创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:20:00 UTC
描述
Cyclic AMP (cAMP) or cyclic adenosine monophosphate is an adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. cAMP is found in all organisms ranging from bacteria to plants to animals. In humans and other mammals it is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon and ACTH. cAMP is synthesized from ATP by adenylate cyclase. Adenylate cyclase is located at the inner side of cell membranes. Adenylate cyclase is activated by the hormones glucagon and adrenaline and by G protein. Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline. cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. cAMP is primarily used for intracellular signal transduction, such as transferring into cells the effects of hormones like glucagon and adrenaline, which cannot pass through the plasma membrane. cAMP is also involved in the activation of protein kinases. In addition, cAMP binds to and regulates the function of ion channels such as the HCN channels. Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. HCN channels are sometimes referred to as pacemaker channels because they help to generate rhythmic activity within groups of heart and brain cells.
同义词
1:Adenosine 3',5'-cyclic monophosphate
2:Adenosine 3',5'-cyclic phosphate
3:Adenosine 3',5'-phosphate
4:ADENOSINE-3',5'-cyclic-monophosphATE
5:CAMP
6:Cyclic adenylic acid
7:Adenosine 3',5'-cyclic monophosphoric acid
8:Adenosine 3',5'-cyclic phosphoric acid
9:Adenosine 3',5'-phosphoric acid
10:ADENOSINE-3',5'-cyclic-monophosphoric acid
11:Cyclic adenylate
12:3'5'-Cyclic AMP
13:6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-D][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
14:Acrasin
15:Adenosine 3',5'-cyclophosphate
16:Adenosine 3',5'-monophosphate
17:Adenosine 3,5'-cyclic monophosphorate
18:Adenosine 3,5'-cyclic monophosphoric acid
19:Adenosine cyclic monophosphate
20:Adenosine cyclic-monophosphate
21:Adenosine-cyclic-phosphate
22:Adenosine-cyclic-phosphoric-acid
23:Cyclic 3',5'-adenylate
24:Cyclic 3',5'-adenylic acid
25:Cyclic 3',5'-AMP
26:Cyclic adenosine 3',5'-phosphate
27:3',5'-monoPhosphate, adenosine cyclic
28:Cyclic AMP, disodium salt
29:Cyclic AMP, monopotassium salt
30:Cyclic AMP, sodium salt
31:AMP, Cyclic
32:Adenosine cyclic 3',5' monophosphate
33:Adenosine cyclic-3',5'-monophosphate
34:Cyclic AMP, (R)-isomer
35:Cyclic AMP, monosodium salt
36:Adenosine cyclic 3',5'-monophosphate
37:monoPhosphate, adenosine cyclic
38:Adenosine cyclic 3,5 monophosphate
39:Cyclic 3',5'-monophosphate, adenosine
40:Cyclic AMP, monoammonium salt
41:Cyclic monophosphate, adenosine
42:Cyclic-3',5'-monophosphate, adenosine
43:Cyclic AMP
化学名称
(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
传统名称
(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2,7-dihydroxy-tetrahydro-4H-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
代谢物结构字符串
[H][C@@]12COP(O)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C=NC2=C1N=CN=C2N
inchi标识符
InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
印记键
IVOMOUWHDPKRLL-KQYNXXCUSA-N
分类学
description: belongs to the class of organic compounds known as 3',5'-cyclic purine nucleotides. These are purine nucleotides in which the oxygen atoms linked to the C3 and C5 carbon atoms of the ribose moiety are both bonded the same phosphorus atom of the phosphate group.
description:3',5'-cyclic purine nucleotides
kingdom:Organic compounds
super_class:Nucleosides, nucleotides, and analogues
class:Purine nucleotides
sub_class:Cyclic purine nucleotides
molecular_framework:Aromatic heteropolycyclic compounds
1:6-aminopurines
2:Aminopyrimidines and derivatives
3:Azacyclic compounds
4:Glycosylamines
5:Heteroaromatic compounds
6:Hydrocarbon derivatives
7:Imidolactams
8:Monosaccharide phosphates
9:N-substituted imidazoles
10:Organic oxides
11:Organic phosphoric acids and derivatives
12:Organopnictogen compounds
13:Oxacyclic compounds
14:Pentose phosphates
15:Primary amines
16:Secondary alcohols
17:Tetrahydrofurans
18:3',5'-cyclic purine ribonucleotide
19:6-aminopurine
20:Alcohol
21:Amine
22:Aminopyrimidine
23:Aromatic heteropolycyclic compound
24:Azacycle
25:Azole
26:Glycosyl compound
27:Heteroaromatic compound
28:Hydrocarbon derivative
29:Imidazole
30:Imidazopyrimidine
31:Imidolactam
32:Monosaccharide
33:Monosaccharide phosphate
34:N-glycosyl compound
35:N-substituted imidazole
36:Organic nitrogen compound
37:Organic oxide
38:Organic oxygen compound
39:Organic phosphoric acid derivative
40:Organoheterocyclic compound
41:Organonitrogen compound
42:Organooxygen compound
43:Organopnictogen compound
44:Oxacycle
45:Pentose phosphate
46:Primary amine
47:Purine
48:Pyrimidine
49:Secondary alcohol
50:Tetrahydrofuran
51:3',5'-Cyclic nuclcleotides
52:3',5'-cyclic purine nucleotide
53:adenyl ribonucleotide
本体论
term:Physiological effect
definition:The effect on an organism physiology, resulting from its exposure to a chemical.
parent_id:
level:1
type:parent
term:Health effect
definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.
parent_id:7693
*level:2
type:parent
term:Health condition
definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.
parent_id:7694
**level:3
type:parent
term:Chronic renal failure
definition:
parent_id:7695
***level:4
type:child
synonym:Ckf
synonym:Chronic kidney failure
synonym:End-stage renal disease
synonym:Esrd
synonym:Eskd
synonym:Stage 5 chronic kidney disease
synonym:Stage 5 ckd
synonym:Anephric patients
term:Hypoxic-ischemic encephalopathy
definition:
parent_id:7695
***level:4
type:child
synonym:Hie
term:Idiopathic polyneuritis
definition:
parent_id:7695
***level:4
type:child
synonym:Guillain-barre syndrome
synonym:Gbs
term:Nervous system disorders
definition:Any disorder (non-neoplastic or neoplastic) that affects the brain, spinal cord, or peripheral nerves.
parent_id:7695
***level:4
type:parent
term:Infections and infestations
definition:Any disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. it can be transmitted by direct or indirect contact. (nci).
parent_id:7695
***level:4
type:parent
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Animal
definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.
parent_id:7736
***level:4
type:child
synonym:Fauna
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:All tissues
definition:All tissues in the body of the organism.
parent_id:7729
***level:4
type:child
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Cerebrospinal fluid
definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).
parent_id:7731
***level:4
type:child
synonym:Csf
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Golgi
definition:A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. Note that the Golgi apparatus can be located in various places in the cytoplasm.
parent_id:7730
***level:4
type:child
synonym:Golgi apparatus
synonym:Golgi complex
synonym:Golgi ribbon
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
term:Biological role
definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.
parent_id:7671
*level:2
type:parent
term:Molecular messenger
definition: a chemical substance that is involved in transmission of biochemical signals.
parent_id:7672
**level:3
type:parent
term:Second messenger
definition:A chemical substance that transmit signals from a receptor to a target within a living cell.
