创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:46:10 UTC
描述
Thymidine, also known as deoxythymidine or deoxyribosylthymine or thymine deoxyriboside, is a pyrimidine deoxynucleoside. It consists of the nucleobase thymine attached to deoxyribose through a beta N- glycosidic bond. Thymidine also belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. Pyrimidine 2'-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2. Deoxythymidine (or thymidine) is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. Therefore, thymidine is essential to all life. Indeed, thymidine exists in all living species, ranging from bacteria to plants to humans. Within humans, thymidine participates in a number of enzymatic reactions. In particular, thymidine can be biosynthesized from 5-thymidylic acid through its interaction with the enzyme cytosolic purine 5'-nucleotidase. In addition, thymidine can be converted into 5-thymidylic acid; which is catalyzed by the enzyme thymidine kinase. Deoxythymidine can be phosphorylated with one, two or three phosphoric acid groups, creating dTMP (deoxythymidine monophosphate), dTDP, or dTTP (for the di- and tri- phosphates, respectively). dTMP can be incorporated into DNA via DNA polymerases. In cell biology, thymidine can be used to synchronize the cells in S phase. Derivatives of thymidine are used in a number of drugs, including Azidothymidine (AZT), which is used in the treatment of HIV infection. AZT inhibits the process of reverse transcription in the human immunodeficiency virus.
同义词
1:1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
2:2'-Deoxy-5-methyluridine
3:2'-Deoxythymidine
4:2'-Thymidine
5:5-Methyl-2'-deoxyuridine
6:Deoxythymidine
7:DTHD
8:T
9:Thymine 2'-deoxyriboside
10:1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
11:1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
12:1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
13:1-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
14:1-[4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
15:2'-Deoxy-5-methyl-uridine
16:5-Methyldeoxyuridine
17:Deoxyribothymidine
18:DT
19:DThyd
20:Thymidin
21:Thymine 2-desoxyriboside
22:Thymine deoxyriboside
23:Thymine-1 2-deoxy-b-D-ribofuranoside
24:Thymine-1 2-deoxy-beta-delta-ribofuranoside
25:2' Deoxythymidine
化学名称
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
代谢物结构字符串
CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O
inchi标识符
InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1
印记键
IQFYYKKMVGJFEH-XLPZGREQSA-N
分类学
description: belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. Pyrimidine 2'-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2.
description:Pyrimidine 2'-deoxyribonucleosides
kingdom:Organic compounds
super_class:Nucleosides, nucleotides, and analogues
class:Pyrimidine nucleosides
sub_class:Pyrimidine 2'-deoxyribonucleosides
molecular_framework:Aromatic heteromonocyclic compounds
1:Azacyclic compounds
2:Heteroaromatic compounds
3:Hydrocarbon derivatives
4:Hydropyrimidines
5:Hydroxypyrimidines
6:Organic oxides
7:Organonitrogen compounds
8:Organopnictogen compounds
9:Oxacyclic compounds
10:Primary alcohols
11:Pyrimidones
12:Secondary alcohols
13:Tetrahydrofurans
14:Alcohol
15:Aromatic heteromonocyclic compound
16:Azacycle
17:Heteroaromatic compound
18:Hydrocarbon derivative
19:Hydropyrimidine
20:Hydroxypyrimidine
21:Organic nitrogen compound
22:Organic oxide
23:Organic oxygen compound
24:Organoheterocyclic compound
25:Organonitrogen compound
26:Organooxygen compound
27:Organopnictogen compound
28:Oxacycle
29:Primary alcohol
30:Pyrimidine
31:Pyrimidine 2'-deoxyribonucleoside
32:Pyrimidone
33:Secondary alcohol
34:Tetrahydrofuran
35:Deoxyribonucleosides
36:pyrimidine 2'-deoxyribonucleoside
本体论
term:Physiological effect
definition:The effect on an organism physiology, resulting from its exposure to a chemical.
parent_id:
level:1
type:parent
term:Health effect
definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.
parent_id:7693
*level:2
type:parent
term:Observation
definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.
parent_id:7694
**level:3
type:parent
term:Attachment loss
definition:
parent_id:7717
***level:4
type:child
term:Missing teeth
definition:
parent_id:7717
***level:4
type:child
term:Periodontal Probing Depth
definition:
parent_id:7717
***level:4
type:child
term:Health condition
definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.
