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二甲双胍-metformin
记事
Subjects were at high risk of diabetes and were recruited from Diabetes Prevention Program (DPP) and were followed for a year. The authors measured changes in response to insulin at baseline and one year after treatment. Although the GG genotype was not associated with response to metformin, it was associated with changes in lifestyle as subjects with that genotype were less likely to develop diabetes compared with persons with the same genotype in the placebo (P=0.02) and metformin (P=0.02) groups.
专家论述
Genotype GG is not associated with response to metformin as compared to genotypes GT + TT.