parent_id:7677
***level:4
type:child
synonym:Secondary messenger
实验性质
1:
kind:water_solubility
value:4 mg/mL
source:
2:
kind:logp
value:-2.96
source:HANSCH,C ET AL. (1995)
3:
kind:melting_point
value:219 - 220 °C
source:
预测性质
1:
kind:logp
value:-2.29
source:ALOGPS
2:
kind:logs
value:-1.96
source:ALOGPS
3:
kind:solubility
value:3.58 g/L
source:ALOGPS
4:
kind:logp
value:-3.4
source:ChemAxon
5:
kind:pka_strongest_acidic
value:1.83
source:ChemAxon
6:
kind:pka_strongest_basic
value:3.92
source:ChemAxon
7:
kind:iupac
value:(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
source:ChemAxon
8:
kind:average_mass
value:329.2059
source:ChemAxon
9:
kind:mono_mass
value:329.052519653
source:ChemAxon
10:
kind:smiles
value:[H][C@@]12COP(O)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C=NC2=C1N=CN=C2N
source:ChemAxon
11:
kind:formula
value:C10H12N5O6P
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
source:ChemAxon
13:
kind:inchikey
value:IVOMOUWHDPKRLL-KQYNXXCUSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:154.84
source:ChemAxon
15:
kind:refractivity
value:70.29
source:ChemAxon
16:
kind:polarizability
value:28.42
source:ChemAxon
17:
kind:rotatable_bond_count
value:1
source:ChemAxon
18:
kind:acceptor_count
value:8
source:ChemAxon
19:
kind:donor_count
value:3
source:ChemAxon
20:
kind:physiological_charge
value:-1
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:4
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::CMs
spectrum_id:306
2:
type:Specdb::CMs
spectrum_id:2241
3:
type:Specdb::CMs
spectrum_id:25821
4:
type:Specdb::CMs
spectrum_id:30850
5:
type:Specdb::CMs
spectrum_id:30976
6:
type:Specdb::CMs
spectrum_id:37271
7:
type:Specdb::CMs
spectrum_id:168998
8:
type:Specdb::NmrOneD
spectrum_id:1059
9:
type:Specdb::NmrOneD
spectrum_id:4730
10:
type:Specdb::NmrOneD
spectrum_id:4731
11:
type:Specdb::NmrOneD
spectrum_id:141990
12:
type:Specdb::NmrOneD
spectrum_id:141991
13:
type:Specdb::NmrOneD
spectrum_id:141992
14:
type:Specdb::NmrOneD
spectrum_id:141993
15:
type:Specdb::NmrOneD
spectrum_id:141994
16:
type:Specdb::NmrOneD
spectrum_id:141995
17:
type:Specdb::NmrOneD
spectrum_id:141996
18:
type:Specdb::NmrOneD
spectrum_id:141997
19:
type:Specdb::NmrOneD
spectrum_id:141998
20:
type:Specdb::NmrOneD
spectrum_id:141999
21:
type:Specdb::NmrOneD
spectrum_id:142000
22:
type:Specdb::NmrOneD
spectrum_id:142001
23:
type:Specdb::NmrOneD
spectrum_id:142002
24:
type:Specdb::NmrOneD
spectrum_id:142003
25:
type:Specdb::NmrOneD
spectrum_id:142004
26:
type:Specdb::NmrOneD
spectrum_id:142005
27:
type:Specdb::NmrOneD
spectrum_id:142006
28:
type:Specdb::NmrOneD
spectrum_id:142007
29:
type:Specdb::NmrOneD
spectrum_id:142008
30:
type:Specdb::NmrOneD
spectrum_id:142009
31:
type:Specdb::NmrTwoD
spectrum_id:946
32:
type:Specdb::NmrTwoD
spectrum_id:1117
33:
type:Specdb::MsMs
spectrum_id:93
34:
type:Specdb::MsMs
spectrum_id:94
35:
type:Specdb::MsMs
spectrum_id:95
36:
type:Specdb::MsMs
spectrum_id:2693
37:
type:Specdb::MsMs
spectrum_id:2694
38:
type:Specdb::MsMs
spectrum_id:2695
39:
type:Specdb::MsMs
spectrum_id:2696
40:
type:Specdb::MsMs
spectrum_id:2697
41:
type:Specdb::MsMs
spectrum_id:2698
42:
type:Specdb::MsMs
spectrum_id:2699
43:
type:Specdb::MsMs
spectrum_id:2700
44:
type:Specdb::MsMs
spectrum_id:2701
45:
type:Specdb::MsMs
spectrum_id:2702
46:
type:Specdb::MsMs
spectrum_id:2703
47:
type:Specdb::MsMs
spectrum_id:2704
48:
type:Specdb::MsMs
spectrum_id:2705
49:
type:Specdb::MsMs
spectrum_id:2706
50:
type:Specdb::MsMs
spectrum_id:2707
51:
type:Specdb::MsMs
spectrum_id:2708
52:
type:Specdb::MsMs
spectrum_id:2710
53:
type:Specdb::MsMs
spectrum_id:2711
54:
type:Specdb::MsMs
spectrum_id:2712
55:
type:Specdb::MsMs
spectrum_id:179133
56:
type:Specdb::MsMs
spectrum_id:179134
57:
type:Specdb::MsMs
spectrum_id:179135
生物学性质
1:
cellular:(1):Cytoplasm
cellular:(2):Extracellular
cellular:(3):Golgi apparatus
2:
biospecimen:(1):Blood
biospecimen:(2):Cerebrospinal Fluid (CSF)
biospecimen:(3):Feces
biospecimen:(4):Urine
3:
tissue:(1):All Tissues
tissue:(2):Placenta
4:
[1]:
name:Adenine phosphoribosyltransferase deficiency (APRT)
smpdb_id:SMP00535
kegg_map_id:
[2]:
name:Adenosine Deaminase Deficiency
smpdb_id:SMP00144
kegg_map_id:
[3]:
name:Adenylosuccinate Lyase Deficiency
smpdb_id:SMP00167
kegg_map_id:
[4]:
name:AICA-Ribosiduria
smpdb_id:SMP00168
kegg_map_id:
[5]:
name:Azathioprine Action Pathway
smpdb_id:SMP00427
kegg_map_id:
[6]:
name:Corticotropin Activation of Cortisol Production
smpdb_id:SMP00310
kegg_map_id:
[7]:
name:Dopamine Activation of Neurological Reward System
smpdb_id:SMP00308
kegg_map_id:
[8]:
name:Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
smpdb_id:SMP00309
kegg_map_id:
[9]:
name:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
smpdb_id:SMP00312
kegg_map_id:
[10]:
name:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
smpdb_id:SMP00311
kegg_map_id:
[11]:
name:Gout or Kelley-Seegmiller Syndrome
smpdb_id:SMP00365
kegg_map_id:
[12]:
name:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb_id:SMP00320
kegg_map_id:
[13]:
name:Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdb_id:SMP00321
kegg_map_id:
[14]:
name:Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb_id:SMP00333
kegg_map_id:
[15]:
name:Intracellular Signalling Through Histamine H2 Receptor and Histamine
smpdb_id:SMP00335
kegg_map_id:
[16]:
name:Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdb_id:SMP00338
kegg_map_id:
[17]:
name:Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
smpdb_id:SMP00343
kegg_map_id:
[18]:
name:Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb_id:SMP00354
kegg_map_id:
[19]:
name:Lesch-Nyhan Syndrome (LNS)
smpdb_id:SMP00364
kegg_map_id:
[20]:
name:Lysophosphatidic Acid LPA1 Signalling
smpdb_id:SMP63746
kegg_map_id:
[21]:
name:Lysophosphatidic Acid LPA2 Signalling
smpdb_id:SMP63753
kegg_map_id:
[22]:
name:Lysophosphatidic Acid LPA3 Signalling
smpdb_id:SMP63755
kegg_map_id:
[23]:
name:Lysophosphatidic Acid LPA4 Signalling
smpdb_id:SMP63756
kegg_map_id:
[24]:
name:Lysophosphatidic Acid LPA5 Signalling
smpdb_id:SMP63757
kegg_map_id:
[25]:
name:Lysophosphatidic Acid LPA6 Signalling
smpdb_id:SMP63759
kegg_map_id:
[26]:
name:Mercaptopurine Action Pathway
smpdb_id:SMP00428
kegg_map_id:
[27]:
name:Mitochondrial DNA depletion syndrome
smpdb_id:SMP00536
kegg_map_id:
[28]:
name:Molybdenum Cofactor Deficiency
smpdb_id:SMP00203
kegg_map_id:
[29]:
name:Myoadenylate deaminase deficiency
smpdb_id:SMP00537
kegg_map_id:
[30]:
name:Purine metabolism
smpdb_id:
kegg_map_id:map00230
[31]:
name:Purine Nucleoside Phosphorylase Deficiency
smpdb_id:SMP00210
kegg_map_id:
[32]:
name:Thioguanine Action Pathway
smpdb_id:SMP00430
kegg_map_id:
[33]:
name:Vasopressin Regulation of Water Homeostasis
smpdb_id:SMP00322
kegg_map_id:
[34]:
name:Xanthine Dehydrogenase Deficiency (Xanthinuria)
smpdb_id:SMP00220
kegg_map_id:
[35]:
name:Xanthinuria type I
smpdb_id:SMP00512
kegg_map_id:
[36]:
name:Xanthinuria type II
smpdb_id:SMP00513
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:0.0085 +/- 0.0005
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.020 +/- 0.004
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.020+/- 0.004
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
4:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.024 (0.022-0.026)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
5:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.021 +/- 0.008
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
6:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.020 (0.016-0.024)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
7:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Children (6 - 18 years old)
subject_sex:Not Specified
subject_condition:Normal
8:
biospecimen:Urine
concentration_value:0.38 +/- 0.14
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
9:
biospecimen:Urine
concentration_value:0.22 +/- 0.055
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
异常浓度
1:
biospecimen:Blood
concentration_value:0.0077 +/- 0.0003
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Male
patient_information:Sildenafil-induced headache
2:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.0110 +/- 0.0028
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Idiopathic polyneuritis
3:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.033 +/- 0.012
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Not Specified
patient_information:Meningitis
4:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.00860 (0.00620-0.0110)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Hypoxic-ischemic encephalopathy
5:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.014 (0.012-0.017)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Hypoxic-ischemic encephalopathy
6:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.0202 +/- 0.004
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Not Specified
patient_information:Initial slight suspicion of meningitis with normal CSF
7:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.034 (0.021-0.046)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Meningitis
8:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.011 (0.0082-0.014)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Idiopathic polyneuritis
9:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Children (6 - 18 years old)
patient_sex:Not Specified
patient_information:Ulcerative colitis
10:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Children (6 - 18 years old)
patient_sex:Not Specified
patient_information:Unclassified IBD
11:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Children (6 - 18 years old)
patient_sex:Not Specified
patient_information:Crohns disease
12:
biospecimen:Urine
concentration_value:0.24 +/- 0.028
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Chronic renal failure
疾病参考
1:
name:Headache
omim_id:
[1]:
reference_text:Kruuse C, Frandsen E, Schifter S, Thomsen LL, Birk S, Olesen J: Plasma levels of cAMP, cGMP and CGRP in sildenafil-induced headache. Cephalalgia. 2004 Jul;24(7):547-53.
pubmed_id:15196297
2:
name:Idiopathic polyneuritis
omim_id:139393
[1]:
reference_text:Lerche A, Svenson M, Wiik A: Cerebrospinal fluid levels of cyclic nucleotides in meningitis and idiopathic polyneuritis. Acta Neurol Scand. 1984 Mar;69(3):168-75.
pubmed_id:6326460
3:
name:Hypoxic-ischemic encephalopathy
omim_id:
[1]:
reference_text:Liu H, Chang L, Chen Y, Xia S, Zhang X: Clinical implication of the changes of cAMP, TXA2 and PGI2 in CSF of asphyxiated newborns. J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):195-7, 200.
pubmed_id:12973949
[2]:
reference_text:Gucuyener K, Ergenekon E, Demiryurek T, Erbas D, Ozturk G, Koc E, Atalay Y: Cerebrospinal fluid levels of nitric oxide and nitrotyrosine in neonates with mild hypoxic-ischemic encephalopathy. J Child Neurol. 2002 Nov;17(11):815-8.
pubmed_id:12585720
4:
name:Meningitis
omim_id:
[1]:
reference_text:Rodriguez-Nunez A, Cid E, Rodriguez-Garcia J, Camina F, Rodriguez-Segade S, Castro-Gago M: Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis. Brain Dev. 2003 Mar;25(2):102-6.
pubmed_id:12581805
[2]:
reference_text:Subramanian A, Gupta A, Saxena S, Gupta A, Kumar R, Nigam A, Kumar R, Mandal SK, Roy R: Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children. NMR Biomed. 2005 Jun;18(4):213-25.
pubmed_id:15627241
[3]:
reference_text:Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51.
pubmed_id:7729054
[4]:
reference_text:Qureshi GA, Baig SM, Bednar I, Halawa A, Parvez SH: The neurochemical markers in cerebrospinal fluid to differentiate between aseptic and tuberculous meningitis. Neurochem Int. 1998 Feb;32(2):197-203.
pubmed_id:9542731
[5]:
reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.
pubmed_id:15061359
[6]:
reference_text:Kastenbauer S, Koedel U, Becker BF, Pfister HW: Oxidative stress in bacterial meningitis in humans. Neurology. 2002 Jan 22;58(2):186-91.
pubmed_id:11805243
[7]:
reference_text:Lerche A, Svenson M, Wiik A: Cerebrospinal fluid levels of cyclic nucleotides in meningitis and idiopathic polyneuritis. Acta Neurol Scand. 1984 Mar;69(3):168-75.
pubmed_id:6326460
[8]:
reference_text:Silva SO, Ximenes VF, Livramento JA, Catalani LH, Campa A: High concentrations of the melatonin metabolite, N1-acetyl-N2-formyl-5-methoxykynuramine, in cerebrospinal fluid of patients with meningitis: a possible immunomodulatory mechanism. J Pineal Res. 2005 Oct;39(3):302-6.
pubmed_id:16150112
[9]:
reference_text:Rating D, Siemes H, Loscher W: Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. J Neurol. 1983;230(4):217-25.
pubmed_id:6198481
[10]:
reference_text:Westcott JY, Murphy RC, Stenmark K: Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. Prostaglandins. 1987 Dec;34(6):877-87.
