版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-10-13 04:18:52 UTC
登录号
HMDB0000002
地位
quantified
二级访问
HMDB00002

HMDB0060172

HMDB60172

名称
1,3-Diaminopropane
描述
1,3-Diaminopropane, also known as DAP or trimethylenediamine, belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing a primary aliphatic amine group. 1,3-Diaminopropane is a stable, flammable, and highly hygroscopic fluid. It is a polyamine that is normally quite toxic if swallowed, inhaled, or absorbed through the skin. It is a catabolic byproduct of spermidine. It is also a precursor in the enzymatic synthesis of beta-alanine. 1,3-Diaminopropane is involved in the arginine/proline metabolic pathways and the beta-alanine metabolic pathway. 1,3-Diaminopropane has been detected, but not quantified in, several different foods, such as cassava, shiitakes, oyster mushrooms, muscadine grapes, and cinnamons. This could make 1,3-diaminopropane a potential biomarker for the consumption of these foods.
同义词
1:1,3-Propanediamine

2:1,3-Propylenediamine

3:Propane-1,3-diamine

4:tn

5:Trimethylenediamine

6:1,3-Diaminepropane

7:Trimethylenediamine dihydrochloride

8:Trimethylenediamine hydrochloride

9:1,3-diamino-N-Propane

10:1,3-Trimethylenediamine

11:3-Aminopropylamine

12:a,W-Propanediamine

13:1,3-Diaminopropane

化学式
C3H10N2
平均分子量
74.1249
等位分子量
74.08439833
化学名称
propane-1,3-diamine
传统名称
α,ω-propanediamine
CAS 登记号
109-76-2
代谢物结构字符串
NCCCN
inchi标识符
InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2
印记键
XFNJVJPLKCPIBV-UHFFFAOYSA-N
分类学
description: belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing an primary aliphatic amine group.

description:Monoalkylamines

kingdom:Organic compounds

super_class:Organic nitrogen compounds

class:Organonitrogen compounds

sub_class:Amines

molecular_framework:Aliphatic acyclic compounds

1:Hydrocarbon derivatives

2:Organopnictogen compounds

3:Aliphatic acyclic compound

4:Hydrocarbon derivative

5:Organopnictogen compound

6:Primary aliphatic amine

7:a small molecule

8:alkane-alpha,omega-diamine

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Cancer

definition:A group of disorders characterized by the presense of malignant neoplasm.

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

状态
Liquid
实验性质
1:

kind:water_solubility

value:1e+006 mg/L @ 25 °C (est)

source:The Good Scents Company Information System

2:

kind:logp

value:-1.43

source:HANSCH,C ET AL. (1995)

3:

kind:melting_point

value:-12 °C

source:

4:

kind:boiling_point

value:139.80 °C. @ 760.00 mm Hg

source:The Good Scents Company Information System

预测性质
1:

kind:logp

value:-1.41

source:ALOGPS

2:

kind:logs

value:0.77

source:ALOGPS

3:

kind:solubility

value:437 g/L

source:ALOGPS

4:

kind:logp

value:-1.4

source:ChemAxon

5:

kind:pka_strongest_basic

value:10.17

source:ChemAxon

6:

kind:iupac

value:propane-1,3-diamine

source:ChemAxon

7:

kind:average_mass

value:74.1249

source:ChemAxon

8:

kind:mono_mass

value:74.08439833

source:ChemAxon

9:

kind:smiles

value:NCCCN

source:ChemAxon

10:

kind:formula

value:C3H10N2

source:ChemAxon

11:

kind:inchi

value:InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2

source:ChemAxon

12:

kind:inchikey

value:XFNJVJPLKCPIBV-UHFFFAOYSA-N

source:ChemAxon

13:

kind:polar_surface_area

value:52.04

source:ChemAxon

14:

kind:refractivity

value:22.73

source:ChemAxon

15:

kind:polarizability

value:9.06

source:ChemAxon

16:

kind:rotatable_bond_count

value:2

source:ChemAxon

17:

kind:acceptor_count

value:2

source:ChemAxon

18:

kind:donor_count

value:2

source:ChemAxon

19:

kind:physiological_charge

value:2

source:ChemAxon

20:

kind:formal_charge

value:0

source:ChemAxon

21:

kind:number_of_rings

value:0

source:ChemAxon

22:

kind:bioavailability

value:Yes

source:ChemAxon

23:

kind:rule_of_five

value:Yes

source:ChemAxon

24:

kind:ghose_filter

value:No

source:ChemAxon

25:

kind:veber_rule

value:No

source:ChemAxon

26:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::EiMs

spectrum_id:1533

2:

type:Specdb::NmrTwoD

spectrum_id:916

3:

type:Specdb::NmrTwoD

spectrum_id:934

4:

type:Specdb::NmrOneD

spectrum_id:1023

5:

type:Specdb::NmrOneD

spectrum_id:3789

6:

type:Specdb::NmrOneD

spectrum_id:4048

7:

type:Specdb::NmrOneD

spectrum_id:4740

8:

type:Specdb::CMs

spectrum_id:272

9:

type:Specdb::CMs

spectrum_id:273

10:

type:Specdb::CMs

spectrum_id:274

11:

type:Specdb::CMs

spectrum_id:275

12:

type:Specdb::CMs

spectrum_id:1311

13:

type:Specdb::CMs

spectrum_id:3286

14:

type:Specdb::CMs

spectrum_id:27666

15:

type:Specdb::CMs

spectrum_id:28730

16:

type:Specdb::CMs

spectrum_id:28772

17:

type:Specdb::CMs

spectrum_id:30163

18:

type:Specdb::CMs

spectrum_id:30249

19:

type:Specdb::CMs

spectrum_id:30410

20:

type:Specdb::CMs

spectrum_id:30742

21:

type:Specdb::CMs

spectrum_id:30942

22:

type:Specdb::CMs

spectrum_id:32035

23:

type:Specdb::CMs

spectrum_id:32036

24:

type:Specdb::CMs

spectrum_id:131464

25:

type:Specdb::CMs

spectrum_id:139198

26:

type:Specdb::MsMs

spectrum_id:4

27:

type:Specdb::MsMs

spectrum_id:5

28:

type:Specdb::MsMs

spectrum_id:6

29:

type:Specdb::MsMs

spectrum_id:2508

30:

type:Specdb::MsMs

spectrum_id:2509

31:

type:Specdb::MsMs

spectrum_id:2510

32:

type:Specdb::MsMs

spectrum_id:2511

33:

type:Specdb::MsMs

spectrum_id:2512

34:

type:Specdb::MsMs

spectrum_id:2513

35:

type:Specdb::MsMs

spectrum_id:2514

36:

type:Specdb::MsMs

spectrum_id:2515

37:

type:Specdb::MsMs

spectrum_id:20192

38:

type:Specdb::MsMs

spectrum_id:20193

39:

type:Specdb::MsMs

spectrum_id:20194

40:

type:Specdb::MsMs

spectrum_id:20441

41:

type:Specdb::MsMs

spectrum_id:20442

42:

type:Specdb::MsMs

spectrum_id:20443

43:

type:Specdb::MsMs

spectrum_id:21743

44:

type:Specdb::MsMs

spectrum_id:21744

45:

type:Specdb::MsMs

spectrum_id:21745

46:

type:Specdb::MsMs

spectrum_id:21992

47:

type:Specdb::MsMs

spectrum_id:21993

48:

type:Specdb::MsMs

spectrum_id:21994

49:

type:Specdb::MsMs

spectrum_id:445975

50:

type:Specdb::MsMs

spectrum_id:445976

光谱
生物学性质
1:

cellular:(1):Cytoplasm

2:

biospecimen:(1):Blood

biospecimen:(2):Feces

biospecimen:(3):Urine

3:

4:

[1]:

name:beta-Alanine metabolism

smpdb_id:

kegg_map_id:map00410

[2]:

name:Carnosinuria, carnosinemia

smpdb_id:SMP00493

kegg_map_id:

[3]:

name:GABA-Transaminase Deficiency

smpdb_id:SMP00351

kegg_map_id:

[4]:

name:Ureidopropionase Deficiency

smpdb_id:SMP00492

kegg_map_id:

正常浓度
1:

biospecimen:Blood

concentration_value:0.04 +/- 0.03

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

2:

biospecimen:Urine

concentration_value:0.16 (0.02-0.69)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

3:

biospecimen:Urine

concentration_value:2.55 (0.18-5.85)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Urine

concentration_value:0.015

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

5:

biospecimen:Urine

concentration_value:1.2

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:0.13 +/- 0.13

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

2:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

3:

biospecimen:Urine

concentration_value:0.96 (0.12-2.11)

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Leukemia

疾病参考
1:

name:Perillyl alcohol administration for cancer treatment

omim_id:

[1]:

reference_text:Byun JA, Lee SH, Jung BH, Choi MH, Moon MH, Chung BC: Analysis of polyamines as carbamoyl derivatives in urine and serum by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2008 Jan;22(1):73-80.

pubmed_id:17668437

[2]:

reference_text:Zheng YF, Kong HW, Xiong JH, Lv S, Xu GW: Clinical significance and prognostic value of urinary nucleosides in breast cancer patients. Clin Biochem. 2005 Jan;38(1):24-30.

