创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:44:39 UTC
二级访问
HMDB00286
HMDB0060079
HMDB60079
名称
Uridine diphosphate glucose
描述
Uridine diphosphate glucose, also known as UDP-glucose or UDP-alpha-D-glucose, belongs to the class of organic compounds known as pyrimidine nucleotide sugars. These are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group. Uridine diphosphate glucose exists in all living species, ranging from bacteria to plants to humans. Uridine diphosphate glucose is a key intermediate in carbohydrate metabolism. For instance, UDP-glucose is a precursor of glycogen and can be converted into UDP-galactose and UDP-glucuronic acid, which can then be used as substrates by the enzymes that make polysaccharides containing galactose and glucuronic acid. UDP-glucose can also be used as a precursor for the biosynthesis of sucrose, lipopolysaccharides and glycosphingolipids. Within humans, uridine diphosphate glucose participates in a number of enzymatic reactions. In particular, ceramide (D18:1/18:0) and uridine diphosphate glucose can be converted into glucosylceramide (D18:1/18:0) and uridine 5'-diphosphate through the action of the enzyme ceramide glucosyltransferase. In addition, glucosylceramide (D18:1/18:0) and uridine diphosphate glucose can be biosynthesized from lactosylceramide (D18:1/18:0) and uridine 5'-diphosphate through its interaction with the enzyme Beta-1,4-galactosyltransferase 6.
同义词
1:GLUCOSE-uridine-C1,5'-diphosphATE
2:UDP-D-Glucose
3:UDPglucose
4:URIDINE-5'-diphosphATE-glucose
5:UDP-alpha-D-Glucose
6:GLUCOSE-uridine-C1,5'-diphosphoric acid
7:URIDINE-5'-diphosphoric acid-glucose
8:UDP-a-D-Glucose
9:UDP-Α-D-glucose
10:Uridine diphosphoric acid glucose
11:Diphosphate glucose, uridine
12:Diphosphoglucose, uridine
13:Glucose, UDP
14:Glucose, uridine diphosphate
15:UDP Glucose
16:UDPG
17:Uridine diphosphoglucose
18:UDP-GLC
19:UDP-Glucose
20:Uridine 5'-(alpha-D-glucopyranosyl pyrophosphate)
21:Uridine 5'-(α-D-glucopyranosyl pyrophosphate)
22:Uridine 5'-diphosphate glucose
23:Uridine 5'-diphospho-alpha-D-glucose
24:Uridine 5'-diphospho-α-D-glucose
25:Uridine 5'-diphosphoglucose
26:Uridine 5’-(α-D-glucopyranosyl pyrophosphate)
27:Uridine 5’-diphosphate glucose
28:Uridine 5’-diphospho-α-D-glucose
29:Uridine 5’-diphosphoglucose
30:Uridine diphospho-D-glucose
31:Uridine pyrophosphate-glucose
32:Uridine diphosphate glucose
化学名称
[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid
代谢物结构字符串
OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=CC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
inchi标识符
InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
印记键
HSCJRCZFDFQWRP-JZMIEXBBSA-N
分类学
description: belongs to the class of organic compounds known as pyrimidine nucleotide sugars. These are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group.
description:Pyrimidine nucleotide sugars
kingdom:Organic compounds
super_class:Nucleosides, nucleotides, and analogues
class:Pyrimidine nucleotides
sub_class:Pyrimidine nucleotide sugars
molecular_framework:Aromatic heteromonocyclic compounds
1:Azacyclic compounds
2:Glycosylamines
3:Heteroaromatic compounds
4:Hydrocarbon derivatives
5:Hydropyrimidines
6:Lactams
7:Monoalkyl phosphates
8:Monosaccharide phosphates
9:Organic oxides
10:Organic pyrophosphates
11:Organonitrogen compounds
12:Organopnictogen compounds
13:Oxacyclic compounds
14:Oxanes
15:Pentose phosphates
16:Polyols
17:Primary alcohols
18:Pyrimidine ribonucleoside diphosphates
19:Pyrimidones
20:Secondary alcohols
21:Tetrahydrofurans
22:Ureas
23:Vinylogous amides
24:Alcohol
25:Alkyl phosphate
26:Aromatic heteromonocyclic compound
27:Azacycle
28:Glycosyl compound
29:Heteroaromatic compound
30:Hydrocarbon derivative
31:Hydropyrimidine
32:Lactam
33:Monoalkyl phosphate
34:Monosaccharide
35:Monosaccharide phosphate
36:N-glycosyl compound
37:Organic nitrogen compound
38:Organic oxide
39:Organic oxygen compound
40:Organic phosphoric acid derivative
41:Organic pyrophosphate
42:Organoheterocyclic compound
43:Organonitrogen compound
44:Organooxygen compound
45:Organopnictogen compound
46:Oxacycle
47:Oxane
48:Pentose phosphate
49:Pentose-5-phosphate
50:Phosphoric acid ester
51:Polyol
52:Primary alcohol
53:Pyrimidine
54:Pyrimidine nucleotide sugar
55:Pyrimidine ribonucleoside diphosphate
56:Pyrimidone
57:Secondary alcohol
58:Tetrahydrofuran
59:Urea
60:Vinylogous amide
61:UDP-D-glucose
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Animal
definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.