pubmed_id:2835791
[11]:
reference_text:Laurent UB, Laurent TC, Hellsing LK, Persson L, Hartman M, Lilja K: Hyaluronan in human cerebrospinal fluid. Acta Neurol Scand. 1996 Sep;94(3):194-206.
pubmed_id:8899053
5:
name:Crohn's disease
omim_id:266600
[1]:
reference_text:Lapidus A, Akerlund JE, Einarsson C: Gallbladder bile composition in patients with Crohn 's disease. World J Gastroenterol. 2006 Jan 7;12(1):70-4.
pubmed_id:16440420
[2]:
reference_text:Ehrenpreis ED, Salvino M, Craig RM: Improving the serum D-xylose test for the identification of patients with small intestinal malabsorption. J Clin Gastroenterol. 2001 Jul;33(1):36-40.
pubmed_id:11418788
[3]:
reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.
pubmed_id:8723414
[4]:
reference_text:Williams HR, Cox IJ, Walker DG, North BV, Patel VM, Marshall SE, Jewell DP, Ghosh S, Thomas HJ, Teare JP, Jakobovits S, Zeki S, Welsh KI, Taylor-Robinson SD, Orchard TR: Characterization of inflammatory bowel disease with urinary metabolic profiling. Am J Gastroenterol. 2009 Jun;104(6):1435-44. doi: 10.1038/ajg.2009.175. Epub 2009 Apr 28.
pubmed_id:19491857
[5]:
reference_text:Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y: Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb;6(2):546-51.
pubmed_id:17269711
[6]:
reference_text:Ahmed I, Greenwood R, Costello Bde L, Ratcliffe NM, Probert CS: An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PLoS One. 2013;8(3):e58204. doi: 10.1371/journal.pone.0058204. Epub 2013 Mar 13.
pubmed_id:23516449
[7]:
reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.
pubmed_id:23867873
[8]:
reference_text:De Preter V, Machiels K, Joossens M, Arijs I, Matthys C, Vermeire S, Rutgeerts P, Verbeke K: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015 Mar;64(3):447-58. doi: 10.1136/gutjnl-2013-306423. Epub 2014 May 8.
pubmed_id:24811995
[9]:
reference_text:Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, Gunther U, Nielsen OH: Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics. 2015;11:122-133. Epub 2014 Jun 1.
pubmed_id:25598765
[10]:
reference_text:Ahmed I, Greenwood R, Costello B, Ratcliffe N, Probert CS: Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Aliment Pharmacol Ther. 2016 Mar;43(5):596-611. doi: 10.1111/apt.13522. Epub 2016 Jan 25.
pubmed_id:26806034
[11]:
reference_text:Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.
pubmed_id:26848182
[12]:
reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.
pubmed_id:27609529
[13]:
reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.
pubmed_id:28842642
6:
name:Ulcerative colitis
omim_id:
[1]:
reference_text:Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. doi: 10.1093/nar/gkq1126. Epub 2010 Nov 8.
pubmed_id:21059682
[2]:
reference_text:Almer S, Andersson T, Strom M: Pharmacokinetics of tranexamic acid in patients with ulcerative colitis and in healthy volunteers after the single instillation of 2 g rectally. J Clin Pharmacol. 1992 Jan;32(1):49-54.
pubmed_id:1740537
[3]:
reference_text:Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y: Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb;6(2):546-51.
pubmed_id:17269711
[4]:
reference_text:Garner CE, Smith S, de Lacy Costello B, White P, Spencer R, Probert CS, Ratcliffe NM: Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB J. 2007 Jun;21(8):1675-88. Epub 2007 Feb 21.
pubmed_id:17314143
[5]:
reference_text:Le Gall G, Noor SO, Ridgway K, Scovell L, Jamieson C, Johnson IT, Colquhoun IJ, Kemsley EK, Narbad A: Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J Proteome Res. 2011 Sep 2;10(9):4208-18. doi: 10.1021/pr2003598. Epub 2011 Aug 8.
pubmed_id:21761941
[6]:
reference_text:Ahmed I, Greenwood R, Costello Bde L, Ratcliffe NM, Probert CS: An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PLoS One. 2013;8(3):e58204. doi: 10.1371/journal.pone.0058204. Epub 2013 Mar 13.
pubmed_id:23516449
[7]:
reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.
pubmed_id:23867873
[8]:
reference_text:De Preter V, Machiels K, Joossens M, Arijs I, Matthys C, Vermeire S, Rutgeerts P, Verbeke K: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015 Mar;64(3):447-58. doi: 10.1136/gutjnl-2013-306423. Epub 2014 May 8.
pubmed_id:24811995
[9]:
reference_text:Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, Gunther U, Nielsen OH: Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics. 2015;11:122-133. Epub 2014 Jun 1.
pubmed_id:25598765
[10]:
reference_text:Ahmed I, Greenwood R, Costello B, Ratcliffe N, Probert CS: Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Aliment Pharmacol Ther. 2016 Mar;43(5):596-611. doi: 10.1111/apt.13522. Epub 2016 Jan 25.
pubmed_id:26806034
[11]:
reference_text:Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.
pubmed_id:26848182
[12]:
reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.
pubmed_id:27609529
[13]:
reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.
pubmed_id:28842642
7:
name:Chronic renal failure
omim_id:
[1]:
reference_text:Hegedus ZL, Frank HA, Steinman TI, Altschule MD, Nayak U: Elevated levels of plasma lipofuscins in patients with chronic renal failure. Arch Int Physiol Biochim. 1988 Dec;96(5):211-21.
pubmed_id:2474282
[2]:
reference_text:McGregor DO, Dellow WJ, Lever M, George PM, Robson RA, Chambers ST: Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. Kidney Int. 2001 Jun;59(6):2267-72.
pubmed_id:11380830
[3]:
reference_text:Dimitrakov D, Kumchev E, Lyutakova E, Ledzhev I, Nikolov D, Tsekov V: Cyclic adenosine monophosphate (cAMP) levels in predialysis patients with chronic renal failure. Folia Med (Plovdiv). 1997;39(1):29-33.
pubmed_id:9141788
[4]:
reference_text:Kikuchi T, Orita Y, Ando A, Mikami H, Fujii M, Okada A, Abe H: Liquid-chromatographic determination of guanidino compounds in plasma and erythrocyte of normal persons and uremic patients. Clin Chem. 1981 Nov;27(11):1899-902.
pubmed_id:7296840
[5]:
reference_text:Kand'ar R, Zakova P: Allantoin as a marker of oxidative stress in human erythrocytes. Clin Chem Lab Med. 2008;46(9):1270-4. doi: 10.1515/CCLM.2008.244.
pubmed_id:18636793
综合参考
Genieser, H. G.; Butt, E.; Bottin, U.; Dostmann, W.; Jastorff, B. Synthesis of the 3',5'-cyclic phosphates from unprotected nucleosides. Synthesis (1989), (1), 53-4.