pubmed_id:15607313

[3]:

reference_text:Cauley JA, Zmuda JM, Danielson ME, Ljung BM, Bauer DC, Cummings SR, Kuller LH: Estrogen metabolites and the risk of breast cancer in older women. Epidemiology. 2003 Nov;14(6):740-4.

pubmed_id:14569192

[4]:

reference_text:Zhang Z, Chen H, Chan KK, Budd T, Ganapathi R: Gas chromatographic-mass spectrometric analysis of perillyl alcohol and metabolites in plasma. J Chromatogr B Biomed Sci Appl. 1999 May 14;728(1):85-95.

pubmed_id:10379660

[5]:

reference_text:Grace PB, Mistry NS, Carter MH, Leathem AJ, Teale P: High throughput quantification of phytoestrogens in human urine and serum using liquid chromatography/tandem mass spectrometry (LC-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):138-46. Epub 2007 Mar 18.

pubmed_id:17403619

[6]:

reference_text:Silva CL, Passos M, Camara JS: Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis. Talanta. 2012 Jan 30;89:360-8. doi: 10.1016/j.talanta.2011.12.041. Epub 2011 Dec 22.

pubmed_id:22284503

[7]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

[8]:

reference_text:Lv W, Yang T: Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC-MS and multivariate statistical analysis. Clin Biochem. 2012 Jan;45(1-2):127-33. doi: 10.1016/j.clinbiochem.2011.10.011. Epub 2011 Oct 26.

pubmed_id:22061338

[9]:

reference_text:Nam H, Chung BC, Kim Y, Lee K, Lee D: Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification. Bioinformatics. 2009 Dec 1;25(23):3151-7. doi: 10.1093/bioinformatics/btp558. Epub 2009 Sep 25.

pubmed_id:19783829

[10]:

reference_text:Woo HM, Kim KM, Choi MH, Jung BH, Lee J, Kong G, Nam SJ, Kim S, Bai SW, Chung BC: Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers. Clin Chim Acta. 2009 Feb;400(1-2):63-9. doi: 10.1016/j.cca.2008.10.014. Epub 2008 Oct 30.

pubmed_id:19010317

2:

name:Colorectal cancer

omim_id:114500

[1]:

reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.

pubmed_id:7482520

[2]:

reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.

pubmed_id:19006102

[3]:

reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.

pubmed_id:23940645

[4]:

reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.

pubmed_id:24424155

[5]:

reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.

pubmed_id:20156336

[6]:

reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.

pubmed_id:19678709

[7]:

reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.

pubmed_id:22148915

[8]:

reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.

pubmed_id:25105552

[9]:

reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.

pubmed_id:21773981

[10]:

reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.

pubmed_id:25037050

[11]:

reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.

pubmed_id:27015276

[12]:

reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.

pubmed_id:27107423

[13]:

reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.

pubmed_id:27275383

[14]:

reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.

pubmed_id:28587349

[15]:

reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984

3:

name:Leukemia

omim_id:

[1]:

reference_text:Lee SH, Suh JW, Chung BC, Kim SO: Polyamine profiles in the urine of patients with leukemia. Cancer Lett. 1998 Jan 9;122(1-2):1-8.

pubmed_id:9464484

[2]:

reference_text:Curtius HC, Wolfensberger M, Redweik U, Leimbacher W, Maibach RA, Isler W: Mass fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in human cerebrospinal fluid. J Chromatogr. 1975 Oct 29;112:523-31.

pubmed_id:1184685

[3]:

reference_text:Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14.

pubmed_id:15911239

[4]:

reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.

pubmed_id:7482520

[5]:

reference_text:Silvennoinen R, Malminiemi K, Malminiemi O, Seppala E, Vilpo J: Pharmacokinetics of chlorambucil in patients with chronic lymphocytic leukaemia: comparison of different days, cycles and doses. Pharmacol Toxicol. 2000 Nov;87(5):223-8.

