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他克莫司-tacrolimus
类型
Dosage,"Metabolism/PK"
记事
Dose-adjusted trough concentrations were three-fold and 1.6-fold higher in CYP3A5*3/*3 (CC) subjects than in CYP3A5*1/*3 (CT) subjects as compared to CYP3A5*1/*1 (TT). As a result, the dose of tacrolimus required to reach the target tacrolimus concentration was the lowest for the CC genotype, followed by the CT and then TT genotype.
专家论述
Genotype CC is associated with decreased dose of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.