一般参考
1:
protein_accession:HMDBP00011
name:Histone acetyltransferase p300
uniprot_id:Q09472
gene_name:EP300
protein_type:Unknown
2:
protein_accession:HMDBP00014
name:CREB-binding protein
uniprot_id:Q92793
gene_name:CREBBP
protein_type:Unknown
3:
protein_accession:HMDBP00119
name:Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
uniprot_id:P22413
gene_name:ENPP1
protein_type:Unknown
4:
protein_accession:HMDBP00531
name:Hormone-sensitive lipase
uniprot_id:Q05469
gene_name:LIPE
protein_type:Unknown
5:
protein_accession:HMDBP00561
name:Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
uniprot_id:Q13956
gene_name:PDE6H
protein_type:Enzyme
6:
protein_accession:HMDBP00571
name:Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
uniprot_id:P54750
gene_name:PDE1A
protein_type:Unknown
7:
protein_accession:HMDBP00575
name:High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
uniprot_id:O60658
gene_name:PDE8A
protein_type:Unknown
8:
protein_accession:HMDBP00576
name:Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
uniprot_id:Q01064
gene_name:PDE1B
protein_type:Enzyme
9:
protein_accession:HMDBP00578
name:cGMP-inhibited 3',5'-cyclic phosphodiesterase B
uniprot_id:Q13370
gene_name:PDE3B
protein_type:Enzyme
10:
protein_accession:HMDBP00590
name:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
uniprot_id:Q13946
gene_name:PDE7A
protein_type:Unknown
11:
protein_accession:HMDBP00600
name:cGMP-inhibited 3',5'-cyclic phosphodiesterase A
uniprot_id:Q14432
gene_name:PDE3A
protein_type:Unknown
12:
protein_accession:HMDBP00604
name:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
uniprot_id:Q9Y233
gene_name:PDE10A
protein_type:Unknown
13:
protein_accession:HMDBP00605
name:Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
uniprot_id:Q14123
gene_name:PDE1C
protein_type:Unknown
14:
protein_accession:HMDBP00609
name:cAMP-specific 3',5'-cyclic phosphodiesterase 4B
uniprot_id:Q07343
gene_name:PDE4B
protein_type:Unknown
15:
protein_accession:HMDBP00612
name:cAMP-specific 3',5'-cyclic phosphodiesterase 7B
uniprot_id:Q9NP56
gene_name:PDE7B
protein_type:Unknown
16:
protein_accession:HMDBP00616
name:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
uniprot_id:O76083
gene_name:PDE9A
protein_type:Unknown
17:
protein_accession:HMDBP00617
name:cGMP-dependent 3',5'-cyclic phosphodiesterase
uniprot_id:O00408
gene_name:PDE2A
protein_type:Unknown
18:
protein_accession:HMDBP00630
name:High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
uniprot_id:O95263
gene_name:PDE8B
protein_type:Unknown
19:
protein_accession:HMDBP00631
name:cAMP-specific 3',5'-cyclic phosphodiesterase 4C
uniprot_id:Q08493
gene_name:PDE4C
protein_type:Unknown
20:
protein_accession:HMDBP00636
name:cAMP-specific 3',5'-cyclic phosphodiesterase 4D
uniprot_id:Q08499
gene_name:PDE4D
protein_type:Unknown
21:
protein_accession:HMDBP00637
name:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
uniprot_id:P18545
gene_name:PDE6G
protein_type:Enzyme
22:
protein_accession:HMDBP00641
name:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
uniprot_id:O43924
gene_name:PDE6D
protein_type:Enzyme
23:
protein_accession:HMDBP00650
name:cAMP-specific 3',5'-cyclic phosphodiesterase 4A
uniprot_id:P27815
gene_name:PDE4A
protein_type:Unknown
24:
protein_accession:HMDBP00655
name:cGMP-specific 3',5'-cyclic phosphodiesterase
uniprot_id:O76074
gene_name:PDE5A
protein_type:Unknown
25:
protein_accession:HMDBP00704
name:Adenylate cyclase type 7
uniprot_id:P51828
gene_name:ADCY7
protein_type:Unknown
26:
protein_accession:HMDBP00705
name:Adenylate cyclase type 4
uniprot_id:Q8NFM4
gene_name:ADCY4
protein_type:Unknown
27:
protein_accession:HMDBP00706
name:Adenylate cyclase type 6
uniprot_id:O43306
gene_name:ADCY6
protein_type:Unknown
28:
protein_accession:HMDBP00707
name:Adenylate cyclase type 5
uniprot_id:O95622
gene_name:ADCY5
protein_type:Unknown
29:
protein_accession:HMDBP00708
name:Adenylate cyclase type 8
uniprot_id:P40145
gene_name:ADCY8
protein_type:Unknown
30:
protein_accession:HMDBP00709
name:Adenylate cyclase type 9
uniprot_id:O60503
gene_name:ADCY9
protein_type:Unknown
31:
protein_accession:HMDBP00710
name:Adenylate cyclase type 3
uniprot_id:O60266
gene_name:ADCY3
protein_type:Unknown
32:
protein_accession:HMDBP00711
name:Adenylate cyclase type 1
uniprot_id:Q08828
gene_name:ADCY1
protein_type:Unknown
33:
protein_accession:HMDBP00921
name:Adenylate cyclase type 2
uniprot_id:Q08462
gene_name:ADCY2
protein_type:Unknown
34:
protein_accession:HMDBP01043
name:Steroid 17-alpha-hydroxylase/17,20 lyase
uniprot_id:P05093
gene_name:CYP17A1
protein_type:Unknown
35:
protein_accession:HMDBP01119
name:Cyclic nucleotide-gated cation channel alpha-3
uniprot_id:Q16281
gene_name:CNGA3
protein_type:Unknown
36:
protein_accession:HMDBP01122
name:Cyclic nucleotide-gated cation channel beta-3
uniprot_id:Q9NQW8
gene_name:CNGB3
protein_type:Unknown
37:
protein_accession:HMDBP01123
name:Rap guanine nucleotide exchange factor 2
uniprot_id:Q9Y4G8
gene_name:RAPGEF2
protein_type:Unknown
38:
protein_accession:HMDBP01126
name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
uniprot_id:O60741
gene_name:HCN1
protein_type:Unknown
39:
protein_accession:HMDBP01207
name:cAMP-dependent protein kinase catalytic subunit gamma
uniprot_id:P22612
gene_name:PRKACG
protein_type:Unknown
40:
protein_accession:HMDBP01352
name:cAMP-dependent protein kinase catalytic subunit alpha
uniprot_id:P17612
gene_name:PRKACA
protein_type:Unknown
41:
protein_accession:HMDBP01399
name:Serine/threonine-protein kinase PRKY
uniprot_id:O43930
gene_name:PRKY
protein_type:Unknown
42:
protein_accession:HMDBP01415
name:cAMP-dependent protein kinase catalytic subunit beta
uniprot_id:P22694
gene_name:PRKACB
protein_type:Unknown
43:
protein_accession:HMDBP01491
name:Ribosomal protein S6 kinase alpha-5
uniprot_id:O75582
gene_name:RPS6KA5
protein_type:Unknown
44:
protein_accession:HMDBP01498
