注释ID

1451139042

变量_单倍型

NAT2*5D, NAT2*6B, NAT2*7A, NAT2*14A

基因

NAT2

药物名称(英)

dipyrone

药物名称(中)

安乃近

PMID

25241292

类型

Metabolism/PK

含义

yes

记事

N-demethylation of the active metabolite MAA is diminished in carriers of the CYP2C19*2 allele and in NAT2-slow acetylators. "The inferred slow NAT2 phenotype is strongly associated with a decrease in the acetylation ratio and in the recovery of AAA. This effect is associated to all NAT2 slow alleles analyzed, but a differential effect is observed: Individuals who were homozygous for the NAT2*6 allele displayed a significantly lower AAA recovery and lower acetylation ratio as compared to individuals homozygous for the NAT2*5 allele" Authors used genotyping assays NAT2*5 rs1801280, NAT2*6 rs1799930, NAT2*7 rs1799931, and NAT2*14 rs1801279 mapped here to the suballeles for those rs numbers.

专家论述

NAT2 *5D + *6B + *7A + *14A (assigned as slow acetylator phenotype) are associated with decreased metabolism of dipyrone in healthy individuals.

等位基因

*5D + *6B + *7A + *14A

专家评论

备注

变体注释摘要

id	研究类型	特征类型
17864	cohort	Unknown