人类代谢组数据库

版本

5.0

创建日期

2005-11-16 15:48:42 UTC

更新日期

2021-09-14 15:47:19 UTC

登录号

HMDB0000050

地位

quantified

二级访问

HMDB0004401

HMDB0004402

HMDB0004421

HMDB00050

HMDB04401

HMDB04402

HMDB04421

名称

Adenosine

描述

Adenosine is a nucleoside that is composed of adenine and D-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. For instance, adenosine plays an important role in energy transfer as adenosine triphosphate (ATP) and adenosine diphosphate (ADP). It also plays a role in signal transduction as cyclic adenosine monophosphate (cAMP). Adenosine itself is both a neurotransmitter and potent vasodilator. When administered intravenously adenosine causes transient heart block in the AV node. Due to the effects of adenosine on AV node-dependent supraventricular tachycardia, adenosine is considered a class V antiarrhythmic agent. Overdoses of adenosine intake (as a drug) can lead to several side effects including chest pain, feeling faint, shortness of breath, and tingling of the senses. Serious side effects include a worsening dysrhythmia and low blood pressure. When present in sufficiently high levels, adenosine can act as an immunotoxin and a metabotoxin. An immunotoxin disrupts, limits the function, or destroys immune cells. A metabotoxin is an endogenous metabolite that causes adverse health effects at chronically high levels. Chronically high levels of adenosine are associated with adenosine deaminase deficiency. Adenosine is a precursor to deoxyadenosine, which is a precursor to dATP. A buildup of dATP in cells inhibits ribonucleotide reductase and prevents DNA synthesis, so cells are unable to divide. Since developing T cells and B cells are some of the most mitotically active cells, they are unable to divide and propagate to respond to immune challenges. High levels of deoxyadenosine also lead to an increase in S-adenosylhomocysteine, which is toxic to immature lymphocytes.

同义词

1:(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

2:6-Amino-9-beta-D-ribofuranosyl-9H-purine

3:9-beta-D-Ribofuranosidoadenine

4:9-beta-D-Ribofuranosyl-9H-purin-6-amine

5:Ade-rib

6:Adenine deoxyribonucleoside

7:Adenocard

8:Adenocor

9:Adenoscan

10:Adenosin

11:Adenyldeoxyriboside

12:Ado

13:beta-D-Adenosine

14:Deoxyadenosine

15:Desoxyadenosine

16:6-Amino-9-b-D-ribofuranosyl-9H-purine

17:6-Amino-9-β-D-ribofuranosyl-9H-purine

18:9-b-D-Ribofuranosidoadenine

19:9-Β-D-ribofuranosidoadenine

20:9-b-D-Ribofuranosyl-9H-purin-6-amine

21:9-Β-D-ribofuranosyl-9H-purin-6-amine

22:b-D-Adenosine

23:Β-D-adenosine

24:1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranose

25:1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-ribofuranose

26:6-Amino-9beta-D-ribofuranosyl-9H-purine

27:6-Amino-9beta-delta-ribofuranosyl-9H-purine

28:9-beta-D-Arabinofuranosyladenine

29:9-beta-D-Ribofuranosyladenine

30:9-beta-delta-Arabinofuranosyladenine

31:9-beta-delta-Ribofuranosidoadenine

32:9-beta-delta-Ribofuranosyl-9H-purin-6-amine

33:9-beta-delta-Ribofuranosyladenine

34:9beta-D-Ribofuranosyl-9H-purin-6-amine

35:9beta-D-Ribofuranosyladenine

36:9beta-delta-Ribofuranosyl-9H-purin-6-amine

37:9beta-delta-Ribofuranosyladenine

38:Adenine nucleoside

39:Adenine riboside

40:Adenine-9beta-D-ribofuranoside

41:Adenine-9beta-delta-ribofuranoside

42:beta-Adenosine

43:beta-delta-Adenosine

44:Boniton

45:Myocol

46:Nucleocardyl

47:Sandesin

化学式

C10H13N5O4

平均分子量

267.2413

等位分子量

267.096753929

化学名称

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

传统名称

adenosine

CAS 登记号

58-61-7

代谢物结构字符串

NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1

inchi标识符

InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

印记键

OIRDTQYFTABQOQ-KQYNXXCUSA-N

分类学

description: belongs to the class of organic compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.

description:Purine nucleosides

kingdom:Organic compounds

super_class:Nucleosides, nucleotides, and analogues

class:Purine nucleosides

sub_class:

