创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:44:40 UTC
二级访问
HMDB0012194
HMDB00283
HMDB12194
描述
D-Ribose, commonly referred to as simply ribose, is a five-carbon sugar found in all living cells. Ribose is not an essential nutrient because it can be synthesized by almost every tissue in the body from other substances, such as glucose. It is vital for life as a component of DNA, RNA, ATP, ADP, and AMP. In nature, small amounts of ribose can be found in ripe fruits and vegetables. Brewer's yeast, which has a high concentration of RNA, is another rich source of ribose. D-ribose is also a component of many so-called energy drinks and anti-ageing products available on the market today. Ribose is a structural component of ATP, which is the primary energy source for exercising muscle. The adenosine component is an adenine base attached to the five-carbon sugar ribose. ATP provides energy to working muscles by releasing a phosphate group, hence becoming ADP, which in turn may release a phosphate group, then becoming AMP. During intense muscular activity, the total amount of ATP available is quickly depleted. In an effort to correct this imbalance, AMP is broken down in the muscle and secreted from the cell. Once the breakdown products of AMP are released from the cell, the energy potential (TAN pool) of the muscle is reduced and ATP must then be reformed using ribose. Ribose helps restore the level of adenine nucleotides by bypassing the rate-limiting step in the de novo (oxidative pentose phosphate) pathway, which regenerates phosphoribosyl pyrophosphate (PRPP), the essential precursor for ATP. If ribose is not readily available to a cell, glucose may be converted to ribose. Ribose supplementation has been shown to increase the rate of ATP resynthesis following intense exercise. The use of ribose in men with severe coronary artery disease resulted in improved exercise tolerance. Hence, there is interest in the potential of ribose supplements to boost muscular performance in athletic activities (PMID: 17618002, Curr Sports Med Rep. 2007 Jul;6(4):254-7.).
同义词
1:(3R,4S,5R)-5-(Hydroxymethyl)tetrahydrofuran-2,3,4-triol
2:Ribose
3:D-Ribofuranoside
4:D-Ribofuranose
5:Ribofuranoside
6:Ribofuranose
化学名称
(3R,4S,5R)-5-(hydroxymethyl)oxolane-2,3,4-triol
代谢物结构字符串
OC[C@H]1OC(O)[C@H](O)[C@@H]1O
inchi标识符
InChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4-,5?/m1/s1
印记键
HMFHBZSHGGEWLO-SOOFDHNKSA-N
分类学
description: belongs to the class of organic compounds known as pentoses. These are monosaccharides in which the carbohydrate moiety contains five carbon atoms.
description:Pentoses
kingdom:Organic compounds
super_class:Organic oxygen compounds
class:Organooxygen compounds
sub_class:Carbohydrates and carbohydrate conjugates
molecular_framework:Aliphatic heteromonocyclic compounds
1:Hemiacetals
2:Hydrocarbon derivatives
3:Oxacyclic compounds
4:Polyols
5:Primary alcohols
6:Secondary alcohols
7:Tetrahydrofurans
8:Alcohol
9:Aliphatic heteromonocyclic compound
10:Hemiacetal
11:Hydrocarbon derivative
12:Organoheterocyclic compound
13:Oxacycle
14:Pentose monosaccharide
15:Polyol
16:Primary alcohol
17:Secondary alcohol
18:Tetrahydrofuran
19:Aldoses
20:D-ribose
21:ribofuranose
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Fungi
definition:Living eukaryotic organisms belonging to the kingdom fungi. they include mushrooms as well as microbes such as yeast and mold.
parent_id:7736
***level:4
type:parent
synonym:Fungus
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Testicle
definition:Either of the paired male reproductive glands that produce the male germ cells and the male hormones. (nci).
parent_id:7727
***level:4
type:child
synonym:Testes
synonym:Testis
term:Spleen
definition:An abdominal organ that is part of the hematopoietic and immune systems. it is composed of the white pulp and the red pulp and is surrounded by a capsule. (nci).
parent_id:7727
***level:4
type:child
term:Lung
definition:A thoracic organ that has variable lobation and is the primary respiratory organ of mammals.
parent_id:7727
***level:4
type:child
synonym:Lungs
term:Prostate
definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).
