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尼古丁-nicotine
变量_单倍型
CYP2A6*1A, CYP2A6*1B1, CYP2A6*2, CYP2A6*4A, CYP2A6*9, CYP2A6*12, CYP2A6*17, CYP2A6*20, CYP2A6*23, CYP2A6*24A, CYP2A6*25, CYP2A6*26, CYP2A6*27, CYP2A6*28A, CYP2A6*35
记事
Please note that the *46 allele is described as the *1B1 allele in the paper and has subsequently been reassigned by PharmVar.
专家论述
CYP2A6 *1A/*2 + *1A/*4A + *1A/*9 + *1A/*12 + *1A/*17 + *1A/*20 + *1A/*23 + *1A/*24A + *1A/*25 + *1A/*26 + *1A/*27 + *1A/*28A + *1A/*35 + *9/*9 + *17/*17 + *20/*20 + *35/*35 (assigned as intermediate and low activity phenotype) are associated with decreased metabolism of nicotine as compared to CYP2A6 *1A/*1A +*1A/*46 + *46/*46 (assigned as normal metabolizer phenotype) .
等位基因
*1A/*2 + *1A/*4A + *1A/*9 + *1A/*12 + *1A/*17 + *1A/*20 + *1A/*23 + *1A/*24A + *1A/*25 + *1A/*26 + *1A/*27 + *1A/*28A + *1A/*35 + *9/*9 + *17/*17 + *20/*20 + *35/*35