molecular_framework:Aromatic heteropolycyclic compounds

1:6-aminopurines

2:Aminopyrimidines and derivatives

3:Azacyclic compounds

4:Glycosylamines

5:Heteroaromatic compounds

6:Hydrocarbon derivatives

7:Imidolactams

8:N-substituted imidazoles

9:Organopnictogen compounds

10:Oxacyclic compounds

11:Pentoses

12:Primary alcohols

13:Primary amines

14:Secondary alcohols

15:Tetrahydrofurans

16:6-aminopurine

17:Alcohol

18:Amine

19:Aminopyrimidine

20:Aromatic heteropolycyclic compound

21:Azacycle

22:Azole

23:Glycosyl compound

24:Heteroaromatic compound

25:Hydrocarbon derivative

26:Imidazole

27:Imidazopyrimidine

28:Imidolactam

29:Monosaccharide

30:N-glycosyl compound

31:N-substituted imidazole

32:Organic nitrogen compound

33:Organic oxygen compound

34:Organoheterocyclic compound

35:Organonitrogen compound

36:Organooxygen compound

37:Organopnictogen compound

38:Oxacycle

39:Pentose monosaccharide

40:Primary alcohol

41:Primary amine

42:Purine

43:Purine nucleoside

44:Pyrimidine

45:Secondary alcohol

46:Tetrahydrofuran

47:Ribonucleosides

48:adenosines

本体论

term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Septic shock

definition:

parent_id:7695

***level:4

type:child

synonym:Endotoxic shock

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Synthetic

definition:A man-made product or sample in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Personal care product

definition:

parent_id:7742

***level:4

type:child

synonym:Pcp

synonym:Toiletries

synonym:Toiletry

synonym:Personal hygiene

synonym:Beautification product

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:All tissues

definition:All tissues in the body of the organism.

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Lysosome

definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).

parent_id:7730

***level:4

type:child

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Indirect biological role

definition:An indirect function of a chemical which affect the physiological state of any organism (apart from the source organism, if of biological source).

parent_id:7671

*level:2

type:parent

term:Immunotoxin

definition:A chemical substance that disrupts, limits the function, or destroys immune cells.

parent_id:7691

**level:3

type:child

term:Metabotoxin

definition:An endogenous metabolite that causes adverse health effects at chronically high levels.

parent_id:7691

**level:3

type:child

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Metabolite

definition:A chemical substance produced during metabolism process, as an intermediate or end-product.

parent_id:7672

**level:3

type:child

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Personal care products

definition:Cosmetics and personal hygene products in which a chemical was incorportaed during the manufacturing process.

parent_id:7678

**level:3

type:child

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Analgesic

definition:A chemical substance that causes analgesia, relief of pain.

parent_id:7679

***level:4

type:child

状态

Solid

实验性质

kind:water_solubility

value:37 mg/mL

source:Human Metabolome Project

kind:logp

value:-1.05

source:HANSCH,C ET AL. (1995)

kind:melting_point

value:235.5 °C

source:

预测性质

kind:logp

value:-1.21

source:ALOGPS

kind:logs

value:-1.28

source:ALOGPS

kind:solubility

value:14 g/L

source:ALOGPS

kind:logp

value:-2.1

source:ChemAxon

kind:pka_strongest_acidic

value:12.45

source:ChemAxon

kind:pka_strongest_basic

value:3.92

source:ChemAxon

kind:iupac

value:(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

source:ChemAxon

kind:average_mass

value:267.2413

source:ChemAxon

kind:mono_mass

value:267.096753929

source:ChemAxon

10:

kind:smiles

value:NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1

source:ChemAxon

11:

kind:formula

value:C10H13N5O4

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

source:ChemAxon

13:

kind:inchikey

value:OIRDTQYFTABQOQ-KQYNXXCUSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:139.54

source:ChemAxon

15:

kind:refractivity

value:63.2

source:ChemAxon

16:

kind:polarizability

value:25.28

source:ChemAxon

17:

kind:rotatable_bond_count

value:2

source:ChemAxon

18:

kind:acceptor_count

value:8

source:ChemAxon

19:

kind:donor_count

value:4

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:3

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

type:Specdb::NmrTwoD

spectrum_id:943

type:Specdb::NmrTwoD

spectrum_id:1111

type:Specdb::CMs

spectrum_id:297

type:Specdb::CMs

spectrum_id:298

type:Specdb::CMs

spectrum_id:299

type:Specdb::CMs

spectrum_id:300

type:Specdb::CMs

spectrum_id:2034

type:Specdb::CMs

spectrum_id:2087

type:Specdb::CMs

spectrum_id:3195

10:

type:Specdb::CMs

spectrum_id:30173

11:

type:Specdb::CMs

spectrum_id:30263

12:

type:Specdb::CMs

spectrum_id:30473

13:

type:Specdb::CMs

spectrum_id:30822

14:

type:Specdb::CMs

spectrum_id:30969

15:

type:Specdb::CMs

spectrum_id:30970

16:

type:Specdb::CMs

spectrum_id:37266

17:

type:Specdb::CMs

spectrum_id:164828

18:

type:Specdb::MsMs

spectrum_id:2658

19:

type:Specdb::MsMs

spectrum_id:2659

20:

type:Specdb::MsMs

spectrum_id:2660

21:

type:Specdb::MsMs

spectrum_id:2661

22:

type:Specdb::MsMs

spectrum_id:2662

23:

type:Specdb::MsMs

spectrum_id:2676

24:

type:Specdb::MsMs

spectrum_id:436593

25:

type:Specdb::MsMs

spectrum_id:436594

26:

type:Specdb::MsMs

spectrum_id:436595

27:

