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二甲双胍-metformin
记事
Subjects were at high risk of diabetes and were recruited from Diabetes Prevention Program (DPP) and were followed for a year. The authors measured changes in response to insulin at baseline and one year after treatment. Subjects with the AA genotypes had the highest diabetes incidence in the placebo group but had a significant response to metformin. Subjects with the AG genotype had lower diabetes incidence rates than subjects with the AA genotype, but incidence of diabetes were significantly associated with lifestyle changes or metformin. Diabetes incidence rates were lower in subjects with the GG genotype with lifestyle intervention (P<0.001) but not by metformin (P=0.2) as compared with placebo.
专家论述
Genotypes AA + AG are associated with increased response to metformin as compared to genotype GG.