版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:45:10 UTC
登录号
HMDB0000068
地位
quantified
二级访问
HMDB0000615

HMDB00068

HMDB00615

名称
Epinephrine
描述
Epinephrine is a catecholamine, a sympathomimetic monoamine derived from the amino acids phenylalanine and tyrosine. It is the active sympathomimetic hormone secreted from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. Epinephrine also constricts arterioles in the skin and gut while dilating arterioles in leg muscles. It elevates the blood sugar level by increasing hydrolysis of glycogen to glucose in the liver, and at the same time begins the breakdown of lipids in adipocytes. Epinephrine has a suppressive effect on the immune system.
同义词
1:(-)-(R)-Epinephrine

2:(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

3:(-)-Adrenaline

4:(R)-(-)-Adrenaline

5:(R)-(-)-Adnephrine

6:(R)-(-)-Epinephrine

7:(R)-(-)-Epirenamine

8:4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

9:Adrenalin

10:Adrenaline

11:Epinefrina

12:Epinephrin

13:Epinephrinum

14:Epipen

15:Epipen JR

16:L-Adrenaline

17:Levoepinephrine

18:Primatene

19:Auvi-Q

20:(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

21:(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

22:(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

23:(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

24:(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

25:(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

26:(-)-Epinephrine

27:(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

28:(R)-Adrenaline

29:(R)-Epinephrine

30:Adnephrine

31:Adrenal

32:Adrenine

33:Adrin

34:Ana-kit

35:Bosmin

36:Bronkaid mist

37:Chelafrin

38:Epifrin

39:Epiglaufrin

40:Epinephran

41:Epirenan

42:Eppy

43:Exadrin

44:Glauposine

45:Hemisine

46:Hemostasin

47:Hemostatin

48:Hypernephrin

49:Isoptoepinal

50:L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

51:L-Epinephrine

52:L-Epirenamine

53:L-Methylaminoethanolcatechol

54:Levorenen

55:Levorenin

56:Levorenine

57:Levoreninum

58:Lyodrin

59:Methylarterenol

60:Mucidrina

61:Nephridine

62:Nieraline

63:Paranephrin

64:Primatene mist

65:R-(-)-Epinephrine

66:Renaglandin

67:Renaleptine

68:Renalina

69:Renoform

70:Renostypticin

71:Renostyptin

72:Scurenaline

73:Simplene

74:Styptirenal

75:Supracapsulin

76:Supranephrane

77:Suprarenaline

78:Suprarenin

79:Surrenine

80:Sus-phrine

81:Takamina

82:Vasoconstrictine

83:Vasotonin

84:4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

85:Epinephrine bitartrate

86:Epinephrine hydrogen tartrate

87:Lyophrin

88:Adrenaline bitartrate

89:Adrenaline hydrochloride

90:Epinephrine acetate

91:Allergan brand OF adrenaline hydrochloride

92:Epitrate

93:Acetate, epinephrine

94:Adrenaline acid tartrate

95:Epinephrine hydrochloride

96:Medihaler-epi

化学式
C9H13NO3
平均分子量
183.2044
等位分子量
183.089543287
化学名称
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
传统名称
epinephrine
CAS 登记号
51-43-4
代谢物结构字符串
CNC[C@H](O)C1=CC(O)=C(O)C=C1
inchi标识符
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
印记键
UCTWMZQNUQWSLP-VIFPVBQESA-N
分类学
description: belongs to the class of organic compounds known as catechols. Catechols are compounds containing a 1,2-benzenediol moiety.

description:Catechols

kingdom:Organic compounds

super_class:Benzenoids

class:Phenols

sub_class:Benzenediols

molecular_framework:Aromatic homomonocyclic compounds

1:1,2-aminoalcohols

2:1-hydroxy-2-unsubstituted benzenoids

3:1-hydroxy-4-unsubstituted benzenoids

4:Aralkylamines

5:Aromatic alcohols

6:Benzene and substituted derivatives

7:Dialkylamines

8:Hydrocarbon derivatives

9:Organopnictogen compounds

10:Secondary alcohols

11:1,2-aminoalcohol

12:1-hydroxy-2-unsubstituted benzenoid

13:1-hydroxy-4-unsubstituted benzenoid

14:Alcohol

15:Amine

16:Aralkylamine

17:Aromatic alcohol

18:Aromatic homomonocyclic compound

19:Catechol

20:Hydrocarbon derivative

21:Monocyclic benzene moiety

22:Organic nitrogen compound

23:Organic oxygen compound

24:Organonitrogen compound

25:Organooxygen compound

26:Organopnictogen compound

27:Secondary alcohol

28:Secondary aliphatic amine

29:Secondary amine

30:Adrenalines

31:Biogenic amines

32:adrenaline

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Pheochromocytoma

definition:

parent_id:7695

***level:4

type:child

synonym:Malignant phaeochromocytoma

synonym:Malignant pheochromocytoma

synonym:Phaeochromocytoma

term:Subarachnoid hemorrhage

definition:

parent_id:7695

***level:4

type:child

synonym:Sah

synonym:Subarachnoid haemorrhage

term:Schizophrenia

definition:A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (do).

parent_id:7695

***level:4

type:child

term:Addison's disease

definition:

parent_id:7695

***level:4

type:child

synonym:Hypocorticism

synonym:Hypocortisolism

synonym:Chronic adrenal insufficiency

term:Traumatic brain injury

definition:

parent_id:7695

***level:4

type:child

synonym:Head injury

synonym:Tbi

synonym:Intracranial injury

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Microbe

definition:A living organism that is of a microscopic scale, either single-celled or a cluster of cells.

