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辛伐他汀-simvastatin
记事
as measured by significantly higher plasma simvastatin AUC. 30% of variability in AUC could be explained by the absence/ presence of the CYP3A5*3 allele (allele C) p=0.0084 in regression analysis, remaining significant after adjusting for age. Variant described as CYP3A5 *3 (here represented as allele C), *1 (allele T).
专家论述
Genotype CC is associated with decreased metabolism of simvastatin in healthy individuals as compared to genotype TT.