name:Serine/threonine-protein kinase PRKX
uniprot_id:P51817
gene_name:PRKX
protein_type:Unknown
45:
protein_accession:HMDBP01530
name:Serine/threonine-protein kinase 11
uniprot_id:Q15831
gene_name:STK11
protein_type:Unknown
46:
protein_accession:HMDBP01618
name:ATP-binding cassette sub-family A member 1
uniprot_id:O95477
gene_name:ABCA1
protein_type:Unknown
47:
protein_accession:HMDBP01793
name:Na(+)/H(+) exchange regulatory cofactor NHE-RF1
uniprot_id:O14745
gene_name:SLC9A3R1
protein_type:Unknown
48:
protein_accession:HMDBP01861
name:Aryl hydrocarbon receptor
uniprot_id:P35869
gene_name:AHR
protein_type:Unknown
49:
protein_accession:HMDBP01865
name:Cyclic AMP-responsive element-binding protein 5
uniprot_id:Q02930
gene_name:CREB5
protein_type:Unknown
50:
protein_accession:HMDBP01925
name:Class E basic helix-loop-helix protein 40
uniprot_id:O14503
gene_name:BHLHE40
protein_type:Unknown
51:
protein_accession:HMDBP01953
name:Splicing factor, proline- and glutamine-rich
uniprot_id:P23246
gene_name:SFPQ
protein_type:Unknown
52:
protein_accession:HMDBP01963
name:Ras-related protein Rap-1A
uniprot_id:P62834
gene_name:RAP1A
protein_type:Unknown
53:
protein_accession:HMDBP02095
name:Calcitonin gene-related peptide 1
uniprot_id:P06881
gene_name:CALCA
protein_type:Unknown
54:
protein_accession:HMDBP02133
name:Cyclic AMP-responsive element-binding protein 1
uniprot_id:P16220
gene_name:CREB1
protein_type:Unknown
55:
protein_accession:HMDBP02134
name:Thyrotropin receptor
uniprot_id:P16473
gene_name:TSHR
protein_type:Unknown
56:
protein_accession:HMDBP02176
name:Glial cell line-derived neurotrophic factor
uniprot_id:P39905
gene_name:GDNF
protein_type:Unknown
57:
protein_accession:HMDBP02212
name:Potassium voltage-gated channel subfamily H member 2
uniprot_id:Q12809
gene_name:KCNH2
protein_type:Unknown
58:
protein_accession:HMDBP02245
name:Potassium voltage-gated channel subfamily H member 6
uniprot_id:Q9H252
gene_name:KCNH6
protein_type:Unknown
59:
protein_accession:HMDBP02250
name:Methyl-CpG-binding domain protein 2
uniprot_id:Q9UBB5
gene_name:MBD2
protein_type:Unknown
60:
protein_accession:HMDBP02401
name:Relaxin receptor 1
uniprot_id:Q9HBX9
gene_name:RXFP1
protein_type:Unknown
61:
protein_accession:HMDBP02421
name:cAMP-responsive element modulator
uniprot_id:Q03060
gene_name:CREM
protein_type:Unknown
62:
protein_accession:HMDBP02512
name:Adiponectin
uniprot_id:Q15848
gene_name:ADIPOQ
protein_type:Unknown
63:
protein_accession:HMDBP02560
name:cAMP-dependent protein kinase type I-alpha regulatory subunit
uniprot_id:P10644
gene_name:PRKAR1A
protein_type:Unknown
64:
protein_accession:HMDBP02618
name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
uniprot_id:Q9UL51
gene_name:HCN2
protein_type:Unknown
65:
protein_accession:HMDBP02623
name:Cortistatin
uniprot_id:O00230
gene_name:CORT
protein_type:Unknown
66:
protein_accession:HMDBP02663
name:Perilipin-1
uniprot_id:O60240
gene_name:PLIN1
protein_type:Unknown
67:
protein_accession:HMDBP02759
name:Prostaglandin D2 receptor
uniprot_id:Q13258
gene_name:PTGDR
protein_type:Unknown
68:
protein_accession:HMDBP02762
name:Rap guanine nucleotide exchange factor 3
uniprot_id:O95398
gene_name:RAPGEF3
protein_type:Unknown
69:
protein_accession:HMDBP02768
name:Platelet basic protein
uniprot_id:P02775
gene_name:PPBP
protein_type:Unknown
70:
protein_accession:HMDBP02824
name:Vasodilator-stimulated phosphoprotein
uniprot_id:P50552
gene_name:VASP
protein_type:Unknown
71:
protein_accession:HMDBP02849
name:Inositol 1,4,5-trisphosphate receptor type 1
uniprot_id:Q14643
gene_name:ITPR1
protein_type:Unknown
72:
protein_accession:HMDBP02943
name:Rap guanine nucleotide exchange factor 4
uniprot_id:Q8WZA2
gene_name:RAPGEF4
protein_type:Unknown
73:
protein_accession:HMDBP02951
name:Steroidogenic factor 1
uniprot_id:Q13285
gene_name:NR5A1
protein_type:Unknown
74:
protein_accession:HMDBP03231
name:Sodium bicarbonate cotransporter 3
uniprot_id:Q9Y6M7
gene_name:SLC4A7
protein_type:Transporter
75:
protein_accession:HMDBP03952
name:Multidrug resistance-associated protein 4
uniprot_id:O15439
gene_name:ABCC4
protein_type:Transporter
76:
protein_accession:HMDBP03958
name:Multidrug resistance-associated protein 5
uniprot_id:O15440
gene_name:ABCC5
protein_type:Transporter
77:
protein_accession:HMDBP04127
name:Adenylate cyclase type 10
uniprot_id:Q96PN6
gene_name:ADCY10
protein_type:Unknown
78:
protein_accession:HMDBP04379
name:Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
uniprot_id:Q9HCR9
gene_name:PDE11A
protein_type:Unknown
79:
protein_accession:HMDBP04457
name:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
uniprot_id:Q8N3E9
gene_name:PLCD3
protein_type:Unknown
80:
protein_accession:HMDBP07316
name:Lysophosphatidic acid receptor 6
uniprot_id:P43657
gene_name:LPAR6
protein_type:Unknown
81:
protein_accession:HMDBP07436
name:A-kinase anchor protein 7 isoforms alpha and beta
uniprot_id:O43687
gene_name:AKAP7
protein_type:Unknown
82:
protein_accession:HMDBP07437
name:A-kinase anchor protein 13
uniprot_id:Q12802
gene_name:AKAP13
protein_type:Unknown
83:
protein_accession:HMDBP07616
name:Cyclic nucleotide-gated cation channel alpha-4
uniprot_id:Q8IV77
gene_name:CNGA4
protein_type:Unknown
84:
protein_accession:HMDBP07632
name:CREB-regulated transcription coactivator 1
uniprot_id:Q6UUV9
gene_name:CRTC1
protein_type:Unknown
85:
protein_accession:HMDBP07633
name:CREB-regulated transcription coactivator 2
uniprot_id:Q53ET0
gene_name:CRTC2
protein_type:Unknown
86:
protein_accession:HMDBP07713
name:Guanine nucleotide-binding protein G(t) subunit alpha-3
uniprot_id:A8MTJ3
gene_name:GNAT3
protein_type:Unknown
87:
protein_accession:HMDBP07953
name:Protein phosphatase 1 regulatory subunit 1A
uniprot_id:Q13522
gene_name:PPP1R1A
protein_type:Unknown
88:
protein_accession:HMDBP07986
name:Solute carrier family 22 member 6
uniprot_id:Q4U2R8
gene_name:SLC22A6
