创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:45:58 UTC
名称
Uridine diphosphate-N-acetylglucosamine
描述
Uridine diphosphate-N-acetylglucosamine (uridine 5'-diphosphate-GlcNAc, or UDP-Glc-NAc) is an acetylated aminosugar nucleotide. UDP-GlcNAc is the donor substrate for modification of nucleocytoplasmic proteins at serine and threonine residues with N-acetylglucosamine (O-GlcNAc). Nutrient sensing in mammals is done through the hexosamine biosynthetic pathway (HSP), which produces uridine 5'-diphospho-N-acetylglucosamine (UDP-Glc-NAc) as its end product. Mammals respond to nutrient excess by activating O-GlcNAcylation (addition of O-linked N-acetylglucosamine). O-GlcNAc addition (and removal) is key to histone remodeling, transcription, proliferation, apoptosis, and proteasomal degradation. This nutrient-responsive signaling pathway also modulates important cellular pathways, including the insulin signaling cascade in. Alterations in O-GlcNAc metabolism are associated with various human diseases including diabetes mellitus and neurodegeneration. (PMID: 16317114) Due to the chemical makeup of UDP-GlcNAc, it is well positioned to serve as a glucose sensor in that it is a high-energy compound that requires and/or responds to glucose, amino acid, fatty acid and nucleotide metabolism for synthesis. Elevated levels of O-GlcNAc have an effect on insulin-stimulated glucose uptake. (PMID: 12678487).
同义词
1:(2R,3R,4R,5S,6R)-3-(Acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
2:UDP-GlcNAc
3:UDP-N-Acetyl-D-glucosamine
4:UDP-N-Acetylglucosamine
5:URIDINE-diphosphATE-N-acetylglucosamine
6:(2R,3R,4R,5S,6R)-3-(Acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphoric acid (non-preferred name)
7:URIDINE-diphosphoric acid-N-acetylglucosamine
8:Uridine diphosphoric acid-N-acetylglucosamine
9:N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
10:UDP-a-D-N-Acetylglucosamine
11:UDP-Acetyl-D-glucosamine
12:UDP-Acetyl-delta-glucosamine
13:UDP-Acetylglucosamine
14:UDP-alpha-D-N-Acetylglucosamine
15:UDP-alpha-delta-N-Acetylglucosamine
16:UDP-N-Acetyl-delta-glucosamine
17:UDP-N-Acetyl-glucosamine
18:UPPAG
19:Uridine 5'-diphospho-N-acetlyglucosamine
20:Uridine 5'-diphospho-N-acetylglucosamine
21:Uridine diphosphate N-acetyl-D-glucosamine
22:Uridine diphosphate N-acetyl-delta-glucosamine
23:Uridine diphosphate N-acetylglucosamine
24:Uridine diphospho-2-acetamido-2-deoxy-D-glucose
25:Uridine diphospho-2-acetamido-2-deoxy-delta-glucose
26:Uridine diphospho-N-acetyl-D-glucosamine
27:Uridine diphospho-N-acetyl-delta-glucosamine
28:Uridine diphospho-N-acetylglucosamine
29:Uridine diphosphoacetylglucosamine
30:Uridine pyrophosphate 2-acetamido-2-deoxy-a-D-glucopyranosyl ester
31:Uridine pyrophosphate 2-acetamido-2-deoxy-alpha-D-glucopyranosyl ester
32:Uridine pyrophosphate 2-acetamido-2-deoxy-alpha-delta-glucopyranosyl ester
33:Uridine pyrophosphoacetylglucosamine
34:[[3-Acetylamino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxy-phosphoryl]oxy-[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy]phosphinate
35:[[3-Acetylamino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxy-phosphoryl]oxy-[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy]phosphinic acid
36:Acetylglucosamine, UDP
37:Diphosphate N-acetylglucosamine, uridine
38:Diphospho-N-acetylglucosamine, uridine
39:N-Acetylglucosamine, uridine diphosphate
40:Pyrophosphoacetylglucosamine, uridine
41:UDP Acetylglucosamine
42:UDPGNAc
43:Uridine diphosphate N acetylglucosamine
44:Uridine diphospho N acetylglucosamine
45:UDP N-acetyl-alpha-D-glucosamine
46:UDP N-acetyl-α-D-glucosamine
47:UDP-α-D-N-acetylglucosamine
48:Uridine 5'-(2-acetamido-2-deoxy-alpha-D-glucosyl pyrophosphate)
49:Uridine 5'-(2-acetamido-2-deoxy-α-D-glucosyl pyrophosphate)
50:Uridine 5’-(2-acetamido-2-deoxy-α-D-glucosyl pyrophosphate)
化学名称
[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid
传统名称
udp-N-acetyl-α-D-glucosamine
代谢物结构字符串
CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O
inchi标识符
InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1
印记键
LFTYTUAZOPRMMI-CFRASDGPSA-N
分类学
description: belongs to the class of organic compounds known as pyrimidine nucleotide sugars. These are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group.
