咖啡因-caffeine,变体注释摘要_药物剂量、反应、代谢

咖啡因-caffeine

注释ID

1451793682

变量_单倍型

NAT2*4, NAT2*5A, NAT2*5B, NAT2*5C, NAT2*5D, NAT2*6A, NAT2*6B, NAT2*7A, NAT2*7B, NAT2*11A, NAT2*12A, NAT2*12C, NAT2*13, NAT2*13A

基因

NAT2

药物名称(英)

caffeine

药物名称(中)

咖啡因

PMID

17011540

类型

Metabolism/PK

含义

not stated

记事

AFMU/(AFMU+1U+1X) metabolic ratio was measured in urine after caffeine dosage...metabolism of paraxanthine (17X, 1,7-dimethylxanthine) by NAT2 to form AFMU was increased in men with this genotype.

专家论述

NAT2 *4/*5B + *11A/*5C + *12A/*5A + *12C/*5D + *4/*6A + *13/*6B + *4/*7B + *13A/*7A + *13A/*6A (assigned as rapid acetylator phenotype) is associated with increased metabolism of caffeine in men.

等位基因

*4/*5B + *11A/*5C + *12A/*5A + *12C/*5D + *4/*6A + *13/*6B + *4/*7B + *13A/*7A + *13A/*6A

专家评论

备注

变体注释摘要