创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:48:16 UTC
描述
Deoxyguanosine, also known as dG, belongs to the class of organic compounds known as purine 2'-deoxyribonucleosides. Purine 2'-deoxyribonucleosides are compounds consisting of a purine linked to a ribose which lacks a hydroxyl group at position 2’. Deoxyguanosine is a nucleoside consisting of the base guanine and the sugar deoxyribose. Deoxyguanosine is one of the four deoxyribonucleosides that make up DNA. Deoxyguanosine exists in all living species, ranging from bacteria to plants to humans. Deoxyguanosine participates in a number of enzymatic reactions. In particular, deoxyguanosine can be biosynthesized from 2'-deoxyguanosine 5'-monophosphate through the enzyme known as cytosolic purine 5'-nucleotidase. In addition, deoxyguanosine can be converted into 2'-deoxyguanosine 5'-monophosphate (dGMP); which is mediated by the enzyme deoxyguanosine kinase. Deoxyguanosine is involved in the rare, inherited metabolic disorder called the purine nucleoside phosphorylase deficiency (PNP deficiency). In particular PNP deficiency is characterized by elevated levels of dGTP (deoxyguanosine triphosphate). PNP accounts for approximately 4% of patients with severe combined immunodeficiency (PMID: 1931007). PNP-deficient patients suffer from recurrent infections, usually beginning in the first year of life. Two thirds of patients have evidence of neurologic disorders with spasticity, developmental delay and mental retardation. Deoxyguanosine can be converted to 8-hydroxy-deoxyguanosine (8-OHdG) due to hydroxyl radical attack at the C8 of guanine. 8-hydroxy-deoxyguanosine is a sensitive marker of the DNA damage This damage, if left unrepaired, has been proposed to contribute to mutagenicity and cancer promotion.
同义词
1:2-Amino-9-(2-deoxy-9-beta-D-ribofuranosyl)-9H-purin-6-ol
2:9-(2-Deoxy-beta-D-erythro-pentofuranosyl)-guanine
3:dG
4:Guanine deoxy nucleoside
5:2'-Deoxyguanosine
6:2-Amino-9-(2-deoxy-9-b-D-ribofuranosyl)-9H-purin-6-ol
7:2-Amino-9-(2-deoxy-9-β-D-ribofuranosyl)-9H-purin-6-ol
8:9-(2-Deoxy-b-D-erythro-pentofuranosyl)-guanine
9:9-(2-Deoxy-β-D-erythro-pentofuranosyl)-guanine
10:2'-Deoxy-guanosine
11:2-Deoxyguanosine
12:9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine
13:9-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-guanine
14:9-(2-Deoxy-beta-delta-erythro-pentofuranosyl)guanine
15:Desoxyguanosine
16:Guanine deoxyriboside
17:Deoxyguanosine
化学名称
2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
代谢物结构字符串
NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)N1
inchi标识符
InChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1
印记键
YKBGVTZYEHREMT-KVQBGUIXSA-N
分类学
description: belongs to the class of organic compounds known as purine 2'-deoxyribonucleosides. Purine 2'-deoxyribonucleosides are compounds consisting of a purine linked to a ribose which lacks a hydroxyl group at position 2.