protein_type:Transporter
89:
protein_accession:HMDBP08083
name:Transient receptor potential cation channel subfamily V member 2
uniprot_id:Q9Y5S1
gene_name:TRPV2
protein_type:Unknown
90:
protein_accession:HMDBP08104
name:ATP-binding cassette sub-family C member 11
uniprot_id:Q96J66
gene_name:ABCC11
protein_type:Transporter
91:
protein_accession:HMDBP08105
name:ADM2
uniprot_id:Q7Z4H4
gene_name:ADM2
protein_type:Unknown
92:
protein_accession:HMDBP08106
name:A-kinase anchor protein 7 isoform gamma
uniprot_id:Q9P0M2
gene_name:AKAP7
protein_type:Unknown
93:
protein_accession:HMDBP08107
name:A-kinase anchor protein 2
uniprot_id:Q9Y2D5
gene_name:AKAP2
protein_type:Unknown
94:
protein_accession:HMDBP08108
name:A-kinase anchor protein 5
uniprot_id:P24588
gene_name:AKAP5
protein_type:Unknown
95:
protein_accession:HMDBP08109
name:A-kinase anchor protein 8
uniprot_id:O43823
gene_name:AKAP8
protein_type:Unknown
96:
protein_accession:HMDBP08110
name:Agouti-signaling protein
uniprot_id:P42127
gene_name:ASIP
protein_type:Unknown
97:
protein_accession:HMDBP08111
name:Cyclic AMP-dependent transcription factor ATF-1
uniprot_id:P18846
gene_name:ATF1
protein_type:Unknown
98:
protein_accession:HMDBP08112
name:Cyclic AMP-dependent transcription factor ATF-2
uniprot_id:P15336
gene_name:ATF2
protein_type:Unknown
99:
protein_accession:HMDBP08113
name:Cyclic AMP-dependent transcription factor ATF-3
uniprot_id:P18847
gene_name:ATF3
protein_type:Unknown
100:
protein_accession:HMDBP08114
name:Cyclic AMP-dependent transcription factor ATF-4
uniprot_id:P18848
gene_name:ATF4
protein_type:Unknown
101:
protein_accession:HMDBP08115
name:Cyclic AMP-dependent transcription factor ATF-5
uniprot_id:Q9Y2D1
gene_name:ATF5
protein_type:Unknown
102:
protein_accession:HMDBP08116
name:Cyclic AMP-dependent transcription factor ATF-7
uniprot_id:P17544
gene_name:ATF7
protein_type:Unknown
103:
protein_accession:HMDBP08117
name:Basic leucine zipper transcriptional factor ATF-like
uniprot_id:Q16520
gene_name:BATF
protein_type:Unknown
104:
protein_accession:HMDBP08118
name:Cyclic nucleotide-gated olfactory channel
uniprot_id:Q16280
gene_name:CNGA2
protein_type:Unknown
105:
protein_accession:HMDBP08119
name:Cyclic AMP-responsive element-binding protein 3-like protein 1
uniprot_id:Q96BA8
gene_name:CREB3L1
protein_type:Unknown
106:
protein_accession:HMDBP08120
name:Cyclic AMP-responsive element-binding protein 3-like protein 2
uniprot_id:Q70SY1
gene_name:CREB3L2
protein_type:Unknown
107:
protein_accession:HMDBP08121
name:Cyclic AMP-responsive element-binding protein 3-like protein 3
uniprot_id:Q68CJ9
gene_name:CREB3L3
protein_type:Unknown
108:
protein_accession:HMDBP08122
name:Cyclic AMP-responsive element-binding protein 3
uniprot_id:O43889
gene_name:CREB3
protein_type:Unknown
109:
protein_accession:HMDBP08123
name:Luc7-like protein 3
uniprot_id:O95232
gene_name:LUC7L3
protein_type:Unknown
110:
protein_accession:HMDBP08124
name:CREB-regulated transcription coactivator 3
uniprot_id:Q6UUV7
gene_name:CRTC3
protein_type:Unknown
111:
protein_accession:HMDBP08125
name:Dematin
uniprot_id:Q08495
gene_name:EPB49
protein_type:Unknown
112:
protein_accession:HMDBP08126
name:Erythrocyte membrane protein band 4.2
uniprot_id:P16452
gene_name:EPB42
protein_type:Unknown
113:
protein_accession:HMDBP08127
name:FERM, RhoGEF and pleckstrin domain-containing protein 1
uniprot_id:Q9Y4F1
gene_name:FARP1
protein_type:Unknown
114:
protein_accession:HMDBP08128
name:G-protein coupled bile acid receptor 1
uniprot_id:Q8TDU6
gene_name:GPBAR1
protein_type:Unknown
115:
protein_accession:HMDBP08129
name:Glycoprotein hormone alpha-2
uniprot_id:Q96T91
gene_name:GPHA2
protein_type:Unknown
116:
protein_accession:HMDBP08130
name:Glycoprotein hormone beta-5
uniprot_id:Q86YW7
gene_name:GPHB5
protein_type:Unknown
117:
protein_accession:HMDBP08131
name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
uniprot_id:Q9Y3Q4
gene_name:HCN4
protein_type:Unknown
118:
protein_accession:HMDBP08132
name:Histamine H4 receptor
uniprot_id:Q9H3N8
gene_name:HRH4
protein_type:Unknown
119:
protein_accession:HMDBP08133
name:cAMP-dependent protein kinase inhibitor alpha
uniprot_id:P61925
gene_name:PKIA
protein_type:Unknown
120:
protein_accession:HMDBP08134
name:cAMP-dependent protein kinase inhibitor beta
uniprot_id:Q9C010
gene_name:PKIB
protein_type:Unknown
121:
protein_accession:HMDBP08135
name:cAMP-dependent protein kinase inhibitor gamma
uniprot_id:Q9Y2B9
gene_name:PKIG
protein_type:Unknown
122:
protein_accession:HMDBP08136
name:Jun dimerization protein 2
uniprot_id:Q8WYK2
gene_name:JDP2
protein_type:Unknown
123:
protein_accession:HMDBP08137
name:cAMP-dependent protein kinase type I-beta regulatory subunit
uniprot_id:P31321
gene_name:PRKAR1B
protein_type:Unknown
124:
protein_accession:HMDBP08138
name:cAMP-dependent protein kinase type II-alpha regulatory subunit
uniprot_id:P13861
gene_name:PRKAR2A
protein_type:Unknown
125:
protein_accession:HMDBP08139
name:cAMP-dependent protein kinase type II-beta regulatory subunit
uniprot_id:P31323
gene_name:PRKAR2B
protein_type:Unknown
126:
protein_accession:HMDBP08140
name:Potassium voltage-gated channel subfamily A member 10
uniprot_id:Q16322
gene_name:KCNA10
protein_type:Unknown
127:
protein_accession:HMDBP08141
name:Potassium voltage-gated channel subfamily E member 3
uniprot_id:Q9Y6H6
gene_name:KCNE3
protein_type:Unknown
128:
protein_accession:HMDBP08142
name:Potassium voltage-gated channel subfamily H member 1
uniprot_id:O95259
gene_name:KCNH1
protein_type:Unknown
129:
protein_accession:HMDBP08143
name:Potassium voltage-gated channel subfamily H member 3
uniprot_id:Q9ULD8
gene_name:KCNH3
protein_type:Unknown
130:
protein_accession:HMDBP08144
name:Potassium voltage-gated channel subfamily H member 4
uniprot_id:Q9UQ05
gene_name:KCNH4
protein_type:Unknown
131:
protein_accession:HMDBP08145
name:Potassium voltage-gated channel subfamily H member 5
