创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:39:01 UTC
名称
Phosphoribosyl pyrophosphate
描述
Phosphoribosyl pyrophosphate, also known as PRPP or PRib-PP, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. Phosphoribosyl pyrophosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Phosphoribosyl pyrophosphate exists in all living species, ranging from bacteria to humans. Within humans, phosphoribosyl pyrophosphate participates in a number of enzymatic reactions. In particular, guanine and phosphoribosyl pyrophosphate can be biosynthesized from guanosine monophosphate through its interaction with the enzyme adenine phosphoribosyltransferase. In addition, guanine and phosphoribosyl pyrophosphate can be biosynthesized from guanosine monophosphate; which is catalyzed by the enzyme hypoxanthine-guanine phosphoribosyltransferase. In humans, phosphoribosyl pyrophosphate is involved in adenosine deaminase deficiency. Phosphoribosyl pyrophosphate is a pentosephosphate and it is the key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase. It plays a role in transferring phosphate groups in several reactions.
同义词
1:5-Phospho-alpha-D-ribose 1-diphosphate
2:5-Phosphoribosyl 1-pyrophosphate
3:5-Phosphoribosyl diphosphate
4:alpha-D-Ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)
5:ALPHA-PHOSPHORIBOSYLPYROphosphORIC ACID
6:Phosphoribosylpyrophosphate
7:PRib-PP
8:PRPP
9:5-Phospho-a-D-ribose 1-diphosphate
10:5-Phospho-a-D-ribose 1-diphosphoric acid
11:5-Phospho-alpha-D-ribose 1-diphosphoric acid
12:5-Phospho-α-D-ribose 1-diphosphate
13:5-Phospho-α-D-ribose 1-diphosphoric acid
14:5-Phosphoribosyl 1-pyrophosphoric acid
15:5-Phosphoribosyl diphosphoric acid
16:a-D-Ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)
17:a-D-Ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid)
18:alpha-D-Ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid)
19:Α-D-ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)
20:Α-D-ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid)
21:a-PHOSPHORIBOSYLPYROphosphate
22:a-PHOSPHORIBOSYLPYROphosphoric acid
23:alpha-PHOSPHORIBOSYLPYROphosphate
24:Α-phosphoribosylpyrophosphate
25:Α-phosphoribosylpyrophosphoric acid
26:Phosphoribosylpyrophosphoric acid
27:Phosphoribosyl pyrophosphoric acid
28:5-Phospho-a-D-ribose-1-diphosphate
29:5-Phospho-a-D-ribosyl pyrophosphate
30:5-Phospho-alpha-D-ribose-1-diphosphate
31:5-Phospho-alpha-D-ribosyl pyrophosphate
32:5-Phosphoribose 1-pyrophosphate
33:5-Phosphoribosyl 1-diphosphate
34:5-Phosphoribosyl a-1-pyrophosphate
35:5-Phosphoribosyl-1-pyrophosphate
36:5-Phosphorylribose 1-a-diphosphate
37:5-Phosphorylribose 1-alpha-diphosphate
38:5-Phosphorylribose 1-pyrophosphate
39:5-Phosphorylribosyl 1-pyrophosphate
40:a-D-5-(Dihydrogen phosphate) 1-(trihydrogen pyrophosphate) ribofuranose
41:a-D-5-Phosphoribosyl 1-pyrophosphate
42:a-D-Ribofuranose 5-phosphate 1-pyrophosphate
43:a-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)
44:alpha-D-5-(Dihydrogen phosphate) 1-(trihydrogen pyrophosphate) ribofuranose
45:alpha-D-5-Phosphoribosyl 1-pyrophosphate
46:alpha-D-Ribofuranose 5-phosphate 1-pyrophosphate
47:alpha-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)
48:Phosphoribosyl-1-pyrophosphate
49:Phosphoribosyl-pyrophosphate
50:Phosphoribosylpyrophosphorate
51:PP-Ribose-p
52:Pyrophosphate, phosphoribosyl
53:5-Phospho-α-D-ribose-1-diphosphate
54:5-Phospho-α-D-ribosyl pyrophosphate
55:5-Phosphoribosyl alpha-1-pyrophosphate
56:5-Phosphoribosyl pyrophosphate
57:5-Phosphoribosyl α-1-pyrophosphate
58:5-Phosphorylribose 1-α-diphosphate
59:Α-D-5-phosphoribosyl 1-pyrophosphate
60:Phosphoribosyl pyrophosphate
化学名称
[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid
传统名称
phosphoribosylpyrophosphate
代谢物结构字符串
O[C@H]1[C@@H](O)[C@@H](OP(O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O
inchi标识符
InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1
印记键
PQGCEDQWHSBAJP-TXICZTDVSA-N
分类学
description: belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.
