创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-07 19:37:13 UTC
描述
Dihydrouracil belongs to the class of organic compounds known as pyrimidones. Pyrimidones are compounds that contain a pyrimidine ring, which bears a ketone. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. Dihydrouracil is an intermediate breakdown product of uracil. Dihydrouracil exists in all living organisms, ranging from bacteria to plants to humans. Within humans, dihydrouracil participates in a number of enzymatic reactions. In particular, dihydrouracil can be biosynthesized from uracil; which is mediated by the enzyme dihydropyrimidine dehydrogenase [NADP(+)]. The breakdown of uracil is a multistep reaction that leads to the production of beta-alanine. The reaction process begins with the enzyme known as dihydropyrimidine dehydrogenase (DHP), which catalyzes the reduction of uracil into dihydrouracil. Then the enzyme known as dihydropyrimidinase hydrolyzes dihydrouracil into N-carbamyl-beta-alanine. Finally, beta-ureidopropionase catalyzes the conversion of N-carbamyl-beta-alanine into beta-alanine. There is at least one metabolic disorder that is associated with altered levels of dihydrouracil. In particular, dihydropyrimidinase deficiency is an inborn metabolic disorder that leads to highly increased concentrations of dihydrouracil and 5,6-dihydrothymine, and moderately increased concentrations of uracil and thymine in urine. Dihydropyrimidinase deficiency can cause neurological and gastrointestinal problems in some affected individuals (OMIM: 222748). In particular, patients with dihydropyrimidinase deficiency exhibit a number of neurological abnormalities including intellectual disability, seizures, weak muscle tone (hypotonia), an abnormally small head size (microcephaly), and autistic behaviours that affect communication and social interaction. Gastrointestinal problems that occur in dihydropyrimidinase deficiency include backflow of acidic stomach contents into the esophagus (gastroesophageal reflux) and recurrent episodes of vomiting.
同义词
1:2,4-Dioxotetrahydropyrimidine
2:5,6-Dihydro-2,4-dihydroxypyrimidine
3:Dihydro-2,4(1H,3H)-pyrimidinedione
4:DIHYDROPYRIMIDINE-2,4(1H,3H)-dione
5:Dihydrouracile
6:Hydrouracil
7:5,6-Dihydro-2,4(1H,3H)-pyrimidinedione
8:5,6-Dihydrouracil
9:Dihydro-pyrimidine-2,4-dione
化学名称
1,3-diazinane-2,4-dione
inchi标识符
InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8)
印记键
OIVLITBTBDPEFK-UHFFFAOYSA-N
分类学
description: belongs to the class of organic compounds known as pyrimidones. Pyrimidones are compounds that contain a pyrimidine ring, which bears a ketone. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
description:Pyrimidones
kingdom:Organic compounds
super_class:Organoheterocyclic compounds
class:Diazines
sub_class:Pyrimidines and pyrimidine derivatives
molecular_framework:Aliphatic heteromonocyclic compounds
1:Azacyclic compounds
2:Carbonyl compounds
3:Diazinanes
4:Dicarboximides
5:Hydrocarbon derivatives
6:N-acyl ureas
7:Organic oxides
8:Organonitrogen compounds
9:Organopnictogen compounds
10:1,3-diazinane
11:Aliphatic heteromonocyclic compound
12:Azacycle
13:Carbonic acid derivative
14:Carbonyl group
15:Carboxylic acid derivative
16:Dicarboximide
17:Hydrocarbon derivative
18:N-acyl urea
19:Organic nitrogen compound
20:Organic oxide
21:Organic oxygen compound
22:Organonitrogen compound
23:Organooxygen compound
24:Organopnictogen compound
25:Pyrimidone
26:Urea
27:Ureide
28:a base derivative
29:a pyrimidine-related compound
30:pyrimidone
本体论
term:Physiological effect
definition:The effect on an organism physiology, resulting from its exposure to a chemical.
parent_id:
level:1
type:parent
term:Health effect
definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.
parent_id:7693
*level:2
type:parent
term:Health condition
definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.