parent_id:7736

***level:4

type:parent

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:Epidermis

definition:The epithelial portion of the skin (cutis). it consists of the following layers: stratum corneum (horny layer), stratum granulosum (granular layer), stratum spinosum (prickle cell layer), and stratum basale (basal cell layer). (nci).

parent_id:7729

***level:4

type:child

term:Adipose tissue

definition:A specialized form of connective tissue consisting primarily of adipocytes (fat cells), surrounded by a meshwork of collagen fibers. (NCI)

parent_id:7729

***level:4

type:child

synonym:Fat tissue

synonym:Body fat

synonym:Adipose

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Nervous tissue

definition:The tissue that generates and conducts electrical signals in the body. it contains the neurons. (nci).

parent_id:7729

***level:4

type:child

synonym:Neural tissue

synonym:Nerve tissue

term:Muscle

definition:A fibrous soft tissue with the ability to contract to produce force and motion. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Gonad

definition:A reproductive system organ that produces and releases either sperm (testis) or eggs (ovary). (nci).

parent_id:7727

***level:4

type:child

term:Intestine

definition:The portion of the gastrointestinal tract that includes the small and large intestines.

parent_id:7727

***level:4

type:child

term:Bladder

definition:The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra. (nci).

parent_id:7727

***level:4

type:child

term:Pancreas

definition:A digestive organ in the abdomen that has both endocrine and exocrine functions. (nci).

parent_id:7727

***level:4

type:child

term:Kidney

definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).

parent_id:7727

***level:4

type:child

synonym:Kidneys

term:Liver

definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).

parent_id:7727

***level:4

type:child

term:Endocrine gland

definition:

parent_id:7727

***level:4

type:parent

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Myelin sheath

definition:A layer of phospholipids and protein found on neuronal axons. this structure acts as an electrical insulator that allows nerve impulses to travel faster by increasing the resistance and decreasing the capacitance over that found in unmyelinated nerve fibers. (nci).

parent_id:7730

***level:4

type:child

synonym:Myelin

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Element

definition:

parent_id:7732

***level:4

type:parent

term:Cell

definition:

parent_id:7732

***level:4

type:parent

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

状态
Solid
实验性质
1:

kind:water_solubility

value:0.18 mg/mL

source:

2:

kind:logp

value:-1.37

source:HANSCH,C & LEO,AJ (1985)

3:

kind:melting_point

value:211.5 °C

source:

预测性质
1:

kind:logp

value:-0.82

source:ALOGPS

2:

kind:logs

value:-0.99

source:ALOGPS

3:

kind:solubility

value:18.6 g/L

source:ALOGPS

4:

kind:logp

value:-0.43

source:ChemAxon

5:

kind:pka_strongest_acidic

value:9.69

source:ChemAxon

6:

kind:pka_strongest_basic

value:8.91

source:ChemAxon

7:

kind:iupac

value:4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

source:ChemAxon

8:

kind:average_mass

value:183.2044

source:ChemAxon

9:

kind:mono_mass

value:183.089543287

source:ChemAxon

10:

kind:smiles

value:CNC[C@H](O)C1=CC(O)=C(O)C=C1

source:ChemAxon

11:

kind:formula

value:C9H13NO3

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1

source:ChemAxon

13:

kind:inchikey

value:UCTWMZQNUQWSLP-VIFPVBQESA-N

source:ChemAxon

14:

kind:polar_surface_area

value:72.72

source:ChemAxon

15:

kind:refractivity

value:49.23

source:ChemAxon

16:

kind:polarizability

value:19.04

source:ChemAxon

17:

kind:rotatable_bond_count

value:3

source:ChemAxon

18:

kind:acceptor_count

value:4

source:ChemAxon

19:

kind:donor_count

value:4

source:ChemAxon

20:

kind:physiological_charge

value:1

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:1

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::NmrTwoD

spectrum_id:1124

2:

type:Specdb::CMs

spectrum_id:308

3:

type:Specdb::CMs

spectrum_id:8108

4:

type:Specdb::CMs

spectrum_id:30537

5:

type:Specdb::CMs

spectrum_id:37278

6:

type:Specdb::CMs

spectrum_id:171963

7:

type:Specdb::NmrOneD

spectrum_id:1066

8:

type:Specdb::NmrOneD

spectrum_id:5532

9:

type:Specdb::NmrOneD

spectrum_id:5533

10:

type:Specdb::NmrOneD

spectrum_id:5534

11:

type:Specdb::NmrOneD

spectrum_id:5535

12:

type:Specdb::NmrOneD

spectrum_id:5536

13:

type:Specdb::NmrOneD

spectrum_id:5537

14:

type:Specdb::NmrOneD

spectrum_id:5538

15:

type:Specdb::NmrOneD

spectrum_id:5539

16:

type:Specdb::NmrOneD

spectrum_id:5540

17:

type:Specdb::NmrOneD

spectrum_id:5541

18:

type:Specdb::NmrOneD

spectrum_id:5542

19:

type:Specdb::NmrOneD

spectrum_id:5543

20:

type:Specdb::NmrOneD

spectrum_id:5544

21:

type:Specdb::NmrOneD

spectrum_id:5545

22:

type:Specdb::NmrOneD

spectrum_id:5546

23:

type:Specdb::NmrOneD

spectrum_id:5547

24:

type:Specdb::NmrOneD

spectrum_id:5548

25:

type:Specdb::NmrOneD

spectrum_id:5549

26:

type:Specdb::NmrOneD

spectrum_id:5550

27:

type:Specdb::NmrOneD

spectrum_id:5551

28:

type:Specdb::MsMs

spectrum_id:108

29:

type:Specdb::MsMs

spectrum_id:109

30:

type:Specdb::MsMs

spectrum_id:110

31:

type:Specdb::MsMs

spectrum_id:2739

32:

type:Specdb::MsMs

spectrum_id:2740

33:

type:Specdb::MsMs

spectrum_id:2741

34:

type:Specdb::MsMs

spectrum_id:2742

35:

type:Specdb::MsMs

spectrum_id:2743

36:

type:Specdb::MsMs

spectrum_id:2744

37:

type:Specdb::MsMs

spectrum_id:2745

38:

type:Specdb::MsMs

spectrum_id:2746

39:

type:Specdb::MsMs

spectrum_id:2747

40:

type:Specdb::MsMs

spectrum_id:2748

41:

type:Specdb::MsMs

spectrum_id:2749

42:

type:Specdb::MsMs

spectrum_id:2750

43:

type:Specdb::MsMs

spectrum_id:2751

44:

type:Specdb::MsMs

spectrum_id:2752

45:

type:Specdb::MsMs

spectrum_id:2753

46:

type:Specdb::MsMs

spectrum_id:257829

47:

type:Specdb::MsMs

spectrum_id:257830

48:

type:Specdb::MsMs

spectrum_id:257831

49:

type:Specdb::MsMs

spectrum_id:277767

50:

type:Specdb::MsMs

spectrum_id:277768

51:

type:Specdb::MsMs

spectrum_id:277769

52:

type:Specdb::MsMs

spectrum_id:436640

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Extracellular

2:

biospecimen:(1):Blood

biospecimen:(2):Cerebrospinal Fluid (CSF)

biospecimen:(3):Urine

3:

tissue:(1):Adipose Tissue

tissue:(2):Adrenal Cortex

tissue:(3):Adrenal Gland

tissue:(4):Adrenal Medulla

tissue:(5):Bladder

tissue:(6):Epidermis

tissue:(7):Eye Lens

tissue:(8):Fibroblasts

tissue:(9):Intestine

tissue:(10):Kidney

tissue:(11):Liver

tissue:(12):Neuron

tissue:(13):Ovary

tissue:(14):Pancreas

tissue:(15):Placenta

tissue:(16):Platelet

tissue:(17):Skeletal Muscle

tissue:(18):Testis

4:

[1]:

name:Alkaptonuria

smpdb_id:SMP00169

kegg_map_id:

[2]:

name:Aromatic L-Aminoacid Decarboxylase Deficiency

smpdb_id:SMP00170

kegg_map_id:

[3]:

name:Disulfiram Action Pathway

smpdb_id:SMP00429

kegg_map_id:

[4]:

name:Dopamine beta-hydroxylase deficiency

smpdb_id:SMP00498

kegg_map_id:

[5]:

name:Epinephrine Action Pathway

smpdb_id:SMP00661

kegg_map_id:

[6]:

name:Hawkinsinuria

smpdb_id:SMP00190

kegg_map_id:

[7]:

name:Monoamine oxidase-a deficiency (MAO-A)

smpdb_id:SMP00533

kegg_map_id:

[8]:

name:Tyrosine hydroxylase deficiency

smpdb_id:SMP00497

kegg_map_id:

[9]:

name:Tyrosine metabolism

smpdb_id:

kegg_map_id:map00350

[10]:

name:Tyrosine metabolism

smpdb_id:

kegg_map_id:map00350

[11]:

name:Tyrosinemia Type I

smpdb_id:SMP00218

kegg_map_id:

[12]:

name:Tyrosinemia, transient, of the newborn

smpdb_id:SMP00494

kegg_map_id:

正常浓度
1:

biospecimen:Blood

concentration_value:0.00164 +/- 0.00012

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:0.00029 +/- 0.000021

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:0.00072 (0.00049-0.0013)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:0.0003 +/- 0.00003

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

6:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0 (0.0-0.00022)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

7:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.000235 +/- 0.00003277

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

8:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.034 (0.0063-0.062)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

9:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.00024

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

10:

biospecimen:Urine

concentration_value:0.0057 +/- 0.00092

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

11:

biospecimen:Urine

concentration_value:0.002 +/- 0.00099

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

12:

biospecimen:Urine

concentration_value:0.0052 (0.00043-0.0099)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

13:

biospecimen:Urine

concentration_value:0.016 (0.001-0.089)

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

14:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

15:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

16:

biospecimen:Urine

concentration_value:0.0021 (0.00098-0.0052)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:0.00241 +/- 0.00057

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Head trauma

2:

biospecimen:Blood

concentration_value:0.000077 +/- 0.000025

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Addison's disease

3:

biospecimen:Blood

concentration_value:0.001 +/- 0.00036

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Subarachnoid haemorrhage

4:

biospecimen:Blood

concentration_value:0.00014 +/- 0.000036

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Addison's disease

5:

biospecimen:Blood

concentration_value:0.00029 (0.00005-0.00054)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Pheochromocytoma

6:

biospecimen:Blood

concentration_value:0.0025 (0.0002-0.0048)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Pheochromocytoma

7:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.000453 +/- 0.00004916

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:borderline hypertensives

8:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.000147 +/- 0.000109

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Cerebral infarction, headache, paresthesia and ununconfirmed suspicion of leucemic infaction or brain metastasis with normal CSF value

9:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.000109

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Cerebral infarction, headache, paresthesia and ununconfirmed suspicion of leucemic infaction or brain metastasis with normal CSF value but renal insufficiency

10:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.000251

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Haemorrhagic infarction

11:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.000300

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Bacterial meningitis

12:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.000481

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Leucemic meningiosa

13:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.000153

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Encephalitis

14:

biospecimen:Urine

concentration_value:0.011 +/- 0.0022

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Exercise

15:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

疾病参考
1:

name:Addison's Disease

omim_id:240200

[1]:

reference_text:Bornstein SR, Breidert M, Ehrhart-Bornstein M, Kloos B, Scherbaum WA: Plasma catecholamines in patients with Addison's disease. Clin Endocrinol (Oxf). 1995 Feb;42(2):215-8.

pubmed_id:7704967

[2]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

2:

name:Subarachnoid hemorrhage

omim_id:105800

[1]:

reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.

pubmed_id:15061359

[2]:

reference_text:Gaetani P, Rodriguez y Baena R, Vigano T, Crivellari MT: [Prostaglandin D2 in subarachnoid hemorrhage. Biological and diagnostic implications]. Riv Patol Nerv Ment. 1983 Jul-Aug;104(4):171-7.

pubmed_id:6598516

[3]:

reference_text:Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90.

pubmed_id:15993662

[4]:

reference_text:Lambert G, Naredi S, Eden E, Rydenhag B, Friberg P: Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus. Brain Res Bull. 2002 May;58(1):77-82.

pubmed_id:12121816

[5]:

reference_text:Durmaz R, Ozkara E, Kanbak G, Arslan OC, Dokumacioglu A, Kartkaya K, Atasoy MA: Nitric oxide level and adenosine deaminase activity in cerebrospinal fluid of patients with subarachnoid hemorrhage. Turk Neurosurg. 2008 Apr;18(2):157-64.

pubmed_id:18597230

3:

name:Pheochromocytoma

omim_id:171300

[1]:

reference_text:Eisenhofer G, Keiser H, Friberg P, Mezey E, Huynh TT, Hiremagalur B, Ellingson T, Duddempudi S, Eijsbouts A, Lenders JW: Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors. J Clin Endocrinol Metab. 1998 Jun;83(6):2175-85.

pubmed_id:9626157

[2]:

reference_text:Foti A, Adachi M, DeQuattro V: The relationships of free to conjugated normetanephrine in plasma and spinal fluid of hypertensive patients. J Clin Endocrinol Metab. 1982 Jul;55(1):81-5.

pubmed_id:7076810

4:

name:Head injury

omim_id:

[1]:

reference_text:Lambert G, Naredi S, Eden E, Rydenhag B, Friberg P: Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus. Brain Res Bull. 2002 May;58(1):77-82.

pubmed_id:12121816

[2]:

reference_text:Bogusiewicz A, Stratton SL, Ellison DA, Mock DM: Biotin accounts for less than half of all biotin and biotin metabolites in the cerebrospinal fluid of children. Am J Clin Nutr. 2008 Nov;88(5):1291-6.

pubmed_id:18996865

[3]:

reference_text:Sachse KT, Jackson EK, Wisniewski SR, Gillespie DG, Puccio AM, Clark RS, Dixon CE, Kochanek PM: Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans. J Cereb Blood Flow Metab. 2008 Feb;28(2):395-401. Epub 2007 Aug 8.

pubmed_id:17684518

[4]:

reference_text:Darwish RS, Amiridze N, Aarabi B: Nitrotyrosine as an oxidative stress marker: evidence for involvement in neurologic outcome in human traumatic brain injury. J Trauma. 2007 Aug;63(2):439-42.

pubmed_id:17693848

[5]:

reference_text:Bayir H, Kochanek PM, Liu SX, Arroyo A, Osipov A, Jiang J, Wisniewski S, Adelson PD, Graham SH, Kagan VE: Increased S-nitrosothiols and S-nitrosoalbumin in cerebrospinal fluid after severe traumatic brain injury in infants and children: indirect association with intracranial pressure. J Cereb Blood Flow Metab. 2003 Jan;23(1):51-61.

pubmed_id:12500091

[6]:

reference_text:Burke EJ, Mehlhorn U, Allen SJ: Hyaluronan in cerebrospinal fluid after head injury. Acta Neurol (Napoli). 1994 Jun;16(3):103-9.

pubmed_id:7992658

5:

name:Cerebral infarction

omim_id:

[1]:

reference_text:Hayashi K, Kidouchi K, Sumi S, Mizokami M, Orito E, Kumada K, Ueda R, Wada Y: Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria. Clin Cancer Res. 1996 Dec;2(12):1937-41.

pubmed_id:9816152

[2]:

reference_text:Fagan SC, Castellani D, Gengo FM: Prostanoid concentrations in human CSF following acute ischaemic brain infarction. Clin Exp Pharmacol Physiol. 1986 Aug;13(8):629-32.

pubmed_id:3791712

[3]:

reference_text:Ratge D, Bauersfeld W, Wisser H: The relationship of free and conjugated catecholamines in plasma and cerebrospinal fluid in cerebral and meningeal disease. J Neural Transm. 1985;62(3-4):267-84.

pubmed_id:4031843

6:

name:Bacterial meningitis

omim_id:

[1]:

reference_text:Peng F, Zhang B, Zhong X, Li J, Xu G, Hu X, Qiu W, Pei Z: Serum uric acid levels of patients with multiple sclerosis and other neurological diseases. Mult Scler. 2008 Mar;14(2):188-96. Epub 2007 Oct 17.

pubmed_id:17942520

[2]:

reference_text:Ratge D, Bauersfeld W, Wisser H: The relationship of free and conjugated catecholamines in plasma and cerebrospinal fluid in cerebral and meningeal disease. J Neural Transm. 1985;62(3-4):267-84.

pubmed_id:4031843

7:

name:Encephalitis

omim_id:

[1]:

reference_text:Kalita J, Kumar S, Vijaykumar K, Palit G, Misra UK: A study of CSF catecholamine and its metabolites in acute and convalescent period of encephalitis. J Neurol Sci. 2007 Jan 15;252(1):62-6. Epub 2006 Nov 28.

pubmed_id:17134724

[2]:

reference_text:Ratge D, Bauersfeld W, Wisser H: The relationship of free and conjugated catecholamines in plasma and cerebrospinal fluid in cerebral and meningeal disease. J Neural Transm. 1985;62(3-4):267-84.

pubmed_id:4031843

8:

name:Schizophrenia

omim_id:181500

[1]:

reference_text:Harnryd C, Bjerkenstedt L, Grimm VE, Sedvall G: Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment. Psychopharmacology (Berl). 1979 Aug 8;64(2):131-4.

pubmed_id:115032

[2]:

reference_text:Kobayashi K, Koide Y, Yoshino K, Shohmori T: [P-hydroxyphenylacetic acid concentrations in cerebrospinal fluid]. No To Shinkei. 1982 Aug;34(8):769-74.

pubmed_id:7126379

[3]:

reference_text:Alfredsson G, Wiesel FA: Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment. Psychopharmacology (Berl). 1989;99(3):322-7.

pubmed_id:2480613

[4]:

reference_text:Heresco-Levy U, Bar G, Levin R, Ermilov M, Ebstein RP, Javitt DC: High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients. Schizophr Res. 2007 Mar;91(1-3):14-21. Epub 2007 Feb 2.

pubmed_id:17276036

[5]:

reference_text:Walker EF, Bonsall R, Walder DJ: Plasma hormones and catecholamine metabolites in monozygotic twins discordant for psychosis. Neuropsychiatry Neuropsychol Behav Neurol. 2002 Mar;15(1):10-7.

pubmed_id:11877547

[6]:

reference_text:Hashimoto K, Fukushima T, Shimizu E, Komatsu N, Watanabe H, Shinoda N, Nakazato M, Kumakiri C, Okada S, Hasegawa H, Imai K, Iyo M: Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch Gen Psychiatry. 2003 Jun;60(6):572-6.

pubmed_id:12796220

[7]:

reference_text:Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuenod M, Holsboer F: gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. J Neurochem. 1995 Dec;65(6):2652-62.

pubmed_id:7595563

[8]:

reference_text:Nikisch G, Baumann P, Wiedemann G, Kiessling B, Weisser H, Hertel A, Yoshitake T, Kehr J, Mathe AA: Quetiapine and norquetiapine in plasma and cerebrospinal fluid of schizophrenic patients treated with quetiapine: correlations to clinical outcome and HVA, 5-HIAA, and MHPG in CSF. J Clin Psychopharmacol. 2010 Oct;30(5):496-503. doi: 10.1097/JCP.0b013e3181f2288e.

pubmed_id:20814316

[9]:

reference_text:Fukushima T, Iizuka H, Yokota A, Suzuki T, Ohno C, Kono Y, Nishikiori M, Seki A, Ichiba H, Watanabe Y, Hongo S, Utsunomiya M, Nakatani M, Sadamoto K, Yoshio T: Quantitative analyses of schizophrenia-associated metabolites in serum: serum D-lactate levels are negatively correlated with gamma-glutamylcysteine in medicated schizophrenia patients. PLoS One. 2014 Jul 8;9(7):e101652. doi: 10.1371/journal.pone.0101652. eCollection 2014.

pubmed_id:25004141

[10]:

reference_text:Koike S, Bundo M, Iwamoto K, Suga M, Kuwabara H, Ohashi Y, Shinoda K, Takano Y, Iwashiro N, Satomura Y, Nagai T, Natsubori T, Tada M, Yamasue H, Kasai K: A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study. Transl Psychiatry. 2014 Apr 8;4:e379. doi: 10.1038/tp.2014.19.

pubmed_id:24713860

[11]:

reference_text:Ballesteros A, Summerfelt A, Du X, Jiang P, Chiappelli J, Tagamets M, O'Donnell P, Kochunov P, Hong LE: Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia. Clin Neurophysiol. 2013 Nov;124(11):2209-15. doi: 10.1016/j.clinph.2013.05.021. Epub 2013 Jun 30.

pubmed_id:23823132

[12]:

reference_text:Bjerkenstedt L, Edman G, Hagenfeldt L, Sedvall G, Wiesel FA: Plasma amino acids in relation to cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy controls. Br J Psychiatry. 1985 Sep;147:276-82.

pubmed_id:2415198

[13]:

reference_text:Pickar D, Breier A, Hsiao JK, Doran AR, Wolkowitz OM, Pato CN, Konicki PE, Potter WZ: Cerebrospinal fluid and plasma monoamine metabolites and their relation to psychosis. Implications for regional brain dysfunction in schizophrenia. Arch Gen Psychiatry. 1990 Jul;47(7):641-8.