description:Purine 2'-deoxyribonucleosides
kingdom:Organic compounds
super_class:Nucleosides, nucleotides, and analogues
class:Purine nucleosides
sub_class:Purine 2'-deoxyribonucleosides
molecular_framework:Aromatic heteropolycyclic compounds
1:6-oxopurines
2:Aminopyrimidines and derivatives
3:Azacyclic compounds
4:Heteroaromatic compounds
5:Hydrocarbon derivatives
6:Hypoxanthines
7:N-substituted imidazoles
8:Organic oxides
9:Organopnictogen compounds
10:Oxacyclic compounds
11:Primary alcohols
12:Primary amines
13:Pyrimidones
14:Secondary alcohols
15:Tetrahydrofurans
16:Vinylogous amides
17:6-oxopurine
18:Alcohol
19:Amine
20:Aminopyrimidine
21:Aromatic heteropolycyclic compound
22:Azacycle
23:Azole
24:Heteroaromatic compound
25:Hydrocarbon derivative
26:Hypoxanthine
27:Imidazole
28:Imidazopyrimidine
29:N-substituted imidazole
30:Organic nitrogen compound
31:Organic oxide
32:Organic oxygen compound
33:Organoheterocyclic compound
34:Organonitrogen compound
35:Organooxygen compound
36:Organopnictogen compound
37:Oxacycle
38:Primary alcohol
39:Primary amine
40:Purine
41:Purine 2'-deoxyribonucleoside
42:Purinone
43:Pyrimidine
44:Pyrimidone
45:Secondary alcohol
46:Tetrahydrofuran
47:Vinylogous amide
48:Deoxyribonucleosides
49:purine 2'-deoxyribonucleoside
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:All tissues
definition:All tissues in the body of the organism.
parent_id:7729
***level:4
type:child
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Mitochondria
definition:
parent_id:7730
***level:4
type:child
term:Nucleus
definition:A body within the cell, surrounded by a membrane, within which lie the chromosomes, one or more nucleoli, combined with proteins, and exhibits mitosis. (NCI)
parent_id:7730
***level:4
type:child
synonym:Cell nucleus
synonym:Nucleic
term:Lysosome
definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).
parent_id:7730
***level:4
type:child
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
实验性质
1:
kind:logp
value:-1.30
source:BALZARINI,JM ET AL. (1989)
2:
kind:melting_point
value:300 °C
source:
预测性质
1:
kind:logp
value:-1.75
source:ALOGPS
2:
kind:logs
value:-1.37
source:ALOGPS
3:
kind:solubility
value:11.5 g/L
source:ALOGPS
4:
kind:logp
value:-1.8
source:ChemAxon
5:
kind:pka_strongest_acidic
value:10.16
source:ChemAxon
6:
kind:pka_strongest_basic
value:0.46
source:ChemAxon
7:
kind:iupac
value:2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
source:ChemAxon
8:
kind:average_mass
value:267.2413
source:ChemAxon
9:
kind:mono_mass
value:267.096753929
source:ChemAxon
10:
kind:smiles
value:NC1=NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)N1
source:ChemAxon
11:
kind:formula
value:C10H13N5O4
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1
source:ChemAxon
13:
kind:inchikey
value:YKBGVTZYEHREMT-KVQBGUIXSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:134.99
source:ChemAxon
15:
kind:refractivity
value:63.11
source:ChemAxon
16:
kind:polarizability
value:25.24
source:ChemAxon
17:
kind:rotatable_bond_count
value:2
source:ChemAxon
18:
kind:acceptor_count
value:7
source:ChemAxon
19:
kind:donor_count
value:4
source:ChemAxon
20:
kind:physiological_charge
value:0
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:3
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::NmrTwoD
spectrum_id:951
2:
type:Specdb::NmrTwoD
spectrum_id:1133
3:
type:Specdb::MsMs
spectrum_id:135
4:
type:Specdb::MsMs
spectrum_id:136
5:
type:Specdb::MsMs
spectrum_id:137
6:
type:Specdb::MsMs
spectrum_id:2795
7:
type:Specdb::MsMs
spectrum_id:2796
8:
type:Specdb::MsMs
spectrum_id:2797
9:
type:Specdb::MsMs
spectrum_id:2798
10:
type:Specdb::MsMs
