/*5A + *5A/*6B + *6B/*6B + *6B/*7A + *7A/*7A (assigned as slow acetylator phenotype) is associated with decreased metabolism of isoniazid in people with Tuberculosis as compared to NAT2 *4/*4 (assigned as rapid acetylator phenotype) .

等位基因

*5A/*5A + *5A/*6B + *6B/*6B + *6B/*7A + *7A/*7A

专家评论

备注

变体注释摘要

id	研究类型	特征类型
17869	cohort	Study Cohort