parent_id:7694
**level:3
type:parent
term:Vascular disorders
definition:Any disorder that affects the blood vessels.
parent_id:7695
***level:4
type:parent
term:Metabolism and nutrition disorders
definition:A group of disorders, inherited or not, that result in a metabolic malfunction.
parent_id:7695
***level:4
type:parent
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Animal
definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.
parent_id:7736
***level:4
type:child
synonym:Fauna
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Prostate
definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).
parent_id:7727
***level:4
type:child
synonym:Prostate gland
term:Liver
definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).
parent_id:7727
***level:4
type:child
term:Kidney
definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).
parent_id:7727
***level:4
type:child
synonym:Kidneys
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Cell
definition:
parent_id:7732
***level:4
type:parent
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Cerebrospinal fluid
definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).
parent_id:7731
***level:4
type:child
synonym:Csf
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Nucleus
definition:A body within the cell, surrounded by a membrane, within which lie the chromosomes, one or more nucleoli, combined with proteins, and exhibits mitosis. (NCI)
parent_id:7730
***level:4
type:child
synonym:Cell nucleus
synonym:Nucleic
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Biological role
definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.
parent_id:7671
*level:2
type:parent
term:Metabolite
definition:A chemical substance produced during metabolism process, as an intermediate or end-product.
parent_id:7672
**level:3
type:child
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
实验性质
1:
kind:melting_point
value:279 - 281 °C
source:
预测性质
1:
kind:logp
value:-1.28
source:ALOGPS
2:
kind:logs
value:-0.64
source:ALOGPS
3:
kind:solubility
value:25.9 g/L
source:ALOGPS
4:
kind:logp
value:-1.2
source:ChemAxon
5:
kind:pka_strongest_acidic
value:11.73
source:ChemAxon
6:
kind:pka_strongest_basic
value:-7.6
source:ChemAxon
7:
kind:iupac
value:1,3-diazinane-2,4-dione
source:ChemAxon
8:
kind:average_mass
value:114.1026
source:ChemAxon
9:
kind:mono_mass
value:114.042927446
source:ChemAxon
10:
kind:smiles
value:O=C1CCNC(=O)N1
source:ChemAxon
11:
kind:formula
value:C4H6N2O2
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8)
source:ChemAxon
13:
kind:inchikey
value:OIVLITBTBDPEFK-UHFFFAOYSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:58.2
source:ChemAxon
15:
kind:refractivity
value:25.75
source:ChemAxon
16:
kind:polarizability
value:10.13
source:ChemAxon
17:
kind:rotatable_bond_count
value:0
source:ChemAxon
18:
kind:acceptor_count
value:2
source:ChemAxon
19:
kind:donor_count
value:2
source:ChemAxon
20:
kind:physiological_charge
value:0
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:1
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::NmrTwoD
spectrum_id:1129
2:
type:Specdb::EiMs
spectrum_id:929
3:
type:Specdb::CMs
spectrum_id:315
4:
type:Specdb::CMs
spectrum_id:1151
5:
type:Specdb::CMs
spectrum_id:1251
6:
type:Specdb::CMs
spectrum_id:25806
7:
type:Specdb::CMs
spectrum_id:30862
8:
type:Specdb::CMs
spectrum_id:30984
9:
type:Specdb::CMs
spectrum_id:30985
10:
type:Specdb::CMs
spectrum_id:31803
11:
type:Specdb::CMs
spectrum_id:31805
12:
type:Specdb::CMs
spectrum_id:173971
13:
type:Specdb::MsMs
spectrum_id:123
14:
type:Specdb::MsMs
spectrum_id:124
15:
type:Specdb::MsMs
spectrum_id:125
16:
type:Specdb::MsMs
spectrum_id:2794
17:
type:Specdb::MsMs
spectrum_id:21041
18:
type:Specdb::MsMs
spectrum_id:21042
19:
type:Specdb::MsMs
spectrum_id:21043
20:
type:Specdb::MsMs
spectrum_id:22592
21:
type:Specdb::MsMs
spectrum_id:22593