type:Specdb::MsMs

spectrum_id:436596

28:

type:Specdb::MsMs

spectrum_id:436597

29:

type:Specdb::MsMs

spectrum_id:436598

30:

type:Specdb::MsMs

spectrum_id:437084

31:

type:Specdb::MsMs

spectrum_id:437085

32:

type:Specdb::MsMs

spectrum_id:437086

33:

type:Specdb::MsMs

spectrum_id:437087

34:

type:Specdb::MsMs

spectrum_id:437088

35:

type:Specdb::MsMs

spectrum_id:439017

36:

type:Specdb::MsMs

spectrum_id:439597

37:

type:Specdb::MsMs

spectrum_id:439598

38:

type:Specdb::MsMs

spectrum_id:439599

39:

type:Specdb::MsMs

spectrum_id:439600

40:

type:Specdb::MsMs

spectrum_id:439601

41:

type:Specdb::MsMs

spectrum_id:439602

42:

type:Specdb::MsMs

spectrum_id:2231358

43:

type:Specdb::NmrOneD

spectrum_id:1053

44:

type:Specdb::NmrOneD

spectrum_id:1131

45:

type:Specdb::NmrOneD

spectrum_id:141970

46:

type:Specdb::NmrOneD

spectrum_id:141971

47:

type:Specdb::NmrOneD

spectrum_id:141972

48:

type:Specdb::NmrOneD

spectrum_id:141973

49:

type:Specdb::NmrOneD

spectrum_id:141974

50:

type:Specdb::NmrOneD

spectrum_id:141975

51:

type:Specdb::NmrOneD

spectrum_id:141976

52:

type:Specdb::NmrOneD

spectrum_id:141977

53:

type:Specdb::NmrOneD

spectrum_id:141978

54:

type:Specdb::NmrOneD

spectrum_id:141979

55:

type:Specdb::NmrOneD

spectrum_id:141980

56:

type:Specdb::NmrOneD

spectrum_id:141981

57:

type:Specdb::NmrOneD

spectrum_id:141982

58:

type:Specdb::NmrOneD

spectrum_id:141983

59:

type:Specdb::NmrOneD

spectrum_id:141984

60:

type:Specdb::NmrOneD

spectrum_id:141985

61:

type:Specdb::NmrOneD

spectrum_id:141986

62:

type:Specdb::NmrOneD

spectrum_id:141987

63:

type:Specdb::NmrOneD

spectrum_id:141988

64:

type:Specdb::NmrOneD

spectrum_id:141989

65:

type:Specdb::NmrOneD

spectrum_id:166516

光谱

生物学性质

cellular:(1):Extracellular

cellular:(2):Lysosome

cellular:(3):Mitochondria

biospecimen:(1):Blood

biospecimen:(2):Breast Milk

biospecimen:(3):Cellular Cytoplasm

biospecimen:(4):Cerebrospinal Fluid (CSF)

biospecimen:(5):Feces

biospecimen:(6):Saliva

biospecimen:(7):Urine

tissue:(1):All Tissues

tissue:(2):Placenta

[1]:

name:Adenine phosphoribosyltransferase deficiency (APRT)

smpdb_id:SMP00535

kegg_map_id:

[2]:

name:Adenosine Deaminase Deficiency

smpdb_id:SMP00144

kegg_map_id:

[3]:

name:Adenylosuccinate Lyase Deficiency

smpdb_id:SMP00167

kegg_map_id:

[4]:

name:AICA-Ribosiduria

smpdb_id:SMP00168

kegg_map_id:

[5]:

name:Azathioprine Action Pathway

smpdb_id:SMP00427

kegg_map_id:

[6]:

name:Cystathionine Beta-Synthase Deficiency

smpdb_id:SMP00177

kegg_map_id:

[7]:

name:Glycine N-methyltransferase Deficiency

smpdb_id:SMP00222

kegg_map_id:

[8]:

name:Glycine, serine and threonine metabolism

smpdb_id:

kegg_map_id:map00260

[9]:

name:Gout or Kelley-Seegmiller Syndrome

smpdb_id:SMP00365

kegg_map_id:

[10]:

name:Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type

smpdb_id:SMP00570

kegg_map_id:

[11]:

name:Hypermethioninemia

smpdb_id:SMP00341

kegg_map_id:

[12]:

name:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

smpdb_id:SMP00320

kegg_map_id:

[13]:

name:Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

smpdb_id:SMP00321

kegg_map_id:

[14]:

name:Lesch-Nyhan Syndrome (LNS)

smpdb_id:SMP00364

kegg_map_id:

[15]:

name:Mercaptopurine Action Pathway

smpdb_id:SMP00428

kegg_map_id:

[16]:

name:Methionine Adenosyltransferase Deficiency

smpdb_id:SMP00221

kegg_map_id:

[17]:

name:Methionine Metabolism

smpdb_id:SMP00033

kegg_map_id:map00270

[18]:

name:Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)

smpdb_id:SMP00340

kegg_map_id:

[19]:

name:Mitochondrial DNA depletion syndrome

smpdb_id:SMP00536

kegg_map_id:

[20]:

name:Molybdenum Cofactor Deficiency

smpdb_id:SMP00203

kegg_map_id:

[21]:

name:Myoadenylate deaminase deficiency

smpdb_id:SMP00537

kegg_map_id:

[22]:

name:Purine metabolism

smpdb_id:

kegg_map_id:map00230

[23]:

name:Purine Nucleoside Phosphorylase Deficiency

smpdb_id:SMP00210

kegg_map_id:

[24]:

name:S-Adenosylhomocysteine (SAH) Hydrolase Deficiency

smpdb_id:SMP00214

kegg_map_id:

[25]:

name:Selenocompound metabolism

smpdb_id:

kegg_map_id:map00450

[26]:

name:Thioguanine Action Pathway

smpdb_id:SMP00430

kegg_map_id:

[27]:

name:Xanthine Dehydrogenase Deficiency (Xanthinuria)

smpdb_id:SMP00220

kegg_map_id:

[28]:

name:Xanthinuria type I

smpdb_id:SMP00512

kegg_map_id:

[29]:

name:Xanthinuria type II

smpdb_id:SMP00513

kegg_map_id:

正常浓度

biospecimen:Blood

concentration_value:0.505 +/- 0.142

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:5.66 +/- 1.71

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:0.285 +/- 0.060

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:0.2 (0.1-0.3)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:0.0425 +/- 0.0029

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:0.31 +/- 0.29

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Breast Milk

concentration_value:2.96 +/- 5.88

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

biospecimen:Cellular Cytoplasm

concentration_value:1.20 (0.90-1.50)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

10:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.01 +/- 0.002

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

11:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0 - 0.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

12:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

13:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

14:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

15:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

16:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

17:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

18:

biospecimen:Saliva

concentration_value:0.38 +/- 0.28

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

19:

biospecimen:Saliva

concentration_value:0.24 +/- 0.32

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

20:

biospecimen:Saliva

concentration_value:0.242 +/- 0.133

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

21:

biospecimen:Saliva

concentration_value:0.306 +/- 0.156

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

22:

biospecimen:Urine

concentration_value:0.3.4

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

23:

biospecimen:Urine

concentration_value:0-3.8

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

24:

biospecimen:Urine

concentration_value:0.17

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

25:

biospecimen:Urine

concentration_value:<2

concentration_units:umol/mmol creatinine

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

26:

biospecimen:Urine

concentration_value:1.4 (0.9-2.3)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

27:

biospecimen:Urine

concentration_value:0-11

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 18 years old)

subject_sex:Both

subject_condition:Normal

28:

biospecimen:Urine

concentration_value:9.3 +/- 8.044

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

29:

biospecimen:Urine

concentration_value:4.7+/-7.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

30:

biospecimen:Urine

concentration_value:17.5+/-14.6

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

31:

biospecimen:Urine

concentration_value:0.2

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

32:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Urine

concentration_value:0.50 (0.09-0.92)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

异常浓度

biospecimen:Blood

concentration_value:0.126 +/- 0.018

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Septic shock

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

biospecimen:Saliva

concentration_value:0.40 +/- 0.20

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

biospecimen:Saliva

concentration_value:0.48 +/- 0.32

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

10:

biospecimen:Saliva

concentration_value:0.30 +/- 0.08

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

11:

biospecimen:Urine

concentration_value:6.3-7.2

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Both

patient_information:Adenylosuccinase deficiency

12:

biospecimen:Urine

concentration_value:7.1

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Adenosine kinase deficiency

13:

biospecimen:Urine

concentration_value:9.9

concentration_units:umol/mmol creatinine

patient_age:Adolescent (13-18 years old)

patient_sex:Female

patient_information:Adenosine kinase deficiency

14:

biospecimen:Urine

concentration_value:3.329 +/- 1.977

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

疾病参考

name:Septic shock

omim_id:

[1]:

reference_text:Kaufmann I, Hoelzl A, Schliephake F, Hummel T, Chouker A, Lysenko L, Peter K, Thiel M: Effects of adenosine on functions of polymorphonuclear leukocytes from patients with septic shock. Shock. 2007 Jan;27(1):25-31.

pubmed_id:17172976

[2]:

reference_text:Galley HF, Le Cras AE, Yassen K, Grant IS, Webster NR: Circulating tetrahydrobiopterin concentrations in patients with septic shock. Br J Anaesth. 2001 Apr;86(4):578-80.

pubmed_id:11573638

[3]:

reference_text:Jabs CM, Sigurdsson GH, Neglen P: Plasma levels of high-energy compounds compared with severity of illness in critically ill patients in the intensive care unit. Surgery. 1998 Jul;124(1):65-72.

pubmed_id:9663253

name:Irritable bowel syndrome

omim_id:

[1]:

reference_text:Bearcroft CP, Perrett D, Farthing MJ: Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut. 1998 Jan;42(1):42-6.

pubmed_id:9505884

[2]:

reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.