description:Pentose phosphates
kingdom:Organic compounds
super_class:Organic oxygen compounds
class:Organooxygen compounds
sub_class:Carbohydrates and carbohydrate conjugates
molecular_framework:Aliphatic heteromonocyclic compounds
1:1,2-diols
2:Hydrocarbon derivatives
3:Monoalkyl phosphates
4:Monosaccharide phosphates
5:Organic oxides
6:Organic pyrophosphates
7:Oxacyclic compounds
8:Secondary alcohols
9:Tetrahydrofurans
10:1,2-diol
11:Alcohol
12:Aliphatic heteromonocyclic compound
13:Alkyl phosphate
14:Hydrocarbon derivative
15:Monoalkyl phosphate
16:Monosaccharide phosphate
17:Organic oxide
18:Organic phosphoric acid derivative
19:Organic pyrophosphate
20:Organoheterocyclic compound
21:Oxacycle
22:Pentose phosphate
23:Pentose-5-phosphate
24:Phosphoric acid ester
25:Secondary alcohol
26:Tetrahydrofuran
27:5-O-phosphono-D-ribofuranosyl diphosphate
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Cell
definition:
parent_id:7732
***level:4
type:parent
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
预测性质
1:
kind:logp
value:-0.74
source:ALOGPS
2:
kind:logs
value:-1.53
source:ALOGPS
3:
kind:solubility
value:11.6 g/L
source:ALOGPS
4:
kind:logp
value:-3
source:ChemAxon
5:
kind:pka_strongest_acidic
value:1.09
source:ChemAxon
6:
kind:pka_strongest_basic
value:-3.7
source:ChemAxon
7:
kind:iupac
value:[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid
source:ChemAxon
8:
kind:average_mass
value:390.0696
source:ChemAxon
9:
kind:mono_mass
value:389.95181466
source:ChemAxon
10:
kind:smiles
value:O[C@H]1[C@@H](O)[C@@H](OP(O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O
source:ChemAxon
11:
kind:formula
value:C5H13O14P3
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1
source:ChemAxon
13:
kind:inchikey
value:PQGCEDQWHSBAJP-TXICZTDVSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:229.74
source:ChemAxon
15:
kind:refractivity
value:62.58
source:ChemAxon
16:
kind:polarizability
value:27.46
source:ChemAxon
17:
kind:rotatable_bond_count
value:7
source:ChemAxon
18:
kind:acceptor_count
value:11
source:ChemAxon
19:
kind:donor_count
value:7
source:ChemAxon
20:
kind:physiological_charge
value:-4
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:1
source:ChemAxon
23:
kind:bioavailability
value:No
source:ChemAxon
24:
kind:rule_of_five
value:No
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
生物学性质
1:
cellular:(1):Cytoplasm
2:
biospecimen:(1):Blood
3:
tissue:(1):Erythrocyte
tissue:(2):Fibroblasts
4:
[1]:
name:2-Hydroxyglutric Aciduria (D And L Form)
smpdb_id:SMP00136
kegg_map_id:
[2]:
name:4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
smpdb_id:SMP00243
kegg_map_id:
[3]:
name:Adenine phosphoribosyltransferase deficiency (APRT)
smpdb_id:SMP00535
kegg_map_id:
[4]:
name:Adenosine Deaminase Deficiency
smpdb_id:SMP00144
kegg_map_id:
[5]:
name:Adenylosuccinate Lyase Deficiency