spectrum_id:2799
11:
type:Specdb::MsMs
spectrum_id:2800
12:
type:Specdb::MsMs
spectrum_id:2801
13:
type:Specdb::MsMs
spectrum_id:2802
14:
type:Specdb::MsMs
spectrum_id:2803
15:
type:Specdb::MsMs
spectrum_id:2804
16:
type:Specdb::MsMs
spectrum_id:2805
17:
type:Specdb::MsMs
spectrum_id:2806
18:
type:Specdb::MsMs
spectrum_id:178617
19:
type:Specdb::MsMs
spectrum_id:178618
20:
type:Specdb::MsMs
spectrum_id:178619
21:
type:Specdb::MsMs
spectrum_id:180936
22:
type:Specdb::MsMs
spectrum_id:180937
23:
type:Specdb::MsMs
spectrum_id:180938
24:
type:Specdb::MsMs
spectrum_id:437559
25:
type:Specdb::MsMs
spectrum_id:437560
26:
type:Specdb::MsMs
spectrum_id:437561
27:
type:Specdb::MsMs
spectrum_id:437562
28:
type:Specdb::NmrOneD
spectrum_id:1075
29:
type:Specdb::NmrOneD
spectrum_id:4902
30:
type:Specdb::NmrOneD
spectrum_id:5652
31:
type:Specdb::NmrOneD
spectrum_id:5653
32:
type:Specdb::NmrOneD
spectrum_id:5654
33:
type:Specdb::NmrOneD
spectrum_id:5655
34:
type:Specdb::NmrOneD
spectrum_id:5656
35:
type:Specdb::NmrOneD
spectrum_id:5657
36:
type:Specdb::NmrOneD
spectrum_id:5658
37:
type:Specdb::NmrOneD
spectrum_id:5659
38:
type:Specdb::NmrOneD
spectrum_id:5660
39:
type:Specdb::NmrOneD
spectrum_id:5661
40:
type:Specdb::NmrOneD
spectrum_id:5662
41:
type:Specdb::NmrOneD
spectrum_id:5663
42:
type:Specdb::NmrOneD
spectrum_id:5664
43:
type:Specdb::NmrOneD
spectrum_id:5665
44:
type:Specdb::NmrOneD
spectrum_id:5666
45:
type:Specdb::NmrOneD
spectrum_id:5667
46:
type:Specdb::NmrOneD
spectrum_id:5668
47:
type:Specdb::NmrOneD
spectrum_id:5669
48:
type:Specdb::NmrOneD
spectrum_id:5670
49:
type:Specdb::NmrOneD
spectrum_id:5671
50:
type:Specdb::CMs
spectrum_id:316
51:
type:Specdb::CMs
spectrum_id:2119
52:
type:Specdb::CMs
spectrum_id:2122
53:
type:Specdb::CMs
spectrum_id:2656
54:
type:Specdb::CMs
spectrum_id:30422
55:
type:Specdb::CMs
spectrum_id:30989
56:
type:Specdb::CMs
spectrum_id:30990
57:
type:Specdb::CMs
spectrum_id:37286
58:
type:Specdb::CMs
spectrum_id:168402
生物学性质
1:
cellular:(1):Cytoplasm
cellular:(2):Extracellular
cellular:(3):Lysosome
cellular:(4):Mitochondria
cellular:(5):Nucleus
2:
biospecimen:(1):Blood
biospecimen:(2):Feces
biospecimen:(3):Saliva
biospecimen:(4):Urine
3:
tissue:(1):All Tissues
4:
[1]:
name:Adenine phosphoribosyltransferase deficiency (APRT)
smpdb_id:SMP00535
kegg_map_id:
[2]:
name:Adenosine Deaminase Deficiency
smpdb_id:SMP00144
kegg_map_id:
[3]:
name:Adenylosuccinate Lyase Deficiency
smpdb_id:SMP00167
kegg_map_id:
[4]:
name:AICA-Ribosiduria
smpdb_id:SMP00168
kegg_map_id:
[5]:
name:Azathioprine Action Pathway
smpdb_id:SMP00427
kegg_map_id:
[6]:
name:Gout or Kelley-Seegmiller Syndrome
smpdb_id:SMP00365
kegg_map_id:
[7]:
name:Lesch-Nyhan Syndrome (LNS)
smpdb_id:SMP00364
kegg_map_id:
[8]:
name:Mercaptopurine Action Pathway
smpdb_id:SMP00428
kegg_map_id:
[9]:
name:Mitochondrial DNA depletion syndrome
smpdb_id:SMP00536
kegg_map_id:
[10]:
name:Molybdenum Cofactor Deficiency
smpdb_id:SMP00203
kegg_map_id:
[11]:
name:Myoadenylate deaminase deficiency
smpdb_id:SMP00537
kegg_map_id:
[12]:
name:Purine metabolism
smpdb_id:
kegg_map_id:map00230
[13]:
name:Purine Nucleoside Phosphorylase Deficiency
smpdb_id:SMP00210
kegg_map_id:
[14]:
name:Thioguanine Action Pathway
smpdb_id:SMP00430
kegg_map_id:
[15]:
name:Xanthine Dehydrogenase Deficiency (Xanthinuria)
smpdb_id:SMP00220
kegg_map_id:
[16]:
name:Xanthinuria type I
smpdb_id:SMP00512
kegg_map_id:
[17]:
name:Xanthinuria type II
smpdb_id:SMP00513
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:0
concentration_units:uM
subject_age:Children (1 - 13 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
5:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
6:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
7:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
8:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
9:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
10:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
11:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
12:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
13:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
14:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
15:
biospecimen:Urine
concentration_value:1.00 (0.00-2.00)
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
16:
biospecimen:Urine
concentration_value:0-5
concentration_units:umol/mmol creatinine
subject_age:Children (1 - 18 years old)
subject_sex:Both
subject_condition:Normal
17:
biospecimen:Urine
concentration_value:<1.0
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
18:
biospecimen:Urine
concentration_value:<0.1
concentration_units:umol/mmol creatinine
subject_age:Infant (0-1 year old)
subject_sex:Both
subject_condition:Normal
异常浓度
1:
biospecimen:Blood
concentration_value:11.0 (2.0-20.0)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Purine nucleoside phosphorylase (PNP) deficiency
2:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
3:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
4:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
5:
biospecimen:Urine
concentration_value:177.0-322.0
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Not Specified
patient_information:Purine nucleoside phosphorylase (PNP) deficiency
疾病参考
1:
name:Colorectal cancer
omim_id:114500
[1]:
reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.
pubmed_id:7482520
[2]:
reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.
pubmed_id:19006102
[3]:
reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.
pubmed_id:23940645
[4]:
reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.
pubmed_id:24424155
[5]:
reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.
pubmed_id:20156336
[6]:
reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.
pubmed_id:19678709
[7]:
reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.
pubmed_id:22148915
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pubmed_id:25105552
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reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.
pubmed_id:21773981
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pubmed_id:25037050
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pubmed_id:27107423
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2:
name:Purine nucleoside phosphorylase deficiency
omim_id:164050
[1]:
reference_text:Chantin C, Bonin B, Boulieu R, Bory C: Liquid-chromatographic study of purine metabolism abnormalities in purine nucleoside phosphorylase deficiency. Clin Chem. 1996 Feb;42(2):326-8.
pubmed_id:8595732
[2]:
reference_text:Wevers RA, Engelke UF, Moolenaar SH, Brautigam C, de Jong JG, Duran R, de Abreu RA, van Gennip AH: 1H-NMR spectroscopy of body fluids: inborn errors of purine and pyrimidine metabolism. Clin Chem. 1999 Apr;45(4):539-48.
pubmed_id:10102915
[3]:
reference_text:Gandhi V, Kilpatrick JM, Plunkett W, Ayres M, Harman L, Du M, Bantia S, Davisson J, Wierda WG, Faderl S, Kantarjian H, Thomas D: A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine). Blood. 2005 Dec 15;106(13):4253-60. Epub 2005 Aug 30.
pubmed_id:16131572
代谢途径的数据库编号
DEOXYGUANOSINE
综合参考
Noguchi, Toshitada; Hamamoto, Tomoki; Okuyama, Kiyoshi; Shibuya, Susumu. Process for producing 2'-deoxyguanosine. PCT Int. Appl. (2003), 31 pp.
