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尼罗替尼-nilotinib
记事
alleles complimented to plus chromosomal strand. Rs number from PharmVar, effects reported for CYP1A1*2C A>G. Excerpt "wild type CYP1A1, GSTP1 and GSTM1 deletion was significantly frequent in responders. The partial responders carried heterozygous mutant genotypes of CYP1A1"
专家论述
Genotypes CT + TT is associated with increased response to nilotinib in people with Leukemia, Myelogenous, Chronic, BCR-ABL Positive as compared to genotype CC.