pubmed_id:1694425

[14]:

reference_text:Prell GD, Green JP, Kaufmann CA, Khandelwal JK, Morrishow AM, Kirch DG, Linnoila M, Wyatt RJ: Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and ratings of symptoms. Schizophr Res. 1995 Jan;14(2):93-104.

pubmed_id:7711000

[15]:

reference_text:Kim YK, Myint AM, Verkerk R, Scharpe S, Steinbusch H, Leonard B: Cytokine changes and tryptophan metabolites in medication-naive and medication-free schizophrenic patients. Neuropsychobiology. 2009;59(2):123-9. doi: 10.1159/000213565. Epub 2009 Apr 22.

pubmed_id:19390223

[16]:

reference_text:Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, Cao Y, Wang X, Qiu Y, Su M, Zhao A, Wang P, Yang P, Wu J, Feng G, He L, Jia W, Wan C: Potential metabolite markers of schizophrenia. Mol Psychiatry. 2013 Jan;18(1):67-78. doi: 10.1038/mp.2011.131. Epub 2011 Oct 25.

pubmed_id:22024767

[17]:

reference_text:Xuan J, Pan G, Qiu Y, Yang L, Su M, Liu Y, Chen J, Feng G, Fang Y, Jia W, Xing Q, He L: Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action. J Proteome Res. 2011 Dec 2;10(12):5433-43. doi: 10.1021/pr2006796. Epub 2011 Nov 8.

pubmed_id:22007635

[18]:

reference_text:Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S: Identification of a biological signature for schizophrenia in serum. Mol Psychiatry. 2012 May;17(5):494-502. doi: 10.1038/mp.2011.42. Epub 2011 Apr 12.

pubmed_id:21483431

[19]:

reference_text:Mathe AA, Eberhard G, Saaf J, Wetterberg L: Plasma prostaglandin E2 metabolite--measured as 11-deoxy-15-keto-13,14-dihydro-11 beta,16 xi-cyclo-PGE2--in twins with schizophrenic disorder. Biol Psychiatry. 1986 Sep;21(11):1024-30.

pubmed_id:3741918

[20]:

reference_text:Kuloglu M, Ustundag B, Atmaca M, Canatan H, Tezcan AE, Cinkilinc N: Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder. Cell Biochem Funct. 2002 Jun;20(2):171-5.

pubmed_id:11979513

[21]:

reference_text:Zumarraga M, Davila R, Basterreche N, Arrue A, Goienetxea B, Zamalloa MI, Erkoreka L, Bustamante S, Inchausti L, Gonzalez-Torres MA, Guimon J: Catechol O-methyltransferase and monoamine oxidase A genotypes, and plasma catecholamine metabolites in bipolar and schizophrenic patients. Neurochem Int. 2010 May-Jun;56(6-7):774-9. doi: 10.1016/j.neuint.2010.02.015. Epub 2010 Mar 4.

pubmed_id:20206656

[22]:

reference_text:Peters JG: Dopamine, noradrenaline and serotonin spinal fluid metabolites in temporal lobe epileptic patients with schizophrenic symptomatology. Eur Neurol. 1979;18(1):15-8.

pubmed_id:436860

[23]:

reference_text:Yao JK, Dougherty GG Jr, Reddy RD, Keshavan MS, Montrose DM, Matson WR, Rozen S, Krishnan RR, McEvoy J, Kaddurah-Daouk R: Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia. Mol Psychiatry. 2010 Sep;15(9):938-53. doi: 10.1038/mp.2009.33. Epub 2009 Apr 28.

pubmed_id:19401681

[24]:

reference_text:Gattaz WF, Waldmeier P, Beckmann H: CSF monoamine metabolites in schizophrenic patients. Acta Psychiatr Scand. 1982 Nov;66(5):350-60.

pubmed_id:6184954

[25]:

reference_text:Nilsson-Todd LK, Nordin C, Jonsson EG, Skogh E, Erhardt S: Cerebrospinal fluid kynurenic acid in male patients with schizophrenia - correlation with monoamine metabolites. Acta Neuropsychiatr. 2007 Feb;19(1):45-52. doi: 10.1111/j.1601-5215.2006.00170.x.

pubmed_id:26952797

[26]:

reference_text:Cai HL, Li HD, Yan XZ, Sun B, Zhang Q, Yan M, Zhang WY, Jiang P, Zhu RH, Liu YP, Fang PF, Xu P, Yuan HY, Zhang XH, Hu L, Yang W, Ye HS: Metabolomic analysis of biochemical changes in the plasma and urine of first-episode neuroleptic-naive schizophrenia patients after treatment with risperidone. J Proteome Res. 2012 Aug 3;11(8):4338-50. doi: 10.1021/pr300459d. Epub 2012 Jul 26.

pubmed_id:22800120

[27]:

reference_text:Al Awam K, Haussleiter IS, Dudley E, Donev R, Brune M, Juckel G, Thome J: Multiplatform metabolome and proteome profiling identifies serum metabolite and protein signatures as prospective biomarkers for schizophrenia. J Neural Transm (Vienna). 2015 Aug;122 Suppl 1:S111-22. doi: 10.1007/s00702-014-1224-0. Epub 2014 May 1.

pubmed_id:24789758

[28]:

reference_text:Bicikova M, Hill M, Ripova D, Mohr P, Hampl R: Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia. J Steroid Biochem Mol Biol. 2013 Jan;133:77-83. doi: 10.1016/j.jsbmb.2012.08.009. Epub 2012 Aug 24.

