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双氯芬酸-diclofenac
变量_单倍型
CYP2C9*1, CYP2C9*3, CYP2C9*8
记事
Healthy individuals with the *1/*3 or *1/*8 genotypes had a higher diclofenac/4'-OH diclofenac metabolite ratio, as compared to those with the *1/*1 genotype. No significant results were seen when considering the diclofenac/3'-OH metabolite ratio, or the diclofenac/5'-OH metabolite ratio. Genotypes were combined by PharmGKB as part of the curation process.
专家论述
CYP2C9 *1/*3 + *1/*8 are associated with decreased metabolism of diclofenac in healthy individuals as compared to CYP2C9 *1/*1.