22:
type:Specdb::MsMs
spectrum_id:22594
23:
type:Specdb::MsMs
spectrum_id:440047
24:
type:Specdb::MsMs
spectrum_id:448176
25:
type:Specdb::MsMs
spectrum_id:451880
26:
type:Specdb::MsMs
spectrum_id:2253489
27:
type:Specdb::MsMs
spectrum_id:2255092
28:
type:Specdb::MsMs
spectrum_id:2255472
29:
type:Specdb::MsMs
spectrum_id:2704826
30:
type:Specdb::MsMs
spectrum_id:2704827
31:
type:Specdb::MsMs
spectrum_id:2704828
32:
type:Specdb::MsMs
spectrum_id:3004146
33:
type:Specdb::MsMs
spectrum_id:3004147
34:
type:Specdb::MsMs
spectrum_id:3004148
35:
type:Specdb::NmrOneD
spectrum_id:1071
36:
type:Specdb::NmrOneD
spectrum_id:2411
37:
type:Specdb::NmrOneD
spectrum_id:3101
38:
type:Specdb::NmrOneD
spectrum_id:5592
39:
type:Specdb::NmrOneD
spectrum_id:5593
40:
type:Specdb::NmrOneD
spectrum_id:5594
41:
type:Specdb::NmrOneD
spectrum_id:5595
42:
type:Specdb::NmrOneD
spectrum_id:5596
43:
type:Specdb::NmrOneD
spectrum_id:5597
44:
type:Specdb::NmrOneD
spectrum_id:5598
45:
type:Specdb::NmrOneD
spectrum_id:5599
46:
type:Specdb::NmrOneD
spectrum_id:5600
47:
type:Specdb::NmrOneD
spectrum_id:5601
48:
type:Specdb::NmrOneD
spectrum_id:5602
49:
type:Specdb::NmrOneD
spectrum_id:5603
50:
type:Specdb::NmrOneD
spectrum_id:5604
51:
type:Specdb::NmrOneD
spectrum_id:5605
52:
type:Specdb::NmrOneD
spectrum_id:5606
53:
type:Specdb::NmrOneD
spectrum_id:5607
54:
type:Specdb::NmrOneD
spectrum_id:5608
55:
type:Specdb::NmrOneD
spectrum_id:5609
56:
type:Specdb::NmrOneD
spectrum_id:5610
57:
type:Specdb::NmrOneD
spectrum_id:5611
生物学性质
1:
cellular:(1):Cytoplasm
cellular:(2):Nucleus
2:
biospecimen:(1):Blood
biospecimen:(2):Cerebrospinal Fluid (CSF)
biospecimen:(3):Feces
biospecimen:(4):Saliva
biospecimen:(5):Urine
3:
tissue:(1):Fibroblasts
tissue:(2):Kidney
tissue:(3):Liver
tissue:(4):Prostate
4:
[1]:
name:Beta Ureidopropionase Deficiency
smpdb_id:SMP00172
kegg_map_id:
[2]:
name:beta-Alanine metabolism
smpdb_id:
kegg_map_id:map00410
[3]:
name:Carnosinuria, carnosinemia
smpdb_id:SMP00493
kegg_map_id:
[4]:
name:Dihydropyrimidinase Deficiency
smpdb_id:SMP00178
kegg_map_id:
[5]:
name:GABA-Transaminase Deficiency
smpdb_id:SMP00351
kegg_map_id:
[6]:
name:MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
smpdb_id:SMP00202
kegg_map_id:
[7]:
name:Pyrimidine metabolism
smpdb_id:
kegg_map_id:map00240
[8]:
name:UMP Synthase Deficiency (Orotic Aciduria)
smpdb_id:SMP00219
kegg_map_id:
[9]:
name:Ureidopropionase Deficiency
smpdb_id:SMP00492
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:0.31 (0.02-1.63)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
2:
biospecimen:Blood
concentration_value:0.31 (0.02-1.63)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Blood
concentration_value:0.32 ( 0.10-0.74)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
4:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:2.1 +/- 1.0
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
5:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
6:
biospecimen:Saliva
concentration_value:700 +/- 199
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
7:
biospecimen:Saliva
concentration_value:2168.16 +/- 127.94
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
8:
biospecimen:Saliva
concentration_value:2000 +/- 223
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
9:
biospecimen:Saliva
concentration_value:2000 +/- 223
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
10:
biospecimen:Saliva
concentration_value:2210 +/- 353
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
11:
biospecimen:Saliva
concentration_value:2240 +/- 380
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
12:
biospecimen:Saliva
concentration_value:2350 +/- 654
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
13:
biospecimen:Urine
concentration_value:0.79
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
14:
biospecimen:Urine
concentration_value:3.8 (2.1-8.3)