parent_id:7727
***level:4
type:child
synonym:Prostate gland
term:Kidney
definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).
parent_id:7727
***level:4
type:child
synonym:Kidneys
term:Pancreas
definition:A digestive organ in the abdomen that has both endocrine and exocrine functions. (nci).
parent_id:7727
***level:4
type:child
term:Endocrine gland
definition:
parent_id:7727
***level:4
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Epidermis
definition:The epithelial portion of the skin (cutis). it consists of the following layers: stratum corneum (horny layer), stratum granulosum (granular layer), stratum spinosum (prickle cell layer), and stratum basale (basal cell layer). (nci).
parent_id:7729
***level:4
type:child
term:Skeletal muscle
definition:Striated muscles that are under voluntary control of the organism. they are connected at either or both ends to a bone and are utilized for locomotion and other movements. (nci).
parent_id:7729
***level:4
type:child
synonym:Striated muscle
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Cerebrospinal fluid
definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).
parent_id:7731
***level:4
type:child
synonym:Csf
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Element
definition:
parent_id:7732
***level:4
type:parent
term:Cell
definition:
parent_id:7732
***level:4
type:parent
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Biological role
definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.
parent_id:7671
*level:2
type:parent
term:Molecular messenger
definition: a chemical substance that is involved in transmission of biochemical signals.
parent_id:7672
**level:3
type:parent
term:Second messenger
definition:A chemical substance that transmit signals from a receptor to a target within a living cell.
parent_id:7677
***level:4
type:child
synonym:Secondary messenger
实验性质
1:
kind:logp
value:-2.32
source:HANSCH,C ET AL. (1995)
2:
kind:melting_point
value:95 °C
source:
预测性质
1:
kind:logp
value:-2.65
source:ALOGPS
2:
kind:logs
value:0.85
source:ALOGPS
3:
kind:solubility
value:1070 g/L
source:ALOGPS
4:
kind:logp
value:-2.3
source:ChemAxon
5:
kind:pka_strongest_acidic
value:11.31
source:ChemAxon
6:
kind:pka_strongest_basic
value:-3
source:ChemAxon
7:
kind:iupac
value:(3R,4S,5R)-5-(hydroxymethyl)oxolane-2,3,4-triol
source:ChemAxon
8:
kind:average_mass
value:150.1299
source:ChemAxon
9:
kind:mono_mass
value:150.05282343
source:ChemAxon
10:
kind:smiles
value:OC[C@H]1OC(O)[C@H](O)[C@@H]1O
source:ChemAxon
11:
kind:formula
value:C5H10O5
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4-,5?/m1/s1
source:ChemAxon
13:
kind:inchikey
value:HMFHBZSHGGEWLO-SOOFDHNKSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:90.15
source:ChemAxon
15:
kind:refractivity
value:29.96
source:ChemAxon
16:
kind:polarizability
value:13.68
source:ChemAxon
17:
kind:rotatable_bond_count
value:1
source:ChemAxon
18:
kind:acceptor_count
value:5
source:ChemAxon
19:
kind:donor_count
value:4
source:ChemAxon
20:
kind:physiological_charge
value:0
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:1
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::NmrTwoD
spectrum_id:1254
2:
type:Specdb::MsMs
spectrum_id:481
3:
type:Specdb::MsMs
spectrum_id:482
4:
type:Specdb::MsMs
spectrum_id:179481
5:
type:Specdb::MsMs
spectrum_id:179482
6:
type:Specdb::MsMs
spectrum_id:179483
7:
type:Specdb::MsMs
spectrum_id:181809
8:
type:Specdb::MsMs
spectrum_id:181810
9:
type:Specdb::MsMs
spectrum_id:181811
10:
type:Specdb::MsMs
spectrum_id:2236312
11:
type:Specdb::MsMs
spectrum_id:2237049
12:
type:Specdb::MsMs
spectrum_id:2238484
13:
type:Specdb::MsMs
spectrum_id:2239120
14:
type:Specdb::MsMs
spectrum_id:2240571
15:
type:Specdb::MsMs
spectrum_id:2241111
16:
type:Specdb::MsMs
spectrum_id:2242643
17:
type:Specdb::MsMs
spectrum_id:2243233
18:
type:Specdb::MsMs
spectrum_id:2251535
19:
type:Specdb::MsMs
spectrum_id:2362058
20:
type:Specdb::MsMs
spectrum_id:2362059
21:
type:Specdb::MsMs
spectrum_id:2362060
22:
type:Specdb::MsMs
spectrum_id:2599739
23:
type:Specdb::MsMs
spectrum_id:2599740
24:
type:Specdb::MsMs
spectrum_id:2599741
25:
type:Specdb::CMs