parent_id:7736
***level:4
type:child
synonym:Fauna
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Skeletal muscle
definition:Striated muscles that are under voluntary control of the organism. they are connected at either or both ends to a bone and are utilized for locomotion and other movements. (nci).
parent_id:7729
***level:4
type:child
synonym:Striated muscle
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Liver
definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).
parent_id:7727
***level:4
type:child
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Endoplasmic reticulum
definition:A network of tubular membranes within the cytoplasm of the cell, occurring either with a smooth surface (smooth endoplasmic reticulum) or studded with ribosomes (rough endoplasmic reticulum), involved in the transport of materials. (Infoplease Dictionary via NCI)
parent_id:7730
***level:4
type:child
synonym:Er
term:Golgi
definition:A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. Note that the Golgi apparatus can be located in various places in the cytoplasm.
parent_id:7730
***level:4
type:child
synonym:Golgi apparatus
synonym:Golgi complex
synonym:Golgi ribbon
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
预测性质
1:
kind:logp
value:-1.43
source:ALOGPS
2:
kind:logs
value:-1.58
source:ALOGPS
3:
kind:solubility
value:15 g/L
source:ALOGPS
4:
kind:logp
value:-5
source:ChemAxon
5:
kind:pka_strongest_acidic
value:1.73
source:ChemAxon
6:
kind:pka_strongest_basic
value:-3.6
source:ChemAxon
7:
kind:iupac
value:[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid
source:ChemAxon
8:
kind:average_mass
value:566.3018
source:ChemAxon
9:
kind:mono_mass
value:566.055020376
source:ChemAxon
10:
kind:smiles
value:OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=CC(=O)NC2=O)[C@H](O)[C@@H](O)[C@@H]1O
source:ChemAxon
11:
kind:formula
value:C15H24N2O17P2
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
source:ChemAxon
13:
kind:inchikey
value:HSCJRCZFDFQWRP-JZMIEXBBSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:291.54
source:ChemAxon
15:
kind:refractivity
value:106.46
source:ChemAxon
16:
kind:polarizability
value:45.39
source:ChemAxon
17:
kind:rotatable_bond_count
value:9
source:ChemAxon
18:
kind:acceptor_count
value:14
source:ChemAxon
19:
kind:donor_count
value:9
source:ChemAxon
20:
kind:physiological_charge
value:-2
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:3
source:ChemAxon
23:
kind:bioavailability
value:No
source:ChemAxon
24:
kind:rule_of_five
value:No
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:Yes
source:ChemAxon
1:
type:Specdb::CMs
spectrum_id:36799
2:
type:Specdb::CMs
spectrum_id:48056
3:
type:Specdb::CMs
spectrum_id:282129
4:
type:Specdb::NmrTwoD
spectrum_id:2043
5:
type:Specdb::MsMs
spectrum_id:105438
6:
type:Specdb::MsMs
spectrum_id:105439
7:
type:Specdb::MsMs
spectrum_id:105440
8:
type:Specdb::MsMs
spectrum_id:171927
9:
type:Specdb::MsMs
spectrum_id:171928
10:
type:Specdb::MsMs
spectrum_id:171929
11:
type:Specdb::MsMs
spectrum_id:1448446
12:
type:Specdb::MsMs
spectrum_id:1448447
13:
type:Specdb::MsMs
spectrum_id:1448448
14:
type:Specdb::MsMs
spectrum_id:2227236
15:
type:Specdb::MsMs
spectrum_id:2227489
16:
type:Specdb::MsMs
spectrum_id:2229639
17:
type:Specdb::MsMs
spectrum_id:2229829
18:
type:Specdb::MsMs
spectrum_id:2232087
19:
type:Specdb::MsMs
spectrum_id:2232122
20:
type:Specdb::MsMs
spectrum_id:2407733
21:
type:Specdb::MsMs
spectrum_id:2407734
22:
type:Specdb::MsMs
