注释ID

1451774660

变量_单倍型

rs2231142

基因

ABCG2

药物名称(英)

dolutegravir

药物名称(中)

多替拉韦

PMID

32011683

类型

Metabolism/PK

含义

yes

记事

Alleles complemented to plus chromosomal strand. "ABCG2 c.421C>A (rs2231142) was independently associated with a 28% increase in dolutegravir Cmax (b = 0.053; P = 0.047) in the homozygous variant. GM Cmax (95% CI) was 3893 (3774鈥?240), 4346 (3629鈥?531) and 4994 (single value) ng/mL in the CC, CA and AA genotype groups, respectively." "Pooled samples from three Phase I clinical trials (NCT02219217, NCT02509195 and NCT03094507) and one Phase III clinical trial (NCT02351908) carried out at the St Stephen鈥檚 AIDS Trust clinical trial unit, London" From Table one, only one individual was homozygous for minor allele.

专家论述

Genotype TT is associated with increased concentrations of dolutegravir in people with HIV Infections as compared to genotypes GG + GT.

等位基因

TT

专家评论

备注

变体注释摘要

id	研究类型	特征类型
17812	clinical trial	Study Cohort