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依法韦仑-efavirenz
变量_单倍型
CYP2B6*1, CYP2B6*18
记事
Please note that in the paper the allele was referred to as CYP2B6*16. CYP2B6*16 and *18 alleles have been consolidated by PharmVar in Jan 2020, with *16 now listed as a suballele of *18 (CYP2B6*18.002). This annotation is updated to be on CYP2B6*18, instead of CYP2B6*16.
专家论述
CYP2B6 *1/*18 is associated with increased concentrations of efavirenz in people with HIV Infections as compared to CYP2B6 *1/*1.