spectrum_id:2407735
23:
type:Specdb::MsMs
spectrum_id:2531259
24:
type:Specdb::MsMs
spectrum_id:2531260
25:
type:Specdb::MsMs
spectrum_id:2531261
26:
type:Specdb::NmrOneD
spectrum_id:5217
27:
type:Specdb::NmrOneD
spectrum_id:5218
28:
type:Specdb::NmrOneD
spectrum_id:6422
29:
type:Specdb::NmrOneD
spectrum_id:6423
30:
type:Specdb::NmrOneD
spectrum_id:6424
31:
type:Specdb::NmrOneD
spectrum_id:6425
32:
type:Specdb::NmrOneD
spectrum_id:6426
33:
type:Specdb::NmrOneD
spectrum_id:6427
34:
type:Specdb::NmrOneD
spectrum_id:6428
35:
type:Specdb::NmrOneD
spectrum_id:6429
36:
type:Specdb::NmrOneD
spectrum_id:6430
37:
type:Specdb::NmrOneD
spectrum_id:6431
38:
type:Specdb::NmrOneD
spectrum_id:6432
39:
type:Specdb::NmrOneD
spectrum_id:6433
40:
type:Specdb::NmrOneD
spectrum_id:6434
41:
type:Specdb::NmrOneD
spectrum_id:6435
42:
type:Specdb::NmrOneD
spectrum_id:6436
43:
type:Specdb::NmrOneD
spectrum_id:6437
44:
type:Specdb::NmrOneD
spectrum_id:6438
45:
type:Specdb::NmrOneD
spectrum_id:6439
46:
type:Specdb::NmrOneD
spectrum_id:6440
47:
type:Specdb::NmrOneD
spectrum_id:6441
生物学性质
1:
cellular:(1):Endoplasmic reticulum
cellular:(2):Golgi apparatus
2:
biospecimen:(1):Blood
biospecimen:(2):Feces
biospecimen:(3):Urine
3:
tissue:(1):Liver
tissue:(2):Skeletal Muscle
4:
[1]:
name:Congenital disorder of glycosylation CDG-IId
smpdb_id:SMP00579
kegg_map_id:
[2]:
name:Fabry disease
smpdb_id:SMP00525
kegg_map_id:
[3]:
name:Galactose Metabolism
smpdb_id:SMP00043
kegg_map_id:map00052
[4]:
name:Galactosemia
smpdb_id:SMP00182
kegg_map_id:
[5]:
name:Galactosemia II (GALK)
smpdb_id:SMP00495
kegg_map_id:
[6]:
name:Galactosemia III
smpdb_id:SMP00496
kegg_map_id:
[7]:
name:Gaucher Disease
smpdb_id:SMP00349
kegg_map_id:
[8]:
name:Globoid Cell Leukodystrophy
smpdb_id:SMP00348
kegg_map_id:
[9]:
name:GLUT-1 deficiency syndrome
smpdb_id:SMP00580
kegg_map_id:
[10]:
name:Glycogen synthetase deficiency
smpdb_id:SMP00552
kegg_map_id:
[11]:
name:Glycogenosis, Type III. Cori disease, Debrancher glycogenosis
smpdb_id:SMP00553
kegg_map_id:
[12]:
name:Glycogenosis, Type IV. Amylopectinosis, Anderson disease
smpdb_id:SMP00554
kegg_map_id:
[13]:
name:Glycogenosis, Type VI. Hers disease
smpdb_id:SMP00555
kegg_map_id:
[14]:
name:Krabbe disease
smpdb_id:SMP00526
kegg_map_id:
[15]:
name:Lactose Synthesis
smpdb_id:SMP00444
kegg_map_id:
[16]:
name:Metachromatic Leukodystrophy (MLD)
smpdb_id:SMP00347
kegg_map_id:
[17]:
name:Mucopolysaccharidosis VI. Sly syndrome
smpdb_id:SMP00556
kegg_map_id:
[18]:
name:Nucleotide Sugars Metabolism
smpdb_id:SMP00010
kegg_map_id:map00520
[19]:
name:Starch and Sucrose Metabolism
smpdb_id:SMP00058
kegg_map_id:map00500
[20]:
name:Starch and sucrose metabolism
smpdb_id:
kegg_map_id:map00500
[21]:
name:Sucrase-isomaltase deficiency
smpdb_id:SMP00557
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:155.0 +/- 113.0
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
3:
biospecimen:Urine
concentration_value:0.993
concentration_units:umol/mmol creatinine
subject_age:Children (1 - 13 years old)
subject_sex:Not Specified
subject_condition:Normal
异常浓度
1:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Female
patient_information:ankylosing spondylitis
2:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Female
patient_information:rheumatoid arthritis
疾病参考
1:
name:Rheumatoid arthritis
omim_id:180300
[1]:
reference_text:Laitinen O, Seppala E, Nissila M, Vapaatalo H: Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. Clin Rheumatol. 1983 Dec;2(4):401-6.