parent_id:7694
**level:3
type:parent
term:Degenerative disc disease
definition:A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc. (do).
parent_id:7695
***level:4
type:child
synonym:Ddd
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Testicle
definition:Either of the paired male reproductive glands that produce the male germ cells and the male hormones. (nci).
parent_id:7727
***level:4
type:child
synonym:Testes
synonym:Testis
term:Spleen
definition:An abdominal organ that is part of the hematopoietic and immune systems. it is composed of the white pulp and the red pulp and is surrounded by a capsule. (nci).
parent_id:7727
***level:4
type:child
term:Bladder
definition:The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra. (nci).
parent_id:7727
***level:4
type:child
term:Skin
definition:An organ that constitutes the external surface of the body. it consists of the epidermis, dermis, and skin appendages. (nci).
parent_id:7727
***level:4
type:child
term:Intestine
definition:The portion of the gastrointestinal tract that includes the small and large intestines.
parent_id:7727
***level:4
type:child
term:Prostate
definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).
parent_id:7727
***level:4
type:child
synonym:Prostate gland
term:Kidney
definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).
parent_id:7727
***level:4
type:child
synonym:Kidneys
term:Pancreas
definition:A digestive organ in the abdomen that has both endocrine and exocrine functions. (nci).
parent_id:7727
***level:4
type:child
term:Endocrine gland
definition:
parent_id:7727
***level:4
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Adipose tissue
definition:A specialized form of connective tissue consisting primarily of adipocytes (fat cells), surrounded by a meshwork of collagen fibers. (NCI)
parent_id:7729
***level:4
type:child
synonym:Fat tissue
synonym:Body fat
synonym:Adipose
term:Skeletal muscle
definition:Striated muscles that are under voluntary control of the organism. they are connected at either or both ends to a bone and are utilized for locomotion and other movements. (nci).
parent_id:7729
***level:4
type:child
synonym:Striated muscle
term:Muscle
definition:A fibrous soft tissue with the ability to contract to produce force and motion. (nci).
parent_id:7729
***level:4
type:child
term:Epidermis
definition:The epithelial portion of the skin (cutis). it consists of the following layers: stratum corneum (horny layer), stratum granulosum (granular layer), stratum spinosum (prickle cell layer), and stratum basale (basal cell layer). (nci).
parent_id:7729
***level:4
type:child
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Cerebrospinal fluid
definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).
parent_id:7731
***level:4
type:child
synonym:Csf
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Element
definition:
parent_id:7732
***level:4
type:parent
term:Cell
definition:
parent_id:7732
***level:4
type:parent
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Mitochondria
definition:
parent_id:7730
***level:4
type:child
term:Lysosome
definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).
parent_id:7730
***level:4
type:child
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Biological role
definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.
parent_id:7671
*level:2
type:parent
term:Metabolite
definition:A chemical substance produced during metabolism process, as an intermediate or end-product.
parent_id:7672
**level:3
type:child
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
实验性质
1:
kind:water_solubility
value:73.5 mg/mL
source:
2:
kind:logp
value:-0.93
source:SANGSTER (1993)
预测性质
1:
kind:logp
value:-1.32
source:ALOGPS
2:
kind:logs
value:-0.56
source:ALOGPS
3:
kind:solubility
value:66.8 g/L
source:ALOGPS
4:
kind:logp
value:-1.1
source:ChemAxon
5:
kind:pka_strongest_acidic
value:9.96
source:ChemAxon
6:
kind:pka_strongest_basic
value:-3
source:ChemAxon
7:
kind:iupac
value:1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
source:ChemAxon
8:
kind:average_mass
value:242.2286
source:ChemAxon
9:
kind:mono_mass
value:242.090271568
source:ChemAxon
10:
kind:smiles
value:CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O
source:ChemAxon
11:
kind:formula
value:C10H14N2O5