一般参考
1:
protein_accession:HMDBP00001
name:5'-nucleotidase
uniprot_id:P21589
gene_name:NT5E
protein_type:Unknown
2:
protein_accession:HMDBP00004
name:Cytosolic 5'-nucleotidase 1B
uniprot_id:Q96P26
gene_name:NT5C1B
protein_type:Unknown
3:
protein_accession:HMDBP00005
name:Cytosolic 5'-nucleotidase 1A
uniprot_id:Q9BXI3
gene_name:NT5C1A
protein_type:Unknown
4:
protein_accession:HMDBP00006
name:5'(3')-deoxyribonucleotidase, cytosolic type
uniprot_id:Q8TCD5
gene_name:NT5C
protein_type:Unknown
5:
protein_accession:HMDBP00008
name:5'(3')-deoxyribonucleotidase, mitochondrial
uniprot_id:Q9NPB1
gene_name:NT5M
protein_type:Unknown
6:
protein_accession:HMDBP00766
name:Deoxyguanosine kinase, mitochondrial
uniprot_id:Q16854
gene_name:DGUOK
protein_type:Enzyme
7:
protein_accession:HMDBP03189
name:Cytosolic 5'-nucleotidase 3
uniprot_id:Q9H0P0
gene_name:NT5C3
protein_type:Enzyme
8:
protein_accession:HMDBP03750
name:Cytosolic purine 5'-nucleotidase
uniprot_id:P49902
gene_name:NT5C2
protein_type:Unknown
9:
protein_accession:HMDBP03752
name:Purine nucleoside phosphorylase
uniprot_id:P00491
gene_name:PNP
protein_type:Enzyme
蛋白质结合
1:
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pubmed_id:16111881
2:
reference_text:Podmore K, Farmer PB, Herbert KE, Jones GD, Martin EA: 32P-postlabelling approaches for the detection of 8-oxo-2'-deoxyguanosine-3'-monophosphate in DNA. Mutat Res. 1997 Aug 1;378(1-2):139-49.
pubmed_id:9288892
3:
reference_text:Shibata T, Iio K, Kawai Y, Shibata N, Kawaguchi M, Toi S, Kobayashi M, Kobayashi M, Yamamoto K, Uchida K: Identification of a lipid peroxidation product as a potential trigger of the p53 pathway. J Biol Chem. 2006 Jan 13;281(2):1196-204. Epub 2005 Oct 26.
pubmed_id:16251187
4:
reference_text:Gackowski D, Ciecierski M, Jawien A, Olinski R: Background level of 8-oxo-2'-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma. Acta Biochim Pol. 2001;48(2):535-9.
pubmed_id:11732622
5:
reference_text:Takamura-Enya T, Watanabe M, Totsuka Y, Kanazawa T, Matsushima-Hibiya Y, Koyama K, Sugimura T, Wakabayashi K: Mono(ADP-ribosyl)ation of 2'-deoxyguanosine residue in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterfly. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12414-9. Epub 2001 Oct 9.
pubmed_id:11592983
6:
reference_text:Palozza P, Serini S, Di Nicuolo F, Boninsegna A, Torsello A, Maggiano N, Ranelletti FO, Wolf FI, Calviello G, Cittadini A: beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. Carcinogenesis. 2004 Aug;25(8):1315-25. Epub 2004 Apr 8.