smpdb_id:SMP00167
kegg_map_id:
[6]:
name:AICA-Ribosiduria
smpdb_id:SMP00168
kegg_map_id:
[7]:
name:Azathioprine Action Pathway
smpdb_id:SMP00427
kegg_map_id:
[8]:
name:Beta Ureidopropionase Deficiency
smpdb_id:SMP00172
kegg_map_id:
[9]:
name:Dihydropyrimidinase Deficiency
smpdb_id:SMP00178
kegg_map_id:
[10]:
name:Glucose-6-phosphate dehydrogenase deficiency
smpdb_id:SMP00518
kegg_map_id:
[11]:
name:Glutamate Metabolism
smpdb_id:SMP00072
kegg_map_id:map00250
[12]:
name:Gout or Kelley-Seegmiller Syndrome
smpdb_id:SMP00365
kegg_map_id:
[13]:
name:Homocarnosinosis
smpdb_id:SMP00385
kegg_map_id:
[14]:
name:Hyperinsulinism-Hyperammonemia Syndrome
smpdb_id:SMP00339
kegg_map_id:
[15]:
name:Lesch-Nyhan Syndrome (LNS)
smpdb_id:SMP00364
kegg_map_id:
[16]:
name:Mercaptopurine Action Pathway
smpdb_id:SMP00428
kegg_map_id:
[17]:
name:Mercaptopurine Metabolism Pathway
smpdb_id:SMP00609
kegg_map_id:
[18]:
name:Mitochondrial DNA depletion syndrome
smpdb_id:SMP00536
kegg_map_id:
[19]:
name:MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
smpdb_id:SMP00202
kegg_map_id:
[20]:
name:Molybdenum Cofactor Deficiency
smpdb_id:SMP00203
kegg_map_id:
[21]:
name:Myoadenylate deaminase deficiency
smpdb_id:SMP00537
kegg_map_id:
[22]:
name:Nicotinate and nicotinamide metabolism
smpdb_id:
kegg_map_id:map00760
[23]:
name:pentose phosphate pathway
smpdb_id:
kegg_map_id:
[24]:
name:Purine metabolism
smpdb_id:
kegg_map_id:map00230
[25]:
name:Purine Nucleoside Phosphorylase Deficiency
smpdb_id:SMP00210
kegg_map_id:
[26]:
name:Pyrimidine metabolism
smpdb_id:
kegg_map_id:map00240
[27]:
name:Ribose-5-phosphate isomerase deficiency
smpdb_id:SMP00519
kegg_map_id:
[28]:
name:Succinic semialdehyde dehydrogenase deficiency
smpdb_id:SMP00567
kegg_map_id:
[29]:
name:Thioguanine Action Pathway
smpdb_id:SMP00430
kegg_map_id:
[30]:
name:Thioguanine Metabolism Pathway
smpdb_id:SMP00647
kegg_map_id:
[31]:
name:Transaldolase deficiency
smpdb_id:SMP00520
kegg_map_id:
[32]:
name:UMP Synthase Deficiency (Orotic Aciduria)
smpdb_id:SMP00219
kegg_map_id:
[33]:
name:Xanthine Dehydrogenase Deficiency (Xanthinuria)
smpdb_id:SMP00220
kegg_map_id:
[34]:
name:Xanthinuria type I
smpdb_id:SMP00512
kegg_map_id:
[35]:
name:Xanthinuria type II
smpdb_id:SMP00513
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:5.72 +/- 0.86
concentration_units:uM
subject_age:Children (1-13 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Blood
concentration_value:4.9 +/- 2.1
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
维基百科编号
Phosphoribosyl pyrophosphate
综合参考
Gross, Akiva; Abril, Obsidiana; Lewis, Jerome M.; Geresh, Shimona; Whitesides, George M. Practical synthesis of 5-phospho-D-ribosyl a-1-pyrophosphate (PRPP): enzymatic routes from ribose 5-phosphate or ribose. Journal of the American Chemical Society (1983), 105(25), 7428-35.