pubmed_id:6589104
[2]:
reference_text:Chiang EP, Smith DE, Selhub J, Dallal G, Wang YC, Roubenoff R: Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther. 2005;7(6):R1254-62. Epub 2005 Sep 13.
pubmed_id:16277678
[3]:
reference_text:Jensen T, Klarlund M, Hansen M, Jensen KE, Skjodt H, Hyldstrup L: Connective tissue metabolism in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity, bone mineral density, and radiographic outcome. J Rheumatol. 2004 Sep;31(9):1698-708.
pubmed_id:15338487
[4]:
reference_text:Chavis C, Fraissinet L, Chanez P, Thomas E, Bousquet J: A method for the measurement of plasma hydroxyeicosatetraenoic acid levels. Anal Biochem. 1999 Jun 15;271(1):105-8.
pubmed_id:10361015
[5]:
reference_text:Straub RH, Weidler C, Demmel B, Herrmann M, Kees F, Schmidt M, Scholmerich J, Schedel J: Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis. 2004 Aug;63(8):961-8.
pubmed_id:15249323
[6]:
reference_text:Tie-juan ShaoZhi-xing HeZhi-jun XieHai-chang LiMei-jiao WangCheng-ping Wen. Characterization of ankylosing spondylitis and rheumatoid arthritis using 1H NMR-based metabolomics of human fecal extracts. Metabolomics. April 2016, 12:70: https://link.springer.com/article/10.1007/s11306-016-1000-2
维基百科编号
Uridine_diphosphate_glucose
综合参考
Burma, D. P.; Mortimer, D. C. Biosynthesis of uridine diphosphate glucose and sucrose in sugar-beet leaf. Archives of Biochemistry and Biophysics (1956), 62 16-28.
一般参考
1:
protein_accession:HMDBP00119
name:Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
uniprot_id:P22413
gene_name:ENPP1
protein_type:Unknown
2:
protein_accession:HMDBP00194
name:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
uniprot_id:O14638
gene_name:ENPP3
protein_type:Unknown
3:
protein_accession:HMDBP00290
name:Sucrase-isomaltase, intestinal
uniprot_id:P14410
gene_name:SI
protein_type:Enzyme
4:
protein_accession:HMDBP00374
name:Trehalase
uniprot_id:O43280
gene_name:TREH
protein_type:Enzyme
5:
protein_accession:HMDBP00462
name:Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
uniprot_id:O60568
gene_name:PLOD3
protein_type:Unknown
6:
protein_accession:HMDBP00845
name:Ceramide glucosyltransferase
uniprot_id:Q16739
gene_name:UGCG
protein_type:Enzyme
7:
protein_accession:HMDBP00904
name:UDP-glucose 4-epimerase
uniprot_id:Q14376
gene_name:GALE
protein_type:Unknown
8:
protein_accession:HMDBP00907
name:UDP-glucose 6-dehydrogenase
uniprot_id:O60701
gene_name:UGDH
protein_type:Unknown
9:
protein_accession:HMDBP00981
name:Dolichyl-phosphate beta-glucosyltransferase
uniprot_id:Q9Y673
gene_name:ALG5
protein_type:Enzyme
10:
protein_accession:HMDBP01074
name:UTP--glucose-1-phosphate uridylyltransferase
uniprot_id:Q16851
gene_name:UGP2
protein_type:Enzyme
11:
protein_accession:HMDBP01091
name:Glycogen [starch] synthase, liver
uniprot_id:P54840
gene_name:GYS2
protein_type:Enzyme
12:
protein_accession:HMDBP01092
name:Galactose-1-phosphate uridylyltransferase
uniprot_id:P07902
gene_name:GALT
protein_type:Unknown
13:
protein_accession:HMDBP01093
name:Glycogenin-1
uniprot_id:P46976
gene_name:GYG1
protein_type:Unknown
14:
protein_accession:HMDBP01094
name:Glycogen [starch] synthase, muscle
uniprot_id:P13807
gene_name:GYS1
protein_type:Enzyme
15:
protein_accession:HMDBP01095
name:Glycogenin-2
uniprot_id:O15488
gene_name:GYG2
protein_type:Unknown
16:
protein_accession:HMDBP01097
name:Uridine diphosphate glucose pyrophosphatase
uniprot_id:O95848
gene_name:NUDT14
protein_type:Unknown
蛋白质结合
1:
reference_text:Ohdoi C, Nyhan WL, Kuhara T: Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):123-30.