pubmed_id:22944140

[29]:

reference_text:He Y, Yu Z, Giegling I, Xie L, Hartmann AM, Prehn C, Adamski J, Kahn R, Li Y, Illig T, Wang-Sattler R, Rujescu D: Schizophrenia shows a unique metabolomics signature in plasma. Transl Psychiatry. 2012 Aug 14;2:e149. doi: 10.1038/tp.2012.76.

pubmed_id:22892715

[30]:

reference_text:Kaddurah-Daouk R, McEvoy J, Baillie RA, Lee D, Yao JK, Doraiswamy PM, Krishnan KR: Metabolomic mapping of atypical antipsychotic effects in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):934-45. Epub 2007 Apr 17.

pubmed_id:17440431

[31]:

reference_text:Fryar-Williams S, Strobel JE: Biomarkers of a five-domain translational substrate for schizophrenia and schizoaffective psychosis. Biomark Res. 2015 Feb 6;3:3. doi: 10.1186/s40364-015-0028-1. eCollection 2015.

pubmed_id:25729574

[32]:

reference_text:Oresic M, Seppanen-Laakso T, Sun D, Tang J, Therman S, Viehman R, Mustonen U, van Erp TG, Hyotylainen T, Thompson P, Toga AW, Huttunen MO, Suvisaari J, Kaprio J, Lonnqvist J, Cannon TD: Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia. Genome Med. 2012 Jan 18;4(1):1. doi: 10.1186/gm300.

pubmed_id:22257447

KEGG数据库编号
C00788
DrugBank数据库编号
DB00668
foodb数据库编号
FDB021889
ChemSpider数据库编号
5611
公共化学化合物编号
5816
PDB数据库编号
生物利益的化学实体数据库编号
28918
knapsack数据库编号
C00029643
维基百科编号
Epinephrine
代谢途径的数据库编号
L-EPINEPHRINE
苯酚资源管理器化合物数据库编号
比格数据库编号
35997
梅林编号
5127
虚拟机身份证编号
ADRNL
fbonto数据库编号
综合参考
Singer, Robert A.; Carreira, Erick M. An in situ procedure for catalytic, enantioselective acetate aldol addition. Application to the synthesis of (R)-(-)-epinephrine. Tetrahedron Letters (1997), 38(6), 927-930.
一般参考
1:

protein_accession:HMDBP00161

name:Amine oxidase [flavin-containing] B

uniprot_id:P27338

gene_name:MAOB

protein_type:Unknown

2:

protein_accession:HMDBP00169

name:Amine oxidase [flavin-containing] A

uniprot_id:P21397

gene_name:MAOA

protein_type:Unknown

3:

protein_accession:HMDBP00272

name:Catechol O-methyltransferase

uniprot_id:P21964

gene_name:COMT

protein_type:Unknown

4:

protein_accession:HMDBP00280

name:Phenylalanine-4-hydroxylase

uniprot_id:P00439

gene_name:PAH

protein_type:Enzyme

5:

protein_accession:HMDBP00406

name:Phenylethanolamine N-methyltransferase

uniprot_id:P11086

gene_name:PNMT

protein_type:Unknown

6:

protein_accession:HMDBP01601

name:Alpha-2A adrenergic receptor

uniprot_id:P08913

gene_name:ADRA2A

protein_type:Enzyme

7:

protein_accession:HMDBP01602

name:Alpha-2B adrenergic receptor

uniprot_id:P18089

gene_name:ADRA2B

protein_type:Enzyme

8:

protein_accession:HMDBP01632

name:Beta-1 adrenergic receptor

uniprot_id:P08588

gene_name:ADRB1

protein_type:Enzyme

9:

protein_accession:HMDBP01634

name:Beta-2 adrenergic receptor

uniprot_id:P07550

gene_name:ADRB2

protein_type:Enzyme

10:

protein_accession:HMDBP07433

name:Alpha-1A adrenergic receptor

uniprot_id:P35348

gene_name:ADRA1A

protein_type:Unknown

11:

protein_accession:HMDBP10805

name:Trace amine-associated receptor 1

uniprot_id:Q96RJ0

gene_name:TAAR1

protein_type:Unknown

蛋白质结合
1:

reference_text:Blagitko N, Schulz U, Schinzel AA, Ropers HH, Kalscheuer VM: gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. Hum Mol Genet. 1999 Dec;8(13):2387-96.

pubmed_id:10556286

2:

reference_text:Goldstein DS, Eisenhofer G, Kopin IJ: Sources and significance of plasma levels of catechols and their metabolites in humans. J Pharmacol Exp Ther. 2003 Jun;305(3):800-11. Epub 2003 Mar 20.

pubmed_id:12649306

3:

reference_text:Kurtis JD, Friedman JF, Leenstra T, Langdon GC, Wu HW, Manalo DL, Su L, Jiz M, Jarilla B, Pablo AO, McGarvey ST, Olveda RM, Acosta LP: Pubertal development predicts resistance to infection and reinfection with Schistosoma japonicum. Clin Infect Dis. 2006 Jun 15;42(12):1692-8. Epub 2006 May 12.

pubmed_id:16705573

4:

reference_text:Eisenhofer G, Keiser H, Friberg P, Mezey E, Huynh TT, Hiremagalur B, Ellingson T, Duddempudi S, Eijsbouts A, Lenders JW: Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors. J Clin Endocrinol Metab. 1998 Jun;83(6):2175-85.