pubmed_id:8723414

[3]:

reference_text:Ponnusamy K, Choi JN, Kim J, Lee SY, Lee CH: Microbial community and metabolomic comparison of irritable bowel syndrome faeces. J Med Microbiol. 2011 Jun;60(Pt 6):817-27. doi: 10.1099/jmm.0.028126-0. Epub 2011 Feb 17.

pubmed_id:21330412

[4]:

reference_text:Le Gall G, Noor SO, Ridgway K, Scovell L, Jamieson C, Johnson IT, Colquhoun IJ, Kemsley EK, Narbad A: Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J Proteome Res. 2011 Sep 2;10(9):4208-18. doi: 10.1021/pr2003598. Epub 2011 Aug 8.

pubmed_id:21761941

[5]:

reference_text:Hong YS, Hong KS, Park MH, Ahn YT, Lee JH, Huh CS, Lee J, Kim IK, Hwang GS, Kim JS: Metabonomic understanding of probiotic effects in humans with irritable bowel syndrome. J Clin Gastroenterol. 2011 May-Jun;45(5):415-25. doi: 10.1097/MCG.0b013e318207f76c.

pubmed_id:21494186

[6]:

reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.

pubmed_id:23867873

[7]:

reference_text:Zeber-Lubecka N, Kulecka M, Ambrozkiewicz F, Paziewska A, Goryca K, Karczmarski J, Rubel T, Wojtowicz W, Mlynarz P, Marczak L, Tomecki R, Mikula M, Ostrowski J: Limited prolonged effects of rifaximin treatment on irritable bowel syndrome-related differences in the fecal microbiome and metabolome. Gut Microbes. 2016 Sep 2;7(5):397-413. doi: 10.1080/19490976.2016.1215805. Epub 2016 Jul 26.

pubmed_id:27662586

name:Crohn's disease

omim_id:266600

[1]:

reference_text:Lapidus A, Akerlund JE, Einarsson C: Gallbladder bile composition in patients with Crohn 's disease. World J Gastroenterol. 2006 Jan 7;12(1):70-4.

pubmed_id:16440420

[2]:

reference_text:Ehrenpreis ED, Salvino M, Craig RM: Improving the serum D-xylose test for the identification of patients with small intestinal malabsorption. J Clin Gastroenterol. 2001 Jul;33(1):36-40.

pubmed_id:11418788

[3]:

pubmed_id:8723414

[4]:

reference_text:Williams HR, Cox IJ, Walker DG, North BV, Patel VM, Marshall SE, Jewell DP, Ghosh S, Thomas HJ, Teare JP, Jakobovits S, Zeki S, Welsh KI, Taylor-Robinson SD, Orchard TR: Characterization of inflammatory bowel disease with urinary metabolic profiling. Am J Gastroenterol. 2009 Jun;104(6):1435-44. doi: 10.1038/ajg.2009.175. Epub 2009 Apr 28.

pubmed_id:19491857

[5]:

reference_text:Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y: Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb;6(2):546-51.

pubmed_id:17269711

[6]:

reference_text:Ahmed I, Greenwood R, Costello Bde L, Ratcliffe NM, Probert CS: An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PLoS One. 2013;8(3):e58204. doi: 10.1371/journal.pone.0058204. Epub 2013 Mar 13.

pubmed_id:23516449

[7]:

pubmed_id:23867873

[8]:

reference_text:De Preter V, Machiels K, Joossens M, Arijs I, Matthys C, Vermeire S, Rutgeerts P, Verbeke K: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015 Mar;64(3):447-58. doi: 10.1136/gutjnl-2013-306423. Epub 2014 May 8.

pubmed_id:24811995

[9]:

reference_text:Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, Gunther U, Nielsen OH: Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics. 2015;11:122-133. Epub 2014 Jun 1.

pubmed_id:25598765

[10]:

reference_text:Ahmed I, Greenwood R, Costello B, Ratcliffe N, Probert CS: Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Aliment Pharmacol Ther. 2016 Mar;43(5):596-611. doi: 10.1111/apt.13522. Epub 2016 Jan 25.

pubmed_id:26806034

[11]:

reference_text:Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.

pubmed_id:26848182

[12]:

reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.

pubmed_id:27609529

[13]:

reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.

pubmed_id:28842642

name:Ulcerative colitis

omim_id:

[1]:

reference_text:Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. doi: 10.1093/nar/gkq1126. Epub 2010 Nov 8.

pubmed_id:21059682

[2]:

reference_text:Almer S, Andersson T, Strom M: Pharmacokinetics of tranexamic acid in patients with ulcerative colitis and in healthy volunteers after the single instillation of 2 g rectally. J Clin Pharmacol. 1992 Jan;32(1):49-54.

pubmed_id:1740537

[3]:

pubmed_id:17269711

[4]:

reference_text:Garner CE, Smith S, de Lacy Costello B, White P, Spencer R, Probert CS, Ratcliffe NM: Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB J. 2007 Jun;21(8):1675-88. Epub 2007 Feb 21.