description:Pyrimidine nucleotide sugars
kingdom:Organic compounds
super_class:Nucleosides, nucleotides, and analogues
class:Pyrimidine nucleotides
sub_class:Pyrimidine nucleotide sugars
molecular_framework:Aromatic heteromonocyclic compounds
1:Acetamides
2:Azacyclic compounds
3:Carbonyl compounds
4:Glycosylamines
5:Heteroaromatic compounds
6:Hydrocarbon derivatives
7:Hydropyrimidines
8:Lactams
9:Monoalkyl phosphates
10:Monosaccharide phosphates
11:N-acyl-alpha-hexosamines
12:Organic oxides
13:Organic pyrophosphates
14:Organonitrogen compounds
15:Organopnictogen compounds
16:Oxacyclic compounds
17:Oxanes
18:Pentose phosphates
19:Primary alcohols
20:Pyrimidine ribonucleoside diphosphates
21:Pyrimidones
22:Secondary alcohols
23:Secondary carboxylic acid amides
24:Tetrahydrofurans
25:Ureas
26:Vinylogous amides
27:Acetamide
28:Alcohol
29:Alkyl phosphate
30:Aromatic heteromonocyclic compound
31:Azacycle
32:Carbonyl group
33:Carboxamide group
34:Carboxylic acid derivative
35:Glycosyl compound
36:Heteroaromatic compound
37:Hydrocarbon derivative
38:Hydropyrimidine
39:Lactam
40:Monoalkyl phosphate
41:Monosaccharide
42:Monosaccharide phosphate
43:N-acyl-alpha-hexosamine
44:N-glycosyl compound
45:Organic nitrogen compound
46:Organic oxide
47:Organic oxygen compound
48:Organic phosphoric acid derivative
49:Organic pyrophosphate
50:Organoheterocyclic compound
51:Organonitrogen compound
52:Organooxygen compound
53:Organopnictogen compound
54:Oxacycle
55:Oxane
56:Pentose phosphate
57:Pentose-5-phosphate
58:Phosphoric acid ester
59:Primary alcohol
60:Pyrimidine
61:Pyrimidine nucleotide sugar
62:Pyrimidine ribonucleoside diphosphate
63:Pyrimidone
64:Secondary alcohol
65:Secondary carboxylic acid amide
66:Tetrahydrofuran
67:Urea
68:Vinylogous amide
69:UDP-amino sugar
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Liver
definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).
parent_id:7727
***level:4
type:child
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Muscle
definition:A fibrous soft tissue with the ability to contract to produce force and motion. (nci).
parent_id:7729
***level:4
type:child
term:Adipose tissue
definition:A specialized form of connective tissue consisting primarily of adipocytes (fat cells), surrounded by a meshwork of collagen fibers. (NCI)
parent_id:7729
***level:4
type:child
synonym:Fat tissue
synonym:Body fat
synonym:Adipose
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Golgi
definition:A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. Note that the Golgi apparatus can be located in various places in the cytoplasm.