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1
source:ChemAxon
13:
kind:inchikey
value:IQFYYKKMVGJFEH-XLPZGREQSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:99.1
source:ChemAxon
15:
kind:refractivity
value:55.41
source:ChemAxon
16:
kind:polarizability
value:23.06
source:ChemAxon
17:
kind:rotatable_bond_count
value:2
source:ChemAxon
18:
kind:acceptor_count
value:5
source:ChemAxon
19:
kind:donor_count
value:3
source:ChemAxon
20:
kind:physiological_charge
value:0
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:2
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::EiMs
spectrum_id:1979
2:
type:Specdb::NmrTwoD
spectrum_id:1012
3:
type:Specdb::NmrTwoD
spectrum_id:1252
4:
type:Specdb::CMs
spectrum_id:1960
5:
type:Specdb::CMs
spectrum_id:1993
6:
type:Specdb::CMs
spectrum_id:2811
7:
type:Specdb::CMs
spectrum_id:31112
8:
type:Specdb::CMs
spectrum_id:31113
9:
type:Specdb::CMs
spectrum_id:32286
10:
type:Specdb::CMs
spectrum_id:32329
11:
type:Specdb::CMs
spectrum_id:32330
12:
type:Specdb::CMs
spectrum_id:37397
13:
type:Specdb::CMs
spectrum_id:157927
14:
type:Specdb::NmrOneD
spectrum_id:1309
15:
type:Specdb::NmrOneD
spectrum_id:4904
16:
type:Specdb::NmrOneD
spectrum_id:4905
17:
type:Specdb::NmrOneD
spectrum_id:6382
18:
type:Specdb::NmrOneD
spectrum_id:6383
19:
type:Specdb::NmrOneD
spectrum_id:6384
20:
type:Specdb::NmrOneD
spectrum_id:6385
21:
type:Specdb::NmrOneD
spectrum_id:6386
22:
type:Specdb::NmrOneD
spectrum_id:6387
23:
type:Specdb::NmrOneD
spectrum_id:6388
24:
type:Specdb::NmrOneD
spectrum_id:6389
25:
type:Specdb::NmrOneD
spectrum_id:6390
26:
type:Specdb::NmrOneD
spectrum_id:6391
27:
type:Specdb::NmrOneD
spectrum_id:6392
28:
type:Specdb::NmrOneD
spectrum_id:6393
29:
type:Specdb::NmrOneD
spectrum_id:6394
30:
type:Specdb::NmrOneD
spectrum_id:6395
31:
type:Specdb::NmrOneD
spectrum_id:6396
32:
type:Specdb::NmrOneD
spectrum_id:6397
33:
type:Specdb::NmrOneD
spectrum_id:6398
34:
type:Specdb::NmrOneD
spectrum_id:6399
35:
type:Specdb::NmrOneD
spectrum_id:6400
36:
type:Specdb::NmrOneD
spectrum_id:6401
37:
type:Specdb::MsMs
spectrum_id:478
38:
type:Specdb::MsMs
spectrum_id:479
39:
type:Specdb::MsMs
spectrum_id:480
40:
type:Specdb::MsMs
spectrum_id:3904
41:
type:Specdb::MsMs
spectrum_id:3905
42:
type:Specdb::MsMs
spectrum_id:3906
43:
type:Specdb::MsMs
spectrum_id:3907
44:
type:Specdb::MsMs
spectrum_id:3908
45:
type:Specdb::MsMs
spectrum_id:3909
46:
type:Specdb::MsMs
spectrum_id:3910
47:
type:Specdb::MsMs
spectrum_id:3911
48:
type:Specdb::MsMs
spectrum_id:3912
49:
type:Specdb::MsMs
spectrum_id:3913
50:
type:Specdb::MsMs
spectrum_id:3914
51:
type:Specdb::MsMs
spectrum_id:3915
52:
type:Specdb::MsMs
spectrum_id:3916
53:
type:Specdb::MsMs
spectrum_id:3917
54:
type:Specdb::MsMs
spectrum_id:178890
55:
type:Specdb::MsMs
spectrum_id:178891
56:
type:Specdb::MsMs
spectrum_id:178892
57:
type:Specdb::MsMs
spectrum_id:181215
58:
type:Specdb::MsMs
spectrum_id:181216
59:
type:Specdb::MsMs
spectrum_id:181217
60:
type:Specdb::MsMs
spectrum_id:438495
61:
type:Specdb::MsMs
spectrum_id:438496
生物学性质
1:
cellular:(1):Extracellular
cellular:(2):Lysosome
cellular:(3):Mitochondria
2:
biospecimen:(1):Amniotic Fluid
biospecimen:(2):Blood
biospecimen:(3):Cerebrospinal Fluid (CSF)
biospecimen:(4):Feces
biospecimen:(5):Saliva
biospecimen:(6):Urine
3:
tissue:(1):Adipose Tissue
tissue:(2):Adrenal Gland
tissue:(3):Bladder
tissue:(4):Epidermis
tissue:(5):Fibroblasts
tissue:(6):Intestine
tissue:(7):Kidney
tissue:(8):Neuron
tissue:(9):Pancreas
tissue:(10):Placenta
tissue:(11):Platelet
tissue:(12):Prostate
tissue:(13):Skeletal Muscle
tissue:(14):Spleen
tissue:(15):Testis
tissue:(16):Thyroid Gland
4:
[1]:
name:Beta Ureidopropionase Deficiency
smpdb_id:SMP00172
kegg_map_id:
[2]:
name:Dihydropyrimidinase Deficiency
smpdb_id:SMP00178
kegg_map_id:
[3]:
name:MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
smpdb_id:SMP00202
kegg_map_id:
[4]:
name:Pyrimidine metabolism
smpdb_id:
kegg_map_id:map00240
[5]:
name:UMP Synthase Deficiency (Orotic Aciduria)
smpdb_id:SMP00219
kegg_map_id:
正常浓度
1:
biospecimen:Amniotic Fluid
concentration_value:1.52 +/- 1.21
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
2:
biospecimen:Blood
concentration_value:0.2
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Blood
concentration_value:0.21 +/- 0.13
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Blood