spectrum_id:512
26:
type:Specdb::CMs
spectrum_id:513
27:
type:Specdb::CMs
spectrum_id:514
28:
type:Specdb::CMs
spectrum_id:515
29:
type:Specdb::CMs
spectrum_id:516
30:
type:Specdb::CMs
spectrum_id:517
31:
type:Specdb::CMs
spectrum_id:518
32:
type:Specdb::CMs
spectrum_id:519
33:
type:Specdb::CMs
spectrum_id:520
34:
type:Specdb::CMs
spectrum_id:3093
35:
type:Specdb::CMs
spectrum_id:30182
36:
type:Specdb::CMs
spectrum_id:30272
37:
type:Specdb::CMs
spectrum_id:30273
38:
type:Specdb::CMs
spectrum_id:30274
39:
type:Specdb::CMs
spectrum_id:30275
40:
type:Specdb::CMs
spectrum_id:30276
41:
type:Specdb::CMs
spectrum_id:30277
42:
type:Specdb::CMs
spectrum_id:30528
43:
type:Specdb::CMs
spectrum_id:30775
44:
type:Specdb::CMs
spectrum_id:37401
45:
type:Specdb::CMs
spectrum_id:168746
46:
type:Specdb::NmrOneD
spectrum_id:1311
47:
type:Specdb::NmrOneD
spectrum_id:143290
48:
type:Specdb::NmrOneD
spectrum_id:143291
49:
type:Specdb::NmrOneD
spectrum_id:143292
50:
type:Specdb::NmrOneD
spectrum_id:143293
51:
type:Specdb::NmrOneD
spectrum_id:143294
52:
type:Specdb::NmrOneD
spectrum_id:143295
53:
type:Specdb::NmrOneD
spectrum_id:143296
54:
type:Specdb::NmrOneD
spectrum_id:143297
55:
type:Specdb::NmrOneD
spectrum_id:143298
56:
type:Specdb::NmrOneD
spectrum_id:143299
57:
type:Specdb::NmrOneD
spectrum_id:143300
58:
type:Specdb::NmrOneD
spectrum_id:143301
59:
type:Specdb::NmrOneD
spectrum_id:143302
60:
type:Specdb::NmrOneD
spectrum_id:143303
61:
type:Specdb::NmrOneD
spectrum_id:143304
62:
type:Specdb::NmrOneD
spectrum_id:143305
63:
type:Specdb::NmrOneD
spectrum_id:143306
64:
type:Specdb::NmrOneD
spectrum_id:143307
65:
type:Specdb::NmrOneD
spectrum_id:143308
66:
type:Specdb::NmrOneD
spectrum_id:143309
生物学性质
1:
cellular:(1):Extracellular
2:
biospecimen:(1):Blood
biospecimen:(2):Cerebrospinal Fluid (CSF)
biospecimen:(3):Feces
biospecimen:(4):Saliva
biospecimen:(5):Urine
3:
tissue:(1):Adrenal Gland
tissue:(2):Epidermis
tissue:(3):Fibroblasts
tissue:(4):Kidney
tissue:(5):Lung
tissue:(6):Neuron
tissue:(7):Pancreas
tissue:(8):Placenta
tissue:(9):Platelet
tissue:(10):Prostate
tissue:(11):Skeletal Muscle
tissue:(12):Spleen
tissue:(13):Testis
4:
[1]:
name:Glucose-6-phosphate dehydrogenase deficiency
smpdb_id:SMP00518
kegg_map_id:
[2]:
name:pentose phosphate pathway
smpdb_id:
kegg_map_id:
[3]:
name:Ribose-5-phosphate isomerase deficiency
smpdb_id:SMP00519
kegg_map_id:
[4]:
name:Transaldolase deficiency
smpdb_id:SMP00520
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:2.3 (0.0-5.0)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:2.5 (0.0 - 5.0)
concentration_units:uM
subject_age:Adolescent (13-18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
5:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
6:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
7:
biospecimen:Feces
concentration_value:1131.0205 +/- 706.721
concentration_units:nmol/g wet feces
subject_age:Not Specified
subject_sex:Not Specified
subject_condition:Normal
8:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
9:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Not Specified
subject_sex:Not Specified
subject_condition:Normal
10:
biospecimen:Feces
concentration_value:1494
concentration_units:nmol/g wet feces
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
11:
biospecimen:Feces
concentration_value:2199
concentration_units:nmol/g wet feces
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
12:
biospecimen:Feces
concentration_value:1184
concentration_units:nmol/g wet feces
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
13:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
14:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
15:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
16:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
17:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
18:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
19:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
20:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
21:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
22:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
23:
biospecimen:Urine