parent_id:7730
***level:4
type:child
synonym:Golgi apparatus
synonym:Golgi complex
synonym:Golgi ribbon
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
预测性质
1:
kind:logp
value:-1.41
source:ALOGPS
2:
kind:logs
value:-1.72
source:ALOGPS
3:
kind:solubility
value:11.4 g/L
source:ALOGPS
4:
kind:logp
value:-5.3
source:ChemAxon
5:
kind:pka_strongest_acidic
value:1.74
source:ChemAxon
6:
kind:pka_strongest_basic
value:-3.5
source:ChemAxon
7:
kind:iupac
value:[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid
source:ChemAxon
8:
kind:average_mass
value:607.3537
source:ChemAxon
9:
kind:mono_mass
value:607.081569477
source:ChemAxon
10:
kind:smiles
value:CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O
source:ChemAxon
11:
kind:formula
value:C17H27N3O17P2
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1
source:ChemAxon
13:
kind:inchikey
value:LFTYTUAZOPRMMI-CFRASDGPSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:300.41
source:ChemAxon
15:
kind:refractivity
value:117.56
source:ChemAxon
16:
kind:polarizability
value:50.39
source:ChemAxon
17:
kind:rotatable_bond_count
value:10
source:ChemAxon
18:
kind:acceptor_count
value:14
source:ChemAxon
19:
kind:donor_count
value:9
source:ChemAxon
20:
kind:physiological_charge
value:-2
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:3
source:ChemAxon
23:
kind:bioavailability
value:No
source:ChemAxon
24:
kind:rule_of_five
value:No
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:Yes
source:ChemAxon
1:
type:Specdb::NmrTwoD
spectrum_id:1013
2:
type:Specdb::NmrTwoD
spectrum_id:1257
3:
type:Specdb::CMs
spectrum_id:864
4:
type:Specdb::CMs
spectrum_id:18397
5:
type:Specdb::CMs
spectrum_id:30938
6:
type:Specdb::CMs
spectrum_id:37405
7:
type:Specdb::NmrOneD
spectrum_id:1314
8:
type:Specdb::NmrOneD
spectrum_id:143330
9:
type:Specdb::NmrOneD
spectrum_id:143331
10:
type:Specdb::NmrOneD
spectrum_id:143332
11:
type:Specdb::NmrOneD
spectrum_id:143333
12:
type:Specdb::NmrOneD
spectrum_id:143334
13:
type:Specdb::NmrOneD
spectrum_id:143335
14:
type:Specdb::NmrOneD
spectrum_id:143336
15:
type:Specdb::NmrOneD
spectrum_id:143337
16:
type:Specdb::NmrOneD
spectrum_id:143338
17:
type:Specdb::NmrOneD
spectrum_id:143339
18:
type:Specdb::NmrOneD
spectrum_id:143340
19:
type:Specdb::NmrOneD
spectrum_id:143341
20:
type:Specdb::NmrOneD
spectrum_id:143342
21:
type:Specdb::NmrOneD
spectrum_id:143343
22:
type:Specdb::NmrOneD
spectrum_id:143344
23:
type:Specdb::NmrOneD
spectrum_id:143345
24:
type:Specdb::NmrOneD
spectrum_id:143346
25:
type:Specdb::NmrOneD
spectrum_id:143347
26:
type:Specdb::NmrOneD
spectrum_id:143348
27:
type:Specdb::NmrOneD
spectrum_id:143349
28:
type:Specdb::MsMs
spectrum_id:6243
29:
type:Specdb::MsMs
spectrum_id:6244
30:
type:Specdb::MsMs
spectrum_id:178665
31:
type:Specdb::MsMs
spectrum_id:178666
32:
type:Specdb::MsMs
spectrum_id:178667
33:
type:Specdb::MsMs
spectrum_id:180984
34:
type:Specdb::MsMs
spectrum_id:180985
35:
type:Specdb::MsMs
spectrum_id:180986
36:
type:Specdb::MsMs
spectrum_id:439118
37:
type:Specdb::MsMs
spectrum_id:439119
38:
type:Specdb::MsMs
spectrum_id:2244737
39:
type:Specdb::MsMs
spectrum_id:2245358
40:
type:Specdb::MsMs
spectrum_id:2246880
41:
type:Specdb::MsMs
spectrum_id:2247428
42:
type:Specdb::MsMs
spectrum_id:2248852
43:
type:Specdb::MsMs
spectrum_id:2249518
44:
type:Specdb::MsMs
spectrum_id:2250855
45:
type:Specdb::MsMs
spectrum_id:2251569
46:
type:Specdb::MsMs
spectrum_id:2429329
47:
type:Specdb::MsMs
spectrum_id:2429330
48:
type:Specdb::MsMs
spectrum_id:2429331
49:
type:Specdb::MsMs
spectrum_id:2505533
50:
type:Specdb::MsMs
spectrum_id:2505534
51:
type:Specdb::MsMs
spectrum_id:2505535
生物学性质
1:
cellular:(1):Golgi apparatus
2:
biospecimen:(1):Saliva
3:
tissue:(1):Adipose Tissue
tissue:(2):Liver
tissue:(3):Skeletal Muscle
4:
[1]:
name:Amino Sugar Metabolism
smpdb_id:SMP00045
kegg_map_id:map00520
[2]:
name:G(M2)-Gangliosidosis: Variant B, Tay-sachs disease
smpdb_id:SMP00534
kegg_map_id:
[3]:
name:Salla Disease/Infantile Sialic Acid Storage Disease
smpdb_id:SMP00240
kegg_map_id:
[4]:
name:Sialuria or French Type Sialuria
smpdb_id:SMP00216
kegg_map_id:
[5]:
name:Tay-Sachs Disease
smpdb_id:SMP00390
kegg_map_id:
正常浓度
1:
biospecimen:Saliva
concentration_value:0.110 +/- 0.199
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Saliva
concentration_value:0.272 +/- 0.271
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
代谢途径的数据库编号
UDP-N-ACETYL-D-GLUCOSAMINE
综合参考
Takenouchi, Kenji; Ishige, Kazuya; Midorikawa, Yuichiro; Okuyama, Kiyoshi; Hamamoto, Tomoki; Noguchi, Toshitada. Process for producing uridine diphosphate-N-acetylglucosamine. PCT Int. Appl. (1999), 38 pp.