一般参考
1:
protein_accession:HMDBP00331
name:Amidophosphoribosyltransferase
uniprot_id:Q06203
gene_name:PPAT
protein_type:Unknown
2:
protein_accession:HMDBP00337
name:Nicotinate-nucleotide pyrophosphorylase [carboxylating]
uniprot_id:Q15274
gene_name:QPRT
protein_type:Unknown
3:
protein_accession:HMDBP00438
name:Adenine phosphoribosyltransferase
uniprot_id:P07741
gene_name:APRT
protein_type:Enzyme
4:
protein_accession:HMDBP00475
name:Hypoxanthine-guanine phosphoribosyltransferase
uniprot_id:P00492
gene_name:HPRT1
protein_type:Unknown
5:
protein_accession:HMDBP00566
name:Ribose-phosphate pyrophosphokinase 3
uniprot_id:P21108
gene_name:PRPS1L1
protein_type:Unknown
6:
protein_accession:HMDBP00628
name:Ribose-phosphate pyrophosphokinase 1
uniprot_id:P60891
gene_name:PRPS1
protein_type:Unknown
7:
protein_accession:HMDBP00632
name:Ribose-phosphate pyrophosphokinase 2
uniprot_id:P11908
gene_name:PRPS2
protein_type:Unknown
8:
protein_accession:HMDBP01045
name:Uridine 5'-monophosphate synthase
uniprot_id:P11172
gene_name:UMPS
protein_type:Enzyme
9:
protein_accession:HMDBP08864
name:Nicotinamide phosphoribosyltransferase
uniprot_id:P43490
gene_name:NAMPT
protein_type:Unknown
10:
protein_accession:HMDBP08877
name:Nicotinate phosphoribosyltransferase
uniprot_id:Q6XQN6
gene_name:NAPRT1
protein_type:Unknown
11:
protein_accession:HMDBP10684
name:Uracil phosphoribosyltransferase homolog
uniprot_id:Q96BW1
gene_name:UPRT
protein_type:Enzyme
蛋白质结合
1:
reference_text:Snyder FF, Dyer C, Seegmiller JE, Goldblum RM, Mills GC, Schmalstieg FC: Substrate inhibition of adenosine phosphorylation in adenosine deaminase deficiency and adenosine-mediated inhibition of PP-ribose-P dependent nucleotide synthesis in hypoxanthine phosphoribosyltransferase deficient erythrocytes. J Inherit Metab Dis. 1988;11(2):174-83.
pubmed_id:2459496
2:
reference_text:Gordon RB, Keough DT, Emmerson BT: HPRT-deficiency associated with normal PRPP concentration and APRT activity. J Inherit Metab Dis. 1987;10(1):82-8.
pubmed_id:2437388
3:
reference_text:Nishida Y, Akaoka I, Nishizawa T, Maruki M, Maruki K: Synthesis and concentration of 5-phosphoribosyl-1-pyrophosphate in erythrocytes from patients with Down's syndrome. Ann Rheum Dis. 1977 Jun;36(3):261-3.
pubmed_id:141914
4:
reference_text:Ghitis J, Schreiber C, Waxman S: Phosphate-induced phosphoribosylpyrophosphate elevations to assess deranged folate and purine nucleotide metabolism. Proc Soc Exp Biol Med. 1987 Oct;186(1):90-5.
pubmed_id:2442765
5:
reference_text:Yamaoka T, Yano M, Kondo M, Sasaki H, Hino S, Katashima R, Moritani M, Itakura M: Feedback inhibition of amidophosphoribosyltransferase regulates the rate of cell growth via purine nucleotide, DNA, and protein syntheses. J Biol Chem. 2001 Jun 15;276(24):21285-91. Epub 2001 Apr 4.
pubmed_id:11290738
6:
reference_text:Blinov MN, Kamyshentsev MV, Luganova IS, Filanovskaia LI, Filippova VN: [Phosphoribosyl pyrophosphate and its metabolic enzymes in the erythrocytes in certain forms of anemia]. Vopr Med Khim. 1976 Jul-Aug;22(4):456-62.