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
15:
biospecimen:Urine
concentration_value:2.4 +/- 4.7
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
16:
biospecimen:Urine
concentration_value:3.0 +/- 2.7
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
17:
biospecimen:Urine
concentration_value:2.5-20
concentration_units:umol/mmol creatinine
subject_age:Children (1 - 18 years old)
subject_sex:Both
subject_condition:Normal
18:
biospecimen:Urine
concentration_value:12.2 +/- 6.2
concentration_units:umol/mmol creatinine
subject_age:Infant (0-1 year old)
subject_sex:Both
subject_condition:Normal
19:
biospecimen:Urine
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
20:
biospecimen:Urine
concentration_value:<3.4
concentration_units:umol/mmol creatinine
subject_age:Infant (0-1 year old)
subject_sex:Both
subject_condition:Normal
异常浓度
1:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:81.5 (46.0-117.0)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Dihydropyrimidine dehydrogenase (DPD) deficiency
2:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
3:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
4:
biospecimen:Urine
concentration_value:2.4 +/- 1.67
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Hypertension
5:
biospecimen:Urine
concentration_value:627.0
concentration_units:umol/mmol creatinine
patient_age:Infant (0-1 year old)
patient_sex:Both
patient_information:Dihydropyrimidine dehydrogenase (DPD) deficiency
6:
biospecimen:Urine
concentration_value:2.4 +/- 2.00
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Cerebral infarction
7:
biospecimen:Urine
concentration_value:2.8 +/- 1.9
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Malignancy
8:
biospecimen:Urine
concentration_value:2.7 +/- 1.9
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Liver dysfunction
9:
biospecimen:Urine
concentration_value:2.5 +/- 2.00
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Nephropathy
疾病参考
1:
name:Colorectal cancer
omim_id:114500
[1]:
reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.
pubmed_id:7482520
[2]:
reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.
pubmed_id:19006102
[3]:
reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.
pubmed_id:23940645
[4]:
reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.
pubmed_id:24424155
[5]:
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2:
name:Dihydropyrimidine dehydrogenase deficiency
omim_id:274270
[1]:
reference_text:Van Kuilenburg AB, Stroomer AE, Van Lenthe H, Abeling NG, Van Gennip AH: New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid? Biochem J. 2004 Apr 1;379(Pt 1):119-24.
pubmed_id:14705962
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reference_text:Sumi S, Kidouchi K, Ohba S, Wada Y: Automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Oct 20;672(2):233-9.
pubmed_id:8581129
[3]:
reference_text:Brockstedt M, Jakobs C, Smit LM, van Gennip AH, Berger R: A new case of dihydropyrimidine dehydrogenase deficiency. J Inherit Metab Dis. 1990;13(1):121-4.
pubmed_id:2109146
[4]:
reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
pubmed_id:
3:
name:Hypertension
omim_id:145500
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pubmed_id:9816152
4:
name:Cerebral infarction
omim_id:
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reference_text:Hayashi K, Kidouchi K, Sumi S, Mizokami M, Orito E, Kumada K, Ueda R, Wada Y: Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria. Clin Cancer Res. 1996 Dec;2(12):1937-41.
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5:
name:Liver disease
omim_id:
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pubmed_id:9816152
综合参考
Bhat, K. S.; Rao, A. S. Synthesis of uracil, 6-methyluracil and some dihydrouracils. Organic Preparations and Procedures International (1983), 15(5), 303-13.
