注释ID

1451734503

变量_单倍型

rs4244285

基因

CYP2C19

药物名称(英)

diazepam

药物名称(中)

地西泮

PMID

32134726

类型

Efficacy

含义

yes

记事

Individuals undergoing alcohol withdrawal therapy with diazepam had larger negative change in CIWA-Ar scores; a larger decrease indicates higher efficacy. Authors describe effect for *1/*2 and *2/*2 vs *1/*1 but then numbers for *1 vs *17 are different suggesting that they assess rs4244285 and CYP2C19*17, rs12248560 completely separately therefore reporting the effect per the separate rs numbers.

专家论述

Genotypes AA + AG is associated with increased clinical benefit to diazepam in men with Alcoholism as compared to genotype GG.

等位基因

AA + AG

专家评论

备注

变体注释摘要

id	研究类型	特征类型
17786		Study Cohort