pubmed_id:9626157

5:

reference_text:Igdoura SA, Gafuik C, Mertineit C, Saberi F, Pshezhetsky AV, Potier M, Trasler JM, Gravel RA: Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts. Hum Mol Genet. 1998 Jan;7(1):115-21.

pubmed_id:9384611

6:

reference_text:Kaufer D, Ogle WO, Pincus ZS, Clark KL, Nicholas AC, Dinkel KM, Dumas TC, Ferguson D, Lee AL, Winters MA, Sapolsky RM: Restructuring the neuronal stress response with anti-glucocorticoid gene delivery. Nat Neurosci. 2004 Sep;7(9):947-53. Epub 2004 Aug 8.

pubmed_id:15300253

7:

reference_text:Yasuda G, Umemura S, Ishii M: Characterization of bunazosin-sensitive alpha1-adrenoceptors in human renal medulla. J Cardiovasc Pharmacol. 1997 Aug;30(2):163-8.

pubmed_id:9269942

8:

reference_text:Gear AR, Camerini D: Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Microcirculation. 2003 Jun;10(3-4):335-50.

pubmed_id:12851650

9:

reference_text:Wilson BS, Petrella E, Lowe SR, Lien K, Mackensen DG, Gridley DS, Stickney DR: Radiolocalization of human small cell lung cancer and antigen-positive normal tissues using monoclonal antibody LS2D617. Cancer Res. 1990 May 15;50(10):3124-30.

pubmed_id:2159374

10:

reference_text:Blakely RD, Apparsundaram S: Structural diversity in the catecholamine transporter gene family: molecular cloning and characterization of an L-epinephrine transporter from bullfrog sympathetic ganglia. Adv Pharmacol. 1998;42:206-10.

pubmed_id:9327880

11:

reference_text:Belloni AS, Albertin G, Forneris ML, Nussdorfer GG: Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growth. Histol Histopathol. 2001 Oct;16(4):1263-74.

pubmed_id:11642745

12:

reference_text:Contreras LN, Arregger AL, Persi GG, Gonzalez NS, Cardoso EM: A new less-invasive and more informative low-dose ACTH test: salivary steroids in response to intramuscular corticotrophin. Clin Endocrinol (Oxf). 2004 Dec;61(6):675-82.

pubmed_id:15579180

13:

reference_text:Kushnir MM, Rockwood AL, Roberts WL, Pattison EG, Owen WE, Bunker AM, Meikle AW: Development and performance evaluation of a tandem mass spectrometry assay for 4 adrenal steroids. Clin Chem. 2006 Aug;52(8):1559-67. Epub 2006 Jun 15.

pubmed_id:16777916

14:

reference_text:Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K: Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase. Lancet. 1992 Mar 28;339(8796):770-3.

pubmed_id:1347802

15:

reference_text:Bornstein SR, Breidert M, Ehrhart-Bornstein M, Kloos B, Scherbaum WA: Plasma catecholamines in patients with Addison's disease. Clin Endocrinol (Oxf). 1995 Feb;42(2):215-8.

pubmed_id:7704967

16:

reference_text:Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50.

pubmed_id:12834252

17:

reference_text:Hiroi N, Yanagisawa R, Yoshida-Hiroi M, Endo T, Kawase T, Tsuchida Y, Toyama K, Shibuya K, Nakata K, Yoshino G: Retroperitoneal hemorrhage due to bilateral adrenal metastases from lung adenocarcinoma. J Endocrinol Invest. 2006 Jun;29(6):551-4.

pubmed_id:16840834

18:

reference_text:Kennedy B, Bigby TD, Ziegler MG: Nonadrenal epinephrine-forming enzymes in humans. Characteristics, distribution, regulation, and relationship to epinephrine levels. J Clin Invest. 1995 Jun;95(6):2896-902.

pubmed_id:7769131

19:

reference_text:Panholzer TJ, Beyer J, Lichtwald K: Coupled-column liquid chromatographic analysis of catecholamines, serotonin, and metabolites in human urine. Clin Chem. 1999 Feb;45(2):262-8.

pubmed_id:9931050

20:

reference_text:De Bellis MD, Baum AS, Birmaher B, Keshavan MS, Eccard CH, Boring AM, Jenkins FJ, Ryan ND: A.E. Bennett Research Award. Developmental traumatology. Part I: Biological stress systems. Biol Psychiatry. 1999 May 15;45(10):1259-70.

pubmed_id:10349032

21:

reference_text:Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Drager A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlic A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO: Recon3D enables a three-dimensional view of gene variation in human metabolism. Nat Biotechnol. 2018 Mar;36(3):272-281. doi: 10.1038/nbt.4072. Epub 2018 Feb 19.

pubmed_id:29457794

免责声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责,医药网对此不承担任何责任。
相关链接:国家药品监督管理局| 国家中医药管理局| SDA药品评审中心| 医加医疗器械| 膏药生产厂家| 爱视立眼贴
专业提供药品信息、药品招商、药品代理、保健品招商、医药原料采购供应的中国药品信息网站平台
版权所有 © 2003-2028 盗冒必究  客服热线:0575-83552251 / 13754370441  QQ客服:药品信息客服
浙ICP备16010490号-2 增值电信业务经营许可证:浙B2-20220931 互联网药品信息服务资格证书编号:(浙)-经营性2023-0215 浙公网安备:33068302000535
 医药代理商群1:药药网药品采购交流医药代理商群2:药药网药品采购交流2医药代理商群3:药药网药品采购交流3