pubmed_id:11129502

KEGG数据库编号
C00986
DrugBank数据库编号
foodb数据库编号
FDB005274
ChemSpider数据库编号
415
公共化学化合物编号
428
PDB数据库编号
生物利益的化学实体数据库编号
15725
knapsack数据库编号
C00007404
维基百科编号
1,3-Diaminopropane
代谢途径的数据库编号
CPD-313
苯酚资源管理器化合物数据库编号
比格数据库编号
梅林编号
虚拟机身份证编号
fbonto数据库编号
综合参考
Takayanagi, Yasuyuki; Oohinata, Takahiro. Preparation of 1,3-diaminopropane from acrylonitrile and ammonia. Jpn. Kokai Tokkyo Koho (1994), 5 pp.
一般参考
1:

protein_accession:HMDBP00217

name:Spermine synthase

uniprot_id:P52788

gene_name:SMS

protein_type:Enzyme

2:

protein_accession:HMDBP00219

name:Deoxyhypusine synthase

uniprot_id:P49366

gene_name:DHPS

protein_type:Unknown

3:

protein_accession:HMDBP00390

name:Amiloride-sensitive amine oxidase [copper-containing]

uniprot_id:P19801

gene_name:ABP1

protein_type:Unknown

4:

protein_accession:HMDBP00393

name:Membrane primary amine oxidase

uniprot_id:Q16853

gene_name:AOC3

protein_type:Unknown

5:

protein_accession:HMDBP00394

name:Retina-specific copper amine oxidase

uniprot_id:O75106

gene_name:AOC2

protein_type:Unknown

6:

protein_accession:HMDBP00420

name:S-adenosylmethionine decarboxylase proenzyme

uniprot_id:P17707

gene_name:AMD1

protein_type:Unknown

7:

protein_accession:HMDBP01034

name:Ornithine decarboxylase

uniprot_id:P11926

gene_name:ODC1

protein_type:Enzyme

蛋白质结合
1:

reference_text:van den Berg GA, Muskiet FA, Kingma AW, van der Slik W, Halie MR: Simultaneous gas-chromatographic determination of free and acetyl-conjugated polyamines in urine. Clin Chem. 1986 Oct;32(10):1930-7.

pubmed_id:3757213

2:

reference_text:Kim KR, Paik MJ, Kim JH, Dong SW, Jeong DH: Rapid gas chromatographic profiling and screening of biologically active amines. J Pharm Biomed Anal. 1997 Jun;15(9-10):1309-18.

pubmed_id:9226558

3:

reference_text:Bremer HJ, Kohne E: The excretion of diamines in human urine. II. Cadaverine, putrescine, 1,3-diaminopropane, 2,2'-dithiobis(ethylamine) and spermidine in urine of patients with cystinuria and cystinlysinuria. Clin Chim Acta. 1971 May;32(3):407-18.

pubmed_id:5096953

4:

reference_text:Fleisher JH, Russell DH: Estimation of urinary diamines and polyamines by thin-layer chromatography. J Chromatogr. 1975 Jul 16;110(2):335-40.

pubmed_id:1150841

5:

reference_text:Blackburn P, Peterson CM: Thiol-disulfide interchange between cystine and N-2-mercaptoethyl-1, 3-diaminopropane as a potential treatment for cystinuria. Anal Biochem. 1984 Jan;136(1):31-8.

pubmed_id:6324613

6:

reference_text:Aigner-Held R, Campbell RA, Daves GD Jr: Polyamine-pyridoxal Schiff bases in urine. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6652-5.

pubmed_id:293750

7:

reference_text:Somayaji VV, Guay V, Peng Z, Sykes TR, Noujaim AA: Synthesis and evaluation of a new bifunctional chelating agent for the preparation of radioimmunoconjugates. Q J Nucl Med. 1995 Dec;39(4):300-10.

pubmed_id:8624793

8:

reference_text:van den Berg GA, Schaaf JM, Nagel GT, Teelken AW, Muskiet FA: Determination of polyamines and metabolites in cerebrospinal fluid by isotope dilution mass fragmentography, and a clinical application. Clin Chim Acta. 1987 Jun 15;165(2-3):147-54.

pubmed_id:3308180

9:

reference_text:Muskiet FA, van den Berg GA, Kingma AW, Fremouw-Ottevangers DC, Halie MR: Total polyamines and their non-alpha-amino acid metabolites simultaneously determined in urine by capillary gas chromatography, with nitrogen-phosphorus detector; and some clinical applications. Clin Chem. 1984 May;30(5):687-95.

pubmed_id:6713628

10:

reference_text:Lee SH, Suh JW, Chung BC, Kim SO: Polyamine profiles in the urine of patients with leukemia. Cancer Lett. 1998 Jan 9;122(1-2):1-8.

pubmed_id:9464484

11:

reference_text:Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bolling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jonsson JJ, Juty N, Keating S, Nookaew I, Le Novere N, Malys N, Mazein A, Papin JA, Price ND, Selkov E Sr, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, van Beek JH, Weichart D, Goryanin I, Nielsen J, Westerhoff HV, Kell DB, Mendes P, Palsson BO: A community-driven global reconstruction of human metabolism. Nat Biotechnol. 2013 May;31(5):419-25. doi: 10.1038/nbt.2488. Epub 2013 Mar 3.

pubmed_id:23455439

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