pubmed_id:15073048
7:
reference_text:Zaidi SN, Laidlaw I, Howell A, Potten CS, Cooper DP, O'Connor PJ: Normal human breast xenografts activate N-nitrosodimethylamine: identification of potential target cells for an environmental nitrosamine. Br J Cancer. 1992 Jul;66(1):79-83.
pubmed_id:1637681
8:
reference_text:Gackowski D, Banaszkiewicz Z, Rozalski R, Jawien A, Olinski R: Persistent oxidative stress in colorectal carcinoma patients. Int J Cancer. 2002 Oct 1;101(4):395-7.
pubmed_id:12209966
9:
reference_text:Araki S, Hayashi M, Tamagawa K, Saito M, Kato S, Komori T, Sakakihara Y, Mizutani T, Oda M: Neuropathological analysis in spinal muscular atrophy type II. Acta Neuropathol. 2003 Nov;106(5):441-8. Epub 2003 Jul 25.
pubmed_id:12898156
10:
reference_text:Kato I, Ren J, Heilbrun LK, Djuric Z: Intra- and inter-individual variability in measurements of biomarkers for oxidative damage in vivo: Nutrition and Breast Health Study. Biomarkers. 2006 Mar-Apr;11(2):143-52.
pubmed_id:16766390
11:
reference_text:Izzedine H, Launay-Vacher V, Aymard G, Legrand M, Deray G: Pharmacokinetics of abacavir in HIV-1-infected patients with impaired renal function. Nephron. 2001 Sep;89(1):62-7.
pubmed_id:11528234
12:
reference_text:Wevers RA, Engelke UF, Moolenaar SH, Brautigam C, de Jong JG, Duran R, de Abreu RA, van Gennip AH: 1H-NMR spectroscopy of body fluids: inborn errors of purine and pyrimidine metabolism. Clin Chem. 1999 Apr;45(4):539-48.
pubmed_id:10102915
13:
reference_text:Bowen P, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, Kim HS, Christov-Tzelkov K, van Breemen R: Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med (Maywood). 2002 Nov;227(10):886-93.
pubmed_id:12424330
14:
reference_text:Staal GE, Stoop JW, Zegers BJ, Siegenbeek van Heukelom LH, van der Vlist MJ, Wadman SK, Martin DW: Erythrocyte metabolism in purine nucleoside phosphorylase deficiency after enzyme replacement therapy by infusion of erythrocytes. J Clin Invest. 1980 Jan;65(1):103-8.
pubmed_id:6765955
15:
reference_text:Blair IA: Lipid hydroperoxide-mediated DNA damage. Exp Gerontol. 2001 Sep;36(9):1473-81.
pubmed_id:11525870
16:
reference_text:Schramm VL: Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):107-17.
pubmed_id:12084452
17:
reference_text:Schilderman PA, Rhijnsburger E, Zwingmann I, Kleinjans JC: Induction of oxidative DNA damages and enhancement of cell proliferation in human lymphocytes in vitro by butylated hydroxyanisole. Carcinogenesis. 1995 Mar;16(3):507-12.
pubmed_id:7697806
18:
reference_text:Kaneko T, Tahara S: Formation of 8-oxo-2'-deoxyguanosine in the DNA of human diploid fibroblasts by treatment with linoleic acid hydroperoxide and ferric ion. Lipids. 2000 Sep;35(9):961-5.
pubmed_id:11026616
19:
reference_text:Hou SM, Nori P, Fang JL, Vaca CE: Methylglyoxal induces hprt mutation and DNA adducts in human T-lymphocytes in vitro. Environ Mol Mutagen. 1995;26(4):286-91.
pubmed_id:8575417
20:
reference_text:Bialkowski K, Kowara R, Windorbska W, Olinski R: 8-Oxo-2'-deoxyguanosine level in lymphocytes DNA of cancer patients undergoing radiotherapy. Cancer Lett. 1996 Jan 19;99(1):93-7.
pubmed_id:8564935
21:
reference_text:Markert ML: Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81.
pubmed_id:1931007