uniprot_id:Q8NCM2
gene_name:KCNH5
protein_type:Unknown
132:
protein_accession:HMDBP08146
name:Potassium voltage-gated channel subfamily H member 7
uniprot_id:Q9NS40
gene_name:KCNH7
protein_type:Unknown
133:
protein_accession:HMDBP08147
name:Potassium voltage-gated channel subfamily H member 8
uniprot_id:Q96L42
gene_name:KCNH8
protein_type:Unknown
134:
protein_accession:HMDBP08148
name:Leucine zipper putative tumor suppressor 1
uniprot_id:Q9Y250
gene_name:LZTS1
protein_type:Unknown
135:
protein_accession:HMDBP08149
name:Homeobox protein Meis1
uniprot_id:O00470
gene_name:MEIS1
protein_type:Unknown
136:
protein_accession:HMDBP08150
name:Mas-related G-protein coupled receptor member D
uniprot_id:Q8TDS7
gene_name:MRGPRD
protein_type:Unknown
137:
protein_accession:HMDBP08151
name:Mas-related G-protein coupled receptor member X2
uniprot_id:Q96LB1
gene_name:MRGPRX2
protein_type:Unknown
138:
protein_accession:HMDBP08152
name:Myomegalin
uniprot_id:Q5VU43
gene_name:PDE4DIP
protein_type:Unknown
139:
protein_accession:HMDBP08153
name:Na(+)/H(+) exchange regulatory cofactor NHE-RF2
uniprot_id:Q15599
gene_name:SLC9A3R2
protein_type:Unknown
140:
protein_accession:HMDBP08154
name:Non-POU domain-containing octamer-binding protein
uniprot_id:Q15233
gene_name:NONO
protein_type:Unknown
141:
protein_accession:HMDBP08155
name:Pre-B-cell leukemia transcription factor 1
uniprot_id:P40424
gene_name:PBX1
protein_type:Unknown
142:
protein_accession:HMDBP08156
name:Prostaglandin E2 receptor EP2 subtype
uniprot_id:P43116
gene_name:PTGER2
protein_type:Unknown
143:
protein_accession:HMDBP08157
name:Phosducin
uniprot_id:P20941
gene_name:PDC
protein_type:Unknown
144:
protein_accession:HMDBP08158
name:Paired mesoderm homeobox protein 2B
uniprot_id:Q99453
gene_name:PHOX2B
protein_type:Unknown
145:
protein_accession:HMDBP08159
name:Phospholemman
uniprot_id:O00168
gene_name:FXYD1
protein_type:Unknown
146:
protein_accession:HMDBP08160
name:Protein prune homolog
uniprot_id:Q86TP1
gene_name:PRUNE
protein_type:Unknown
147:
protein_accession:HMDBP08161
name:Tyrosine-protein phosphatase non-receptor type 7
uniprot_id:P35236
gene_name:PTPN7
protein_type:Unknown
148:
protein_accession:HMDBP08162
name:Ras-related protein Rap-1b
uniprot_id:P61224
gene_name:RAP1B
protein_type:Unknown
149:
protein_accession:HMDBP08163
name:Ras-related protein Rap-2a
uniprot_id:P10114
gene_name:RAP2A
protein_type:Unknown
150:
protein_accession:HMDBP08164
name:FMRFamide-related peptides
uniprot_id:Q9HCQ7
gene_name:NPVF
protein_type:Unknown
151:
protein_accession:HMDBP08165
name:Rhophilin-2
uniprot_id:Q8IUC4
gene_name:RHPN2
protein_type:Unknown
152:
protein_accession:HMDBP08166
name:Synembryn-B
uniprot_id:Q9NVN3
gene_name:RIC8B
protein_type:Unknown
153:
protein_accession:HMDBP08167
name:Relaxin-3 receptor 1
uniprot_id:Q9NSD7
gene_name:RXFP3
protein_type:Unknown
154:
protein_accession:HMDBP08168
name:Relaxin-3 receptor 2
uniprot_id:Q8TDU9
gene_name:RXFP4
protein_type:Unknown
155:
protein_accession:HMDBP08169
name:Ras-related protein Rap-1b-like protein
uniprot_id:A6NIZ1
gene_name:
protein_type:Unknown
156:
protein_accession:HMDBP08170
name:Rap guanine nucleotide exchange factor 6
uniprot_id:Q8TEU7
gene_name:RAPGEF6
protein_type:Unknown
157:
protein_accession:HMDBP08171
name:40S ribosomal protein S27
uniprot_id:P42677
gene_name:RPS27
protein_type:Unknown
158:
protein_accession:HMDBP08172
name:Relaxin receptor 2
uniprot_id:Q8WXD0
gene_name:RXFP2
protein_type:Unknown
159:
protein_accession:HMDBP08173
name:Solute carrier organic anion transporter family member 4C1
uniprot_id:Q6ZQN7
gene_name:SLCO4C1
protein_type:Transporter
160:
protein_accession:HMDBP08174
name:A-kinase anchor protein SPHKAP
uniprot_id:Q2M3C7
gene_name:SPHKAP
protein_type:Unknown
161:
protein_accession:HMDBP08175
name:Ras GTPase-activating protein SynGAP
uniprot_id:Q96PV0
gene_name:SYNGAP1
protein_type:Unknown
162:
protein_accession:HMDBP08176
name:Transmembrane protein 132A
uniprot_id:Q24JP5
gene_name:TMEM132A
protein_type:Unknown
163:
protein_accession:HMDBP09059
name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
uniprot_id:Q9P1Z3
gene_name:HCN3
protein_type:Unknown
164:
protein_accession:HMDBP09068
name:Solute carrier family 22 member 7
uniprot_id:Q9Y694
gene_name:SLC22A7
protein_type:Transporter
165:
protein_accession:HMDBP10837
name:Cyclic nucleotide-gated cation channel beta-1
uniprot_id:Q14028
gene_name:CNGB1
protein_type:Unknown
蛋白质结合
1:
reference_text:Imashuku S, Todo S, Nakajima F: [Intra-aortic prostaglandin E1 infusion in the treatment of advanced neuroblastoma]. Gan To Kagaku Ryoho. 1983 Sep;10(9):1936-43.
pubmed_id:6311112
2:
reference_text:Wine JJ, Joo NS: Submucosal glands and airway defense. Proc Am Thorac Soc. 2004;1(1):47-53.
pubmed_id:16113412
3:
reference_text:Onali P, Strada SJ, Chang L, Epstein PM, Hersh EM, Thompson WJ: Purification and characterization of high-affinity cyclic adenosine 5'-monophosphate phosphodiesterases from human acute myelogenous leukemic cells. Cancer Res. 1985 Mar;45(3):1384-91.
pubmed_id:2982489
4:
reference_text:Rademaker MT, Charles CJ, Lewis LK, Yandle TG, Cooper GJ, Coy DH, Richards AM, Nicholls MG: Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation. 1997 Sep 16;96(6):1983-90.
pubmed_id:9323090
5:
reference_text:Mashayekhi F, Aghahoseini F, Rezaie A, Zamani MJ, Khorasani R, Abdollahi M: Alteration of cyclic nucleotides levels and oxidative stress in saliva of human subjects with periodontitis. J Contemp Dent Pract. 2005 Nov 15;6(4):46-53.
pubmed_id:16299606
6:
reference_text:Sugo T, Tachimoto H, Chikatsu T, Murakami Y, Kikukawa Y, Sato S, Kikuchi K, Nagi T, Harada M, Ogi K, Ebisawa M, Mori M: Identification of a lysophosphatidylserine receptor on mast cells. Biochem Biophys Res Commun. 2006 Mar 24;341(4):1078-87. Epub 2006 Jan 25.
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