当前位置：药药网 / 数据中心 /变体注释摘要_药物剂量、反应、代谢
利尿剂，“氢氯噻嗪”，“普通噻嗪类”-diuretics,"hydrochlorothiazide","Thiazides, plain"
药物名称(英)
diuretics,"hydrochlorothiazide","Thiazides, plain"
药物名称(中)
利尿剂，“氢氯噻嗪”，“普通噻嗪类”
记事
Observations: 4.46 mm Hg increased reduction of diastolic blood pressure per A allele in PEAR + GERA, 3.26 mm Hg increased reduction of diastolic blood pressure per A allele in NORDIL, and 4.16 mm Hg increased reduction of diastolic blood pressure per A allele in PEAR + GERA + NORDIL.The association did not reach genome-wide significance when only PEAR + GERA were analyzed, but this SNP was selected for replication in NORDIL and here the association reached significance. It did not reach genome-wide significance in the meta-analysis of PEAR + GERA + NORDIL. It was then tested for replication in the GENRES and Milan cohorts, reaching significance in GENRES but not in the Milan cohort.
专家论述
Allele A is associated with increased response to diuretics, hydrochlorothiazide or Thiazides, plain in people with Hypertension as compared to allele G.