pubmed_id:12829005
2:
reference_text:Tarantino G, Morelli L, Califano C: [Uridine diphosphate glucose (UDPG) in the treatment of hepatic disease from chronic alcohol abuse]. Riv Eur Sci Med Farmacol. 1990 Apr;12(2):109-17.
pubmed_id:2080308
3:
reference_text:Schwartz AL, Rall TW: Hormonal regulation of glycogen metabolism in human fetal liver. II. Regulation of glycogen synthase activity. Diabetes. 1975 Dec;24(12):1113-22.
pubmed_id:811498
4:
reference_text:Hers HG: Mechanisms of blood glucose homeostasis. J Inherit Metab Dis. 1990;13(4):395-410.
pubmed_id:2122108
5:
reference_text:Raila J, Wirth K, Chen F, Buscher U, Dudenhausen JW, Schweigert FJ: Excretion of vitamin A in urine of women during normal pregnancy and pregnancy complications. Ann Nutr Metab. 2004 Sep-Oct;48(5):357-64. Epub 2004 Nov 9.
pubmed_id:15542927
6:
reference_text:Ng WG, Xu YK, Kaufman FR, Donnell GN: Deficit of uridine diphosphate galactose in galactosaemia. J Inherit Metab Dis. 1989;12(3):257-66.
pubmed_id:2515367
7:
reference_text:Marschall HU, Matern H, Wietholtz H, Egestad B, Matern S, Sjovall J: Bile acid N-acetylglucosaminidation. In vivo and in vitro evidence for a selective conjugation reaction of 7 beta-hydroxylated bile acids in humans. J Clin Invest. 1992 Jun;89(6):1981-7.
pubmed_id:1602004
8:
reference_text:Haugen HF, Skrede S: Nucleotide pyrophosphatase and phosphodiesterase I. Demonstration of activity in normal serum, and an increase in cholestatic liver disease. Scand J Gastroenterol. 1976;11(2):121-7.
pubmed_id:4880
9:
reference_text:Reynolds TH 4th, Pak Y, Harris TE, Manchester J, Barrett EJ, Lawrence JC Jr: Effects of insulin and transgenic overexpression of UDP-glucose pyrophosphorylase on UDP-glucose and glycogen accumulation in skeletal muscle fibers. J Biol Chem. 2005 Feb 18;280(7):5510-5. Epub 2004 Dec 13.
pubmed_id:15596435
10:
reference_text:Nielsen JN, Richter EA: Regulation of glycogen synthase in skeletal muscle during exercise. Acta Physiol Scand. 2003 Aug;178(4):309-19.
pubmed_id:12864735
11:
reference_text:Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bolling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jonsson JJ, Juty N, Keating S, Nookaew I, Le Novere N, Malys N, Mazein A, Papin JA, Price ND, Selkov E Sr, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, van Beek JH, Weichart D, Goryanin I, Nielsen J, Westerhoff HV, Kell DB, Mendes P, Palsson BO: A community-driven global reconstruction of human metabolism. Nat Biotechnol. 2013 May;31(5):419-25. doi: 10.1038/nbt.2488. Epub 2013 Mar 3.
pubmed_id:23455439