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
5:
biospecimen:Blood
concentration_value:<0.1
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
6:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
7:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
8:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
9:
biospecimen:Saliva
concentration_value:0.221 +/- 0.800
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
10:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
11:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
12:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
13:
biospecimen:Saliva
concentration_value:2.52 +/- 0.579
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
14:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
15:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
16:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
17:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
18:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
19:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
20:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
21:
biospecimen:Urine
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
22:
biospecimen:Urine
concentration_value:0-3
concentration_units:umol/mmol creatinine
subject_age:Children (1 - 18 years old)
subject_sex:Both
subject_condition:Normal
23:
biospecimen:Urine
concentration_value:2.113 +/- 0.875
concentration_units:umol/mmol creatinine
subject_age:Children (1 - 13 years old)
subject_sex:Not Specified
subject_condition:Normal
24:
biospecimen:Urine
concentration_value:2.46 +/- 2.03
concentration_units:umol/mmol creatinine
subject_age:Children (1-13 years old)
subject_sex:Both
subject_condition:Normal
25:
biospecimen:Urine
concentration_value:1.38 +/- 1.02
concentration_units:umol/mmol creatinine
subject_age:Adolescent (13-18 years old)
subject_sex:Both
subject_condition:Normal
26:
biospecimen:Urine
concentration_value:6.87 +/- 4.86
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
27:
biospecimen:Urine
concentration_value:2.2 (0.7-3.9)
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
28:
biospecimen:Urine
concentration_value:<0.1
concentration_units:umol/mmol creatinine
subject_age:Infant (0-1 year old)
subject_sex:Both
subject_condition:Normal
29:
biospecimen:Urine
concentration_value:<5
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
异常浓度
1:
biospecimen:Blood
concentration_value:0.31 +/- 0.09
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Canavan disease
2:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.06 (0.0-0.120
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Degenerative disc disease
3:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
4:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
5:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
6:
biospecimen:Saliva
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Male
patient_information:Attachment loss
7:
biospecimen:Saliva
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Male
patient_information:Missing teeth
8:
biospecimen:Saliva
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Male
patient_information:Periodontal Probing Depth
9:
biospecimen:Urine
concentration_value:3.431 +/- 0.539
concentration_units:umol/mmol creatinine
patient_age:Children (1 - 13 years old)
patient_sex:Not Specified
patient_information:Eosinophilic esophagitis
10:
biospecimen:Urine
concentration_value:4.58 +/- 4.58
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Canavan disease
11:
biospecimen:Urine
concentration_value:29
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Male
patient_information:Thymidine phosphorylase deficiency
疾病参考
1:
name:Canavan disease
omim_id:271900
[1]:
reference_text:Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51.
pubmed_id:7729054
[2]:
reference_text:Rothstein JD, Tsai G, Kuncl RW, Clawson L, Cornblath DR, Drachman DB, Pestronk A, Stauch BL, Coyle JT: Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol. 1990 Jul;28(1):18-25.
pubmed_id:2375630
[3]:
reference_text:Burlina AP, Ferrari V, Divry P, Gradowska W, Jakobs C, Bennett MJ, Sewell AC, Dionisi-Vici C, Burlina AB: N-acetylaspartylglutamate in Canavan disease: an adverse effector? Eur J Pediatr. 1999 May;158(5):406-9.