concentration_value:2.5 (0.0 - 5.0)
concentration_units:umol/mmol creatinine
subject_age:Adolescent (13-18 years old)
subject_sex:Both
subject_condition:Normal
24:
biospecimen:Urine
concentration_value:39.757 +/- 18.872
concentration_units:umol/mmol creatinine
subject_age:Children (1 - 13 years old)
subject_sex:Not Specified
subject_condition:Normal
25:
biospecimen:Urine
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
26:
biospecimen:Urine
concentration_value:3.0 (2.6-4.4)
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
27:
biospecimen:Urine
concentration_value:6.35 +/- 4.59
concentration_units:umol/mmol creatinine
subject_age:Infant (0-1 year old)
subject_sex:Both
subject_condition:Normal
异常浓度
1:
biospecimen:Blood
concentration_value:2.4 (0.0-5.0)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Ribose-5-phosphate isomerase deficiency
2:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:90.0 (47.0 - 146.0)
concentration_units:uM
patient_age:Adolescent (13-18 years old)
patient_sex:Both
patient_information:Ribose-5-phosphate isomerase deficiency
3:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
4:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
5:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
6:
biospecimen:Urine
concentration_value:50.0 (5.0 - 102.0)
concentration_units:umol/mmol creatinine
patient_age:Adolescent (13-18 years old)
patient_sex:Both
patient_information:Ribose-5-Phosphate Isomerase Deficiency
7:
biospecimen:Urine
concentration_value:26.892
concentration_units:umol/mmol creatinine
patient_age:Children (1 - 13 years old)
patient_sex:Not Specified
patient_information:Eosinophilic esophagitis
8:
biospecimen:Urine
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Bladder cancer
疾病参考
1:
name:Colorectal cancer
omim_id:114500
[1]:
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[2]:
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[3]:
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[4]:
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[5]:
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[6]:
reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.
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[7]:
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[8]:
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[9]:
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[10]:
reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.
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[11]:
reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.
pubmed_id:27015276
[12]:
reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.
pubmed_id:27107423
[13]:
reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.
pubmed_id:27275383
[14]:
reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.
pubmed_id:28587349
[15]:
reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984
2:
name:Ribose-5-phosphate isomerase deficiency
omim_id:608611
[1]:
reference_text:Huck JH, Verhoeven NM, Struys EA, Salomons GS, Jakobs C, van der Knaap MS: Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy. Am J Hum Genet. 2004 Apr;74(4):745-51. Epub 2004 Feb 25.
pubmed_id:14988808
3:
name:Eosinophilic esophagitis
omim_id:610247
[1]:
reference_text:Mordechai, Hien, and David S. Wishart
pubmed_id:
综合参考
Park, Yong-Cheol; Choi, Jin-Ho; Bennett, George N.; Seo, Jin-Ho. Characterization of D-ribose biosynthesis in Bacillus subtilis JY200 deficient in transketolase gene. Journal of Biotechnology (2006), 121(4), 508-516.
一般参考
1:
protein_accession:HMDBP01088
name:Ribokinase
uniprot_id:Q9H477
gene_name:RBKS
protein_type:Enzyme
蛋白质结合
1:
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pubmed_id:19212411
2:
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7:
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8:
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9:
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11:
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16:
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25:
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26:
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