一般参考
1:
protein_accession:HMDBP00543
name:Dihydropyrimidinase
uniprot_id:Q14117
gene_name:DPYS
protein_type:Unknown
2:
protein_accession:HMDBP00727
name:Dihydropyrimidine dehydrogenase [NADP(+)]
uniprot_id:Q12882
gene_name:DPYD
protein_type:Unknown
蛋白质结合
1:
reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.
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2:
reference_text:Hofmann U, Schwab M, Seefried S, Marx C, Zanger UM, Eichelbaum M, Murdter TE: Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):371-80.
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3:
reference_text:Van Kuilenburg AB, Stroomer AE, Van Lenthe H, Abeling NG, Van Gennip AH: New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid? Biochem J. 2004 Apr 1;379(Pt 1):119-24.
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4:
reference_text:Grem JL: Intratumoral molecular or genetic markers as predictors of clinical outcome with chemotherapy in colorectal cancer. Semin Oncol. 2005 Feb;32(1):120-7.
pubmed_id:15726514
5:
reference_text:Assmann B, Hoffmann GF, Wagner L, Brautigam C, Seyberth HW, Duran M, Van Kuilenburg AB, Wevers R, Van Gennip AH: Dihydropyrimidinase deficiency and congenital microvillous atrophy: coincidence or genetic relation? J Inherit Metab Dis. 1997 Sep;20(5):681-8.
pubmed_id:9323563
6:
reference_text:Megyeri A, Bacso Z, Shields A, Eliason JF: Development of a stereological method to measure levels of fluoropyrimidine metabolizing enzymes in tumor sections using laser scanning cytometry. Cytometry A. 2005 Apr;64(2):62-71.
pubmed_id:15729713
7:
reference_text:Nakamura A, Kikuchi K, Ohishi T, Masuike T: [Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography]. Gan To Kagaku Ryoho. 2004 Mar;31(3):381-6.
pubmed_id:15045945
8:
reference_text:van Lenthe H, van Kuilenburg AB, Ito T, Bootsma AH, van Cruchten A, Wada Y, van Gennip AH: Defects in pyrimidine degradation identified by HPLC-electrospray tandem mass spectrometry of urine specimens or urine-soaked filter paper strips. Clin Chem. 2000 Dec;46(12):1916-22.
pubmed_id:11106323
9:
reference_text:Sumi S, Kidouchi K, Ohba S, Wada Y: Automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Oct 20;672(2):233-9.
pubmed_id:8581129
10:
reference_text:Shen GP, Galick H, Inoue M, Wallace SS: Decline of nuclear and mitochondrial oxidative base excision repair activity in late passage human diploid fibroblasts. DNA Repair (Amst). 2003 Jun 11;2(6):673-93.
pubmed_id:12767347
11:
reference_text:Tan BR, McLeod HL: Pharmacogenetic influences on treatment response and toxicity in colorectal cancer. Semin Oncol. 2005 Feb;32(1):113-9.
pubmed_id:15726513
12:
reference_text:Garcia AA, Blessing JA, Lenz HJ, Darcy KM, Mannel RS, Miller DS, Husseinzadeh N: Phase II clinical trial of capecitabine in ovarian carcinoma recurrent 6-12 months after completion of primary chemotherapy, with exploratory TS, DPD, and TP correlates: a Gynecologic Oncology Group study. Gynecol Oncol. 2005 Mar;96(3):810-7.
pubmed_id:15721430
13:
reference_text:Schneider S, Uchida K, Brabender J, Baldus SE, Yochim J, Danenberg KD, Salonga D, Chen P, Tsao-Wei D, Groshen S, Hoelscher AH, Schneider PM, Danenberg PV: Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer. J Am Coll Surg. 2005 Mar;200(3):336-44.
pubmed_id:15737843
14:
reference_text:Jiang H, Jiang J, Hu P, Hu Y: Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Mar 25;769(1):169-76.
pubmed_id:11936689