pubmed_id:17314143

[5]:

pubmed_id:21761941

[6]:

pubmed_id:23516449

[7]:

pubmed_id:23867873

[8]:

pubmed_id:24811995

[9]:

pubmed_id:25598765

[10]:

pubmed_id:26806034

[11]:

pubmed_id:26848182

[12]:

pubmed_id:27609529

[13]:

pubmed_id:28842642

name:Colorectal cancer

omim_id:114500

[1]:

reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.

pubmed_id:7482520

[2]:

reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.

pubmed_id:19006102

[3]:

reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.

pubmed_id:23940645

[4]:

reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.

pubmed_id:24424155

[5]:

reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.

pubmed_id:20156336

[6]:

reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.

pubmed_id:19678709

[7]:

reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.

pubmed_id:22148915

[8]:

reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.

pubmed_id:25105552

[9]:

reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.

pubmed_id:21773981

[10]:

reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.

pubmed_id:25037050

[11]:

reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.

pubmed_id:27015276

[12]:

reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.

pubmed_id:27107423

[13]:

reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.

pubmed_id:27275383

[14]:

reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.

pubmed_id:28587349

[15]:

reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984

name:Alzheimer's disease

omim_id:104300

[1]:

reference_text:Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10.

pubmed_id:17031479

[2]:

reference_text:Selley ML, Close DR, Stern SE: The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging. 2002 May-Jun;23(3):383-8.

pubmed_id:11959400

[3]:

reference_text:Shetty HU, Holloway HW, Schapiro MB: Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem. 1996 Feb;42(2):298-302.

pubmed_id:8595727

[4]:

reference_text:Jia JP, Jia JM, Zhou WD, Xu M, Chu CB, Yan X, Sun YX: Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. Chin Med J (Engl). 2004 Aug;117(8):1161-4.

pubmed_id:15361288

[5]:

reference_text:Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4.

pubmed_id:9693263

[6]:

reference_text:Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J: Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303.

pubmed_id:15465626

[7]:

reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.

pubmed_id:15061359

[8]:

reference_text:Raskind MA, Peskind ER, Holmes C, Goldstein DS: Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Biol Psychiatry. 1999 Sep 15;46(6):756-65.

pubmed_id:10494443

[9]:

reference_text:Lovell MA, Markesbery WR: Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch Neurol. 2001 Mar;58(3):392-6.

pubmed_id:11255442

[10]:

reference_text:Bar KJ, Franke S, Wenda B, Muller S, Kientsch-Engel R, Stein G, Sauer H: Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia. Neurobiol Aging. 2003 Mar-Apr;24(2):333-8.

pubmed_id:12498967

[11]:

reference_text:Serot JM, Barbe F, Arning E, Bottiglieri T, Franck P, Montagne P, Nicolas JP: Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1585-7.

pubmed_id:16227558

[12]:

reference_text:Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm (Vienna). 1998;105(4-5):479-88.

pubmed_id:9720975

[13]:

reference_text:Molina JA, Jimenez-Jimenez FJ, Hernanz A, Fernandez-Vivancos E, Medina S, de Bustos F, Gomez-Escalonilla C, Sayed Y: Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease. J Neural Transm (Vienna). 2002 Jul;109(7-8):1035-44.

pubmed_id:12111441

[14]:

reference_text:Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203.

pubmed_id:16244393

[15]:

reference_text:Kristensen MO, Gulmann NC, Christensen JE, Ostergaard K, Rasmussen K: Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand. 1993 Jun;87(6):475-81.

pubmed_id:8356878

[16]:

reference_text:Abe T, Tohgi H, Isobe C, Murata T, Sato C: Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.

pubmed_id:12391605

[17]:

reference_text:Reichman ME, Judd JT, Longcope C, Schatzkin A, Clevidence BA, Nair PP, Campbell WS, Taylor PR: Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst. 1993 May 5;85(9):722-7.

pubmed_id:8478958

[18]:

reference_text:Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T: Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011 Apr 15;303(1-2):95-9. doi: 10.1016/j.jns.2011.01.003. Epub 2011 Feb 2.

pubmed_id:21292280

[19]:

reference_text:Motawaj M, Peoc'h K, Callebert J, Arrang JM: CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease. J Alzheimers Dis. 2010;22(3):861-71. doi: 10.3233/JAD-2010-100381.

pubmed_id:20858978

[20]:

reference_text:Smach MA, Jacob N, Golmard JL, Charfeddine B, Lammouchi T, Ben Othman L, Dridi H, Bennamou S, Limem K: Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study. Eur Neurol. 2011;65(5):270-8. doi: 10.1159/000326301. Epub 2011 Apr 8.

pubmed_id:21474939

[21]:

reference_text:Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, Blom H, Stoffel-Wagner B, Kolsch H, Weller M, Jessen F: S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 2010;7(6):373-8. doi: 10.1159/000309657. Epub 2010 Jun 3.

pubmed_id:20523031

[22]:

reference_text:Rosler N, Wichart I, Jellinger KA: Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients. J Neural Transm (Vienna). 2001;108(2):231-46.

pubmed_id:11314776

[23]:

reference_text:Sunderland T, Berrettini WH, Molchan SE, Lawlor BA, Martinez RA, Vitiello B, Tariot PN, Cohen RM: Reduced cerebrospinal fluid dynorphin A1-8 in Alzheimer's disease. Biol Psychiatry. 1991 Jul 1;30(1):81-7.