pubmed_id:10333125
[4]:
reference_text:Tavazzi B, Lazzarino G, Leone P, Amorini AM, Bellia F, Janson CG, Di Pietro V, Ceccarelli L, Donzelli S, Francis JS, Giardina B: Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism. Clin Biochem. 2005 Nov;38(11):997-1008. Epub 2005 Sep 1.
pubmed_id:16139832
[5]:
reference_text:Burlina AP, Ferrari V, Burlina AB, Ermani M, Boespflug-Tanguy O, Bertini E: N-acetylaspartylglutamate (NAAG) in Pelizaeus-Merzbacher disease. Adv Exp Med Biol. 2006;576:353-9; discussion 361-3. doi: 10.1007/0-387-30172-0_26.
pubmed_id:16802726
[6]:
reference_text:Matalon R, Michals K, Sebesta D, Deanching M, Gashkoff P, Casanova J: Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. Am J Med Genet. 1988 Feb;29(2):463-71. doi: 10.1002/ajmg.1320290234.
pubmed_id:3354621
[7]:
reference_text:Matalon R, Kaul R, Casanova J, Michals K, Johnson A, Rapin I, Gashkoff P, Deanching M: SSIEM Award. Aspartoacylase deficiency: the enzyme defect in Canavan disease. J Inherit Metab Dis. 1989;12 Suppl 2:329-31.
pubmed_id:2512436
2:
name:Degenerative disc disease
omim_id:
[1]:
reference_text:Eells JT, Spector R: Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma. Neurochem Res. 1983 Nov;8(11):1451-7.
pubmed_id:6656991
3:
name:Colorectal cancer
omim_id:114500
[1]:
reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.
pubmed_id:7482520
[2]:
reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.
pubmed_id:19006102
[3]:
reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.
pubmed_id:23940645
[4]:
reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.
pubmed_id:24424155
[5]:
reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.
pubmed_id:20156336
[6]:
reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.
pubmed_id:19678709
[7]:
reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.
pubmed_id:22148915
[8]:
reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.
pubmed_id:25105552
[9]:
reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.
pubmed_id:21773981
[10]:
reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.
pubmed_id:25037050
[11]:
reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.
pubmed_id:27015276
[12]:
reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.
pubmed_id:27107423
[13]:
reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.
pubmed_id:27275383
[14]:
reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.
pubmed_id:28587349
[15]:
reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984
4:
name:Attachment loss
omim_id:
[1]:
reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.
pubmed_id:31026179
5:
name:Missing teeth
omim_id:
[1]:
reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.
pubmed_id:31026179
6:
name:Periodontal Probing Depth
omim_id:
[1]:
reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.
pubmed_id:31026179
7:
name:Eosinophilic esophagitis
omim_id:610247
[1]:
reference_text:Mordechai, Hien, and David S. Wishart
pubmed_id:
8:
name:Thymidine phosphorylase deficiency
omim_id:603041
[1]:
reference_text:Bakker JA, Schlesser P, Smeets HJ, Francois B, Bierau J: Biochemical abnormalities in a patient with thymidine phosphorylase deficiency with fatal outcome. J Inherit Metab Dis. 2010 Dec;33 Suppl 3:S139-43. doi: 10.1007/s10545-010-9049-y. Epub 2010 Feb 12.
pubmed_id:20151198
综合参考
Herdewijn, P.; Kerremans, L.; Wigerinck, P.; Vandendriessche, F.; Van Aerschot, A. Synthesis of thymidine from 5-iodo-2'-deoxyuridine. Tetrahedron Letters (1991), 32(34), 4397-400.
