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利尿剂，“氢氯噻嗪”，“普通噻嗪类”-diuretics,"hydrochlorothiazide","Thiazides, plain"
药物名称(英)
diuretics,"hydrochlorothiazide","Thiazides, plain"
药物名称(中)
利尿剂，“氢氯噻嗪”，“普通噻嗪类”
记事
There is potential for strand confusion with a CG SNP, and it is not clear with respect to the positive chromosomal strand which allele is associated with better response. The article text states that no GG were observed, but table 2 lists C as the low frequency allele. The association did not reach genome-wide significance when only PEAR + GERA were analyzed, but this SNP was selected for replication in NORDIL, where the association also did not reach significance. This association approached genome-wide significance in the meta-analysis of PEAR + GERA + NORDIL. Observations: 8.21 mm Hg decrease in reduction of systolic blood pressure per C allele in PEAR + GERA, 7.79 mm Hg decrease in reduction in systolic blood pressure per C allele in NORDIL and 8.15 mm Hg decrease in reduction of systolic blood pressure per C allele in PEAR + GERA + NORDIL.
专家论述
Genotype CG is associated with increased response to diuretics, hydrochlorothiazide or Thiazides, plain in people with Hypertension as compared to genotype CC.