pubmed_id:1716470

[24]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

name:Frontotemporal dementia

omim_id:600274

[1]:

pubmed_id:23857558

name:Lewy body disease

omim_id:

[1]:

pubmed_id:23857558

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

10:

name:Adenosine kinase deficiency

omim_id:614300

[1]:

reference_text:Bjursell MK, Blom HJ, Cayuela JA, Engvall ML, Lesko N, Balasubramaniam S, Brandberg G, Halldin M, Falkenberg M, Jakobs C, Smith D, Struys E, von Dobeln U, Gustafsson CM, Lundeberg J, Wedell A: Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. Am J Hum Genet. 2011 Oct 7;89(4):507-15. doi: 10.1016/j.ajhg.2011.09.004. Epub 2011 Sep 28.

pubmed_id:21963049

11:

name:Adenylosuccinate lyase deficiency

omim_id:103050

[1]:

reference_text:Marinaki AM, Champion M, Kurian MA, Simmonds HA, Marie S, Vincent MF, van den Berghe G, Duley JA, Fairbanks LD: Adenylosuccinate lyase deficiency--first British case. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1231-3.

pubmed_id:15571235

[2]:

reference_text:Wevers RA, Engelke UF, Moolenaar SH, Brautigam C, de Jong JG, Duran R, de Abreu RA, van Gennip AH: 1H-NMR spectroscopy of body fluids: inborn errors of purine and pyrimidine metabolism. Clin Chem. 1999 Apr;45(4):539-48.

pubmed_id:10102915

[3]:

reference_text:Donti TR, Cappuccio G, Hubert L, Neira J, Atwal PS, Miller MJ, Cardon AL, Sutton VR, Porter BE, Baumer FM, Wangler MF, Sun Q, Emrick LT, Elsea SH: Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum. Mol Genet Metab Rep. 2016 Jul 27;8:61-6. doi: 10.1016/j.ymgmr.2016.07.007. eCollection 2016 Sep.

pubmed_id:27504266

KEGG数据库编号

C00212

DrugBank数据库编号

DB00640

foodb数据库编号

FDB003554

ChemSpider数据库编号

54923

公共化学化合物编号

60961

PDB数据库编号

生物利益的化学实体数据库编号

16335

knapsack数据库编号

C00007444

维基百科编号

Adenosine

代谢途径的数据库编号

ADENOSINE

苯酚资源管理器化合物数据库编号

比格数据库编号

34273

梅林编号

虚拟机身份证编号

ADN

fbonto数据库编号

综合参考

Liao, Ben-ren; Yuan, Zhen-wen. Synthesis of adenosine from inosine. Huaxue Shiji (2006), 28(10), 633-634.

一般参考

protein_accession:HMDBP00001

name:5'-nucleotidase

uniprot_id:P21589

gene_name:NT5E

protein_type:Unknown

protein_accession:HMDBP00004

name:Cytosolic 5'-nucleotidase 1B

uniprot_id:Q96P26

gene_name:NT5C1B

protein_type:Unknown

protein_accession:HMDBP00005

name:Cytosolic 5'-nucleotidase 1A

uniprot_id:Q9BXI3

gene_name:NT5C1A

protein_type:Unknown

protein_accession:HMDBP00006

name:5'(3')-deoxyribonucleotidase, cytosolic type

uniprot_id:Q8TCD5

gene_name:NT5C

protein_type:Unknown

protein_accession:HMDBP00007

name:Deoxycytidine kinase

uniprot_id:P27707

gene_name:DCK

protein_type:Enzyme

protein_accession:HMDBP00008

name:5'(3')-deoxyribonucleotidase, mitochondrial

uniprot_id:Q9NPB1

gene_name:NT5M

protein_type:Unknown

protein_accession:HMDBP00640

name:Adenosine kinase

uniprot_id:P55263

gene_name:ADK

protein_type:Unknown

protein_accession:HMDBP00661

name:Putative adenosylhomocysteinase 3

uniprot_id:Q96HN2

gene_name:AHCYL2

protein_type:Unknown

protein_accession:HMDBP00662

name:Adenosylhomocysteinase

uniprot_id:P23526

gene_name:AHCY

protein_type:Unknown

10:

protein_accession:HMDBP00663

name:Putative adenosylhomocysteinase 2

uniprot_id:O43865

gene_name:AHCYL1

protein_type:Unknown

11:

protein_accession:HMDBP00664

name:Adenosine deaminase

uniprot_id:P00813

gene_name:ADA

protein_type:Enzyme

12:

protein_accession:HMDBP01650

name:Adenosine receptor A1

uniprot_id:P30542

gene_name:ADORA1

protein_type:Enzyme

13:

protein_accession:HMDBP01652

name:Adenosine receptor A2a

uniprot_id:P29274

gene_name:ADORA2A

protein_type:Enzyme

14:

protein_accession:HMDBP01655

name:Adenosine receptor A3

uniprot_id:P33765

gene_name:ADORA3

protein_type:Enzyme

15:

protein_accession:HMDBP01656

name:Adenosine receptor A2b

uniprot_id:P29275

gene_name:ADORA2B

protein_type:Enzyme

16:

protein_accession:HMDBP03189

name:Cytosolic 5'-nucleotidase 3

uniprot_id:Q9H0P0

gene_name:NT5C3

protein_type:Enzyme

17:

protein_accession:HMDBP03254

name:Adenosine 3'-phospho 5'-phosphosulfate transporter 1

uniprot_id:Q8TB61

gene_name:SLC35B2

protein_type:Enzyme

18:

protein_accession:HMDBP03750

name:Cytosolic purine 5'-nucleotidase

uniprot_id:P49902

gene_name:NT5C2

protein_type:Unknown

19:

protein_accession:HMDBP03752

name:Purine nucleoside phosphorylase

uniprot_id:P00491

gene_name:PNP

protein_type:Enzyme

20:

protein_accession:HMDBP10798

name:Adenosine 3'-phospho 5'-phosphosulfate transporter 2

uniprot_id:Q9H1N7

gene_name:SLC35B3

protein_type:Unknown

21:

protein_accession:HMDBP11629

name:Adenosine deaminase CECR1

uniprot_id:Q9NZK5

gene_name:CECR1

protein_type:Unknown

蛋白质结合

reference_text:Eells JT, Spector R: Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma. Neurochem Res. 1983 Nov;8(11):1451-7.

pubmed_id:6656991

reference_text:Lee SH, Jung BH, Kim SY, Chung BC: A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7.

pubmed_id:15116424

reference_text:Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18.

pubmed_id:15882454

reference_text:Skalhegg BS, Funderud A, Henanger HH, Hafte TT, Larsen AC, Kvissel AK, Eikvar S, Orstavik S: Protein kinase A (PKA)--a potential target for therapeutic intervention of dysfunctional immune cells. Curr Drug Targets. 2005 Sep;6(6):655-64.

pubmed_id:16178799

reference_text:Maytin M, Colucci WS: Cardioprotection: a new paradigm in the management of acute heart failure syndromes. Am J Cardiol. 2005 Sep 19;96(6A):26G-31G.

pubmed_id:16181820

reference_text:Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS, Scott JD: The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature. 2005 Sep 22;437(7058):574-8.

pubmed_id:16177794

reference_text:Gheorghiade M, Teerlink JR, Mebazaa A: Pharmacology of new agents for acute heart failure syndromes. Am J Cardiol. 2005 Sep 19;96(6A):68G-73G.

pubmed_id:16181825

reference_text:Jansen RW, Kruijt JK, van Berkel TJ, Meijer DK: Coupling of the antiviral drug ara-AMP to lactosaminated albumin leads to specific uptake in rat and human hepatocytes. Hepatology. 1993 Jul;18(1):146-52.

pubmed_id:7686877

reference_text:Ballantyne PJ: Social context and outcomes for the ageing breast cancer patient: considerations for clinical practitioners. J Clin Nurs. 2004 Mar;13(3a):11-21.

pubmed_id:15028034

10:

reference_text:Yamamoto T, Moriwaki Y, Takahashi S, Fujita T, Tsutsumi Z, Yamakita J, Shimizu K, Shiota M, Ohta S, Higashino K: Determination of adenosine and deoxyadenosine in urine by high-performance liquid chromatography with column switching. J Chromatogr B Biomed Sci Appl. 1998 Nov 20;719(1-2):55-61.

pubmed_id:9869364

11:

reference_text:Koeris M, Funke L, Shrestha J, Rich A, Maas S: Modulation of ADAR1 editing activity by Z-RNA in vitro. Nucleic Acids Res. 2005 Sep 21;33(16):5362-70. Print 2005.

pubmed_id:16177183

12:

reference_text:Vidotto C, Fousert D, Akkermann M, Griesmacher A, Muller MM: Purine and pyrimidine metabolites in children's urine. Clin Chim Acta. 2003 Sep;335(1-2):27-32.

pubmed_id:12927681

13:

reference_text:Dunne VG, Bhattachayya S, Besser M, Rae C, Griffin JL: Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR study. NMR Biomed. 2005 Feb;18(1):24-33.

pubmed_id:15455468

14:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

版本
创建日期
更新日期
登录号
地位
二级访问
名称
描述
同义词
化学式
平均分子量
等位分子量
化学名称
传统名称
CAS 登记号
代谢物结构字符串
inchi标识符
印记键
分类学
本体论
状态
实验性质
预测性质
光谱
生物学性质
正常浓度
异常浓度
疾病参考
KEGG数据库编号
DrugBank数据库编号
foodb数据库编号
ChemSpider数据库编号
公共化学化合物编号
PDB数据库编号
生物利益的化学实体数据库编号
knapsack数据库编号
维基百科编号
代谢途径的数据库编号
苯酚资源管理器化合物数据库编号
比格数据库编号
梅林编号
虚拟机身份证编号
fbonto数据库编号
综合参考
一般参考
蛋白质结合

目录