注释ID

982044179

变量_单倍型

rs2032582

基因

ABCB1

药物名称(英)

digoxin

药物名称(中)

地高辛

PMID

17652833

类型

Metabolism/PK

含义

no

记事

or allele T. For the cohort of patients receiving P-glycoprotein inhibitors (n = 31) or the cohort of patients not receiving inhibitors (n = 46), NOT the combined cohorts. Study subjects were grouped into a CC genotype group, CT + CA genotype group, and AA + AT genotype group. No significant differences in steady-state digoxin serum/saliva concentration ratios were seen between these groups. Please note alleles have been complemented to the plus chromosomal strand.

专家论述

Allele C is not associated with clearance of digoxin in people with Heart Failure as compared to allele A.

等位基因

C

专家评论

备注

变体注释摘要

id	研究类型	特征类型
26040	cohort	Drug