pubmed_id:194412
7:
reference_text:Micheli V, Taddeo A: [Spectrophotometric assay of 5-phosphoribosyl-1-pyrophosphate synthetase (PRPP) in erythrocyte lysate (author's transl)]. Quad Sclavo Diagn. 1981 Jun;17(2):209-15.
pubmed_id:6267652
8:
reference_text:Sakuma R, Nishina T, Yamanaka H, Kamatani N, Nishioka K, Maeda M, Tsuji A: Phosphoribosylpyrophosphate synthetase in human erythrocytes: assay and kinetic studies using high-performance liquid chromatography. Clin Chim Acta. 1991 Dec 16;203(2-3):143-52.
pubmed_id:1663846
9:
reference_text:Zoref-Shani E, Feinstein S, Frishberg Y, Bromberg Y, Sperling O: Kelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrations. Biochim Biophys Acta. 2000 Feb 21;1500(2):197-203.
pubmed_id:10657589
10:
reference_text:Sperling O, Boer P, Brosh S, Elazar E, Szeinberg A, de Vries A: Normal activity of metabolic pathways involved in the formation and utilization of phosphoribosylpyrophosphate in erythrocytes of patients with primary metabolic gout. Nutr Metab. 1975;18(4):217-23.
pubmed_id:172821
11:
reference_text:Gorbach ZV: [Determination of phosphoribosyl pyrophosphate in the erythrocytes]. Lab Delo. 1977;(12):724-5.
pubmed_id:75318
12:
reference_text:Marcolongo R, Pompucci G, Micheli V: Familial distribution of increased erythrocyte PP-ribose-P levels. Adv Exp Med Biol. 1977;76A:280-6.
pubmed_id:193371
13:
reference_text:Becker MA, Losman MJ, Itkin P, Simkin PA: Gout with superactive phosphoribosylpyrophosphate synthetase due to increased enzyme catalytic rate. J Lab Clin Med. 1982 Apr;99(4):495-511.
pubmed_id:6174658
14:
reference_text:Tax WJ, Veerkamp JH: A simple and sensitive method for estimating the concentration and synthesis of 5-phosphoribosyl 1-pyrophosphate in red blood cells. Clin Chim Acta. 1977 Jul 15;78(2):209-16.
pubmed_id:195752
15:
reference_text:MacDermot KD, Allsop J, Watts RW: The rate of purine synthesis de nova in blood mononuclear cells in vitro from patients with familial hyperuricaemic nephropathy. Clin Sci (Lond). 1984 Aug;67(2):249-58.
pubmed_id:6744792
16:
reference_text:Emmerson BT, Gordon RB, Thompson L: Adenine phosphoribosyltransferase deficiency: its inheritance and occurrence in a female with gout and renal disease. Aust N Z J Med. 1975 Oct;5(5):440-6.
pubmed_id:1061547
17:
reference_text:Zerez CR, Lachant NA, Tanaka KR: Decreased erythrocyte phosphoribosylpyrophosphate synthetase activity and impaired formation in thalassemia minor: a mechanism for decreased adenine nucleotide content. J Lab Clin Med. 1989 Jul;114(1):43-50.
pubmed_id:2544652
18:
reference_text:Rylance HJ, Wallace RC, Nuki G: A method for the determination of 5-phosphoribosyl 1-pyrophosphate concentrations in erythrocytes using high-performance liquid chromatography. Anal Biochem. 1987 Feb 1;160(2):337-41.
pubmed_id:2437821
19:
reference_text:Kane MA, Roth E, Raptis G, Schreiber C, Waxman S: Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells. Cancer Res. 1987 Dec 15;47(24 Pt 1):6444-50.
pubmed_id:2445472
20:
reference_text:Lachant NA, Zerez CR, Tanaka KR: Pyrimidine nucleotides impair phosphoribosylpyrophosphate (PRPP) synthetase subunit aggregation by sequestering magnesium. A mechanism for the decreased PRPP synthetase activity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency. Biochim Biophys Acta. 1989 Jan 19;994(1):81-8.
pubmed_id:2535789