注释ID

1451734560

变量_单倍型

rs12248560

基因

CYP2C19

药物名称(英)

diazepam

药物名称(中)

地西泮

PMID

32134726

类型

Efficacy

含义

yes

记事

Individuals undergoing alcohol withdrawal therapy with diazepam had smaller negative change in CIWA-Ar scores; a smaller decrease indicates lower efficacy. Authors describe effect for *1/*17 and *17/*17 vs *1/*1 but then numbers for *1 vs *2 are different suggesting that they assess rs4244285 and CYP2C19*17, rs12248560 completely separately therefore reporting the effect per the separate rs numbers.

专家论述

Genotypes CT + TT is associated with decreased clinical benefit to diazepam in men with Alcoholism as compared to genotype CC.

等位基因

CT + TT

专家评论

备注

变体注释摘要

id	研究类型	特征类型
17787		Study Cohort