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多替拉韦-dolutegravir
变量_单倍型
UGT1A1*1, UGT1A1*6, UGT1A1*28
记事
Pooled samples from three Phase I clinical trials (NCT02219217, NCT02509195 and NCT03094507) and one Phase III clinical trial (NCT02351908) carried out at the St Stephen鈥檚 AIDS Trust clinical trial unit, London
专家论述
UGT1A1 *28/*28 + *6/*6 is associated with increased concentrations of dolutegravir in people with HIV Infections as compared to UGT1A1 *1/*1.