一般参考
1:
protein_accession:HMDBP00001
name:5'-nucleotidase
uniprot_id:P21589
gene_name:NT5E
protein_type:Unknown
2:
protein_accession:HMDBP00004
name:Cytosolic 5'-nucleotidase 1B
uniprot_id:Q96P26
gene_name:NT5C1B
protein_type:Unknown
3:
protein_accession:HMDBP00005
name:Cytosolic 5'-nucleotidase 1A
uniprot_id:Q9BXI3
gene_name:NT5C1A
protein_type:Unknown
4:
protein_accession:HMDBP00006
name:5'(3')-deoxyribonucleotidase, cytosolic type
uniprot_id:Q8TCD5
gene_name:NT5C
protein_type:Unknown
5:
protein_accession:HMDBP00008
name:5'(3')-deoxyribonucleotidase, mitochondrial
uniprot_id:Q9NPB1
gene_name:NT5M
protein_type:Unknown
6:
protein_accession:HMDBP02574
name:Solute carrier family 22 member 1
uniprot_id:O15245
gene_name:SLC22A1
protein_type:Transporter
7:
protein_accession:HMDBP03189
name:Cytosolic 5'-nucleotidase 3
uniprot_id:Q9H0P0
gene_name:NT5C3
protein_type:Enzyme
8:
protein_accession:HMDBP03750
name:Cytosolic purine 5'-nucleotidase
uniprot_id:P49902
gene_name:NT5C2
protein_type:Unknown
9:
protein_accession:HMDBP03808
name:Solute carrier family 28 member 3
uniprot_id:Q9HAS3
gene_name:SLC28A3
protein_type:Transporter
10:
protein_accession:HMDBP03814
name:Thymidine kinase, cytosolic
uniprot_id:P04183
gene_name:TK1
protein_type:Enzyme
11:
protein_accession:HMDBP03815
name:Thymidine kinase 2, mitochondrial
uniprot_id:O00142
gene_name:TK2
protein_type:Enzyme
12:
protein_accession:HMDBP03818
name:Thymidine phosphorylase
uniprot_id:P19971
gene_name:TYMP
protein_type:Enzyme
13:
protein_accession:HMDBP09241
name:Thymidine kinase
uniprot_id:Q8IZR3
gene_name:
protein_type:Enzyme
蛋白质结合
1:
reference_text:Eells JT, Spector R: Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma. Neurochem Res. 1983 Nov;8(11):1451-7.
pubmed_id:6656991
2:
reference_text:Zhao R, Zhang S, Hanscom M, Chattopadhyay S, Goldman ID: Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. Clin Cancer Res. 2005 Feb 1;11(3):1294-301.
pubmed_id:15709201
3:
reference_text:Robins HI, Tutsch K, Katschinski DM, Jacobson E, Mehta M, Olsen M, Cohen JD, Tiggelaar CL, Arzoomanian RZ, Alberti D, Feierabend C, Wilding G: Phase I trial of intravenous thymidine and carboplatin in patients with advanced cancer. J Clin Oncol. 1999 Sep;17(9):2922-31.
pubmed_id:10561372
4:
reference_text:Vogel W, Schempp W, Sigwarth I: Comparison of thymidine, fluorodeoxyuridine, hydroxyurea, and methotrexate blocking at the G1/S phase transition of the cell cycle, studied by replication patterns. Hum Genet. 1978 Dec 18;45(2):193-8.
pubmed_id:153886
5:
reference_text:Schill WB, Miska W: Possible effects of the kallikrein-kinin system on male reproductive functions. Andrologia. 1992 Mar-Apr;24(2):69-75.
pubmed_id:1318646
6:
reference_text:Grinlinton FM, Skinner MA, Birchall NM, Tan PL: Gamma delta + T cells from patients with psoriatic and rheumatoid arthritis respond to streptococcal antigen. J Rheumatol. 1993 Jun;20(6):982-7.
pubmed_id:8350335
7:
reference_text:Schulz CA, Mehta MP, Badie B, McGinn CJ, Robins HI, Hayes L, Chappell R, Volkman J, Binger K, Arzoomanian R, Simon K, Alberti D, Feierabend C, Tutsch KD, Kunugi KA, Wilding G, Kinsella TJ: Continuous 28-day iododeoxyuridine infusion and hyperfractionated accelerated radiotherapy for malignant glioma: a phase I clinical study. Int J Radiat Oncol Biol Phys. 2004 Jul 15;59(4):1107-15.
pubmed_id:15234045
8:
reference_text:Isoda K, Kim H, Hamamoto Y: A study on the mesothelial cell kinetics in pleural effusions by DNA cytophotometry and autoradiography with tritiated thymidine. Acta Pathol Jpn. 1984 Jul;34(4):775-83.
pubmed_id:6485796
9:
reference_text:Ashkenazi S, Cleary KR, Pickering LK, Murray BE, Cleary TG: The association of Shiga toxin and other cytotoxins with the neurologic manifestations of shigellosis. J Infect Dis. 1990 May;161(5):961-5.
pubