注释ID

1183684657

变量_单倍型

CYP2D6 ultrarapid metabolizer genotype

基因

CYP2D6

药物名称(英)

tramadol

药物名称(中)

曲马多

PMID

18204346

类型

Metabolism/PK

含义

yes

记事

Median (+)R,R-tramadol area under the curve was 2386 +/- 681 mg.h.L in PMs and 667 +/- 243 mg.h.L in UMs. Median (-)S,S-tramadol area under the curve was 2370 +/- 631 mg.h.L in PMs and 561 +/- 193 mg.h.L in UMs.The UM group consisted of subjects with one active duplication allele (*1x2,*2x2,*35x2,*41x2) and one active allele (*1,*2,*9,*10,*35,*41). The PM group consisted of subjects with both alleles from the group *3,*4,*5,*6.

专家论述

CYP2D6 ultra-metabolizer genotype is associated with increased metabolism of tramadol in healthy individuals as compared to CYP2D6 poor metabolizer genotype.

等位基因

专家评论

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变体注释摘要

id	研究类型	特征类型
15606	cohort	Study Cohort