一般参考
1:
protein_accession:HMDBP00332
name:Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
uniprot_id:Q9Y223
gene_name:GNE
protein_type:Enzyme
2:
protein_accession:HMDBP00940
name:Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
uniprot_id:Q9BRB3
gene_name:PIGQ
protein_type:Enzyme
3:
protein_accession:HMDBP00941
name:Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
uniprot_id:P37287
gene_name:PIGA
protein_type:Enzyme
4:
protein_accession:HMDBP00942
name:Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
uniprot_id:Q14442
gene_name:PIGH
protein_type:Enzyme
5:
protein_accession:HMDBP00943
name:Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
uniprot_id:P57054
gene_name:PIGP
protein_type:Enzyme
6:
protein_accession:HMDBP00944
name:Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
uniprot_id:Q92535
gene_name:PIGC
protein_type:Enzyme
7:
protein_accession:HMDBP01079
name:UDP-N-acetylhexosamine pyrophosphorylase
uniprot_id:Q16222
gene_name:UAP1
protein_type:Enzyme
8:
protein_accession:HMDBP01096
name:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
uniprot_id:Q9H3H5
gene_name:DPAGT1
protein_type:Enzyme
9:
protein_accession:HMDBP01609
name:Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
uniprot_id:Q10469
gene_name:MGAT2
protein_type:Enzyme
10:
protein_accession:HMDBP01699
name:Exostosin-1
uniprot_id:Q16394
gene_name:EXT1
protein_type:Enzyme
11:
protein_accession:HMDBP01700
name:Hyaluronan synthase 1
uniprot_id:Q92839
gene_name:HAS1
protein_type:Unknown
12:
protein_accession:HMDBP01701
name:Exostosin-like 3
uniprot_id:O43909
gene_name:EXTL3
protein_type:Enzyme
13:
protein_accession:HMDBP01702
name:Exostosin-2
uniprot_id:Q93063
gene_name:EXT2
protein_type:Enzyme
14:
protein_accession:HMDBP01703
name:Exostosin-like 1
uniprot_id:Q92935
gene_name:EXTL1
protein_type:Enzyme
15:
protein_accession:HMDBP01704
name:N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
uniprot_id:O43505
gene_name:B3GNT1
protein_type:Enzyme
16:
protein_accession:HMDBP01705
name:Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
uniprot_id:Q09328
gene_name:MGAT5
protein_type:Enzyme
17:
protein_accession:HMDBP01707
name:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
uniprot_id:O15294
gene_name:OGT
protein_type:Enzyme
18:
protein_accession:HMDBP01708
name:Hyaluronan synthase 3
uniprot_id:O00219
gene_name:HAS3
protein_type:Unknown
19:
protein_accession:HMDBP01709
name:Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
uniprot_id:Q09327
gene_name:MGAT3
protein_type:Enzyme
20:
protein_accession:HMDBP01874
name:Hyaluronan synthase 2
uniprot_id:Q92819
gene_name:HAS2
protein_type:Unknown
21:
protein_accession:HMDBP02885
name:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform B
uniprot_id:Q06430
gene_name:GCNT2
protein_type:Enzyme
22:
protein_accession:HMDBP02975
name:UDP-N-acetylglucosamine transporter
uniprot_id:Q9Y2D2
gene_name:SLC35A3
protein_type:Enzyme
23:
protein_accession:HMDBP03225
name:Beta-1,3-N-acetylglucosaminyltransferase bGnT-2
uniprot_id:Q9NY97
gene_name:bGnT-2
protein_type:Enzyme
24:
protein_accession:HMDBP06250
name:Exostosin-like 2
uniprot_id:Q9UBQ6
gene_name:EXTL2
protein_type:Enzyme
25:
protein_accession:HMDBP06336
name:Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
uniprot_id:Q9UM21
gene_name:MGAT4A
protein_type:Enzyme
26:
protein_accession:HMDBP06337
name:Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
uniprot_id:Q9UQ53
gene_name:MGAT4B
protein_type:Enzyme
27:
protein_accession:HMDBP06380
name:Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
uniprot_id:Q9BYG0
gene_name:B3GNT5
protein_type:Enzyme
28:
protein_accession:HMDBP08852
name:Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
uniprot_id:Q8WZA1
gene_name:POMGNT1
protein_type:Unknown
29:
protein_accession:HMDBP09389
name:N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
uniprot_id:Q3T906
gene_name:GNPTAB
protein_type:Enzyme
30:
protein_accession:HMDBP11564
name:UDP-N-acetylglucosamine transferase subunit ALG13 homolog
uniprot_id:Q9NP73
gene_name:ALG13
protein_type:Enzyme
31:
protein_accession:HMDBP11731
name:EGF domain-specific O-linked N-acetylglucosamine transferase
uniprot_id:Q5NDL2
gene_name:EOGT
protein_type:Unknown
32:
protein_accession:HMDBP11742
name:Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
uniprot_id:Q02742
gene_name:GCNT1
protein_type:Unknown
33:
protein_accession:HMDBP11743
name:Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
uniprot_id:O95395
gene_name:GCNT3
protein_type:Unknown
34:
protein_accession:HMDBP11744
name:Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
uniprot_id:Q9P109
gene_name:GCNT4
protein_type:Unknown
35:
protein_accession:HMDBP11751
name:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A
uniprot_id:Q8N0V5
gene_name:GCNT2
protein_type:Unknown
36:
protein_accession:HMDBP11752
name:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C
uniprot_id:Q8NFS9
gene_name:GCNT2
protein_type:Unknown
37:
protein_accession:HMDBP11759
name:Glycosyltransferase-like domain-containing protein 2
uniprot_id:Q8NAT1
gene_name:GTDC2
protein_type:Unknown
38:
protein_accession:HMDBP11826
name:Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
uniprot_id:P26572
gene_name:MGAT1
protein_type:Unknown
39:
protein_accession:HMDBP11827
name:Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
uniprot_id:Q9UBM8
gene_name:MGAT4C
protein_type:Unknown
40:
protein_accession:HMDBP11828
name:Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
uniprot_id:Q3V5L5
gene_name:MGAT5B
protein_type:Unknown
41:
protein_accession:HMDBP11988
name:UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
uniprot_id:Q3KQV9
gene_name:UAP1L1
protein_type:Unknown
蛋白质结合
1:
reference_text:Kobayashi T, Sleeman JE, Coughtrie MW, Burchell B: Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family. Biochem J. 2006 Dec 1;400(2):281-9.
pubmed_id:16965264
2:
reference_text:Kim CH: Increased expression of N-acetylglucosaminyltransferase-V in human hepatoma cells by retinoic acid and 1alpha,25-dihydroxyvitamin D3. Int J Biochem Cell Biol. 2004 Nov;36(11):2307-19.
pubmed_id:15313475
3:
reference_text:Jamieson JC, Kaplan HA, Woloski BM, Hellman M, Ham K: Glycoprotein biosynthesis during the acute-phase response to inflammation. Can J Biochem Cell Biol. 1983 Sep;61(9):1041-8.
pubmed_id:6627106
4:
reference_text:Love DC, Hanover JA: The hexosamine signaling pathway: deciphering the "O-GlcNAc code". Sci STKE. 2005 Nov 29;2005(312):re13.
pubmed_id:16317114
5:
reference_text:Wells L, Vosseller K, Hart GW: A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance. Cell Mol Life Sci. 2003 Feb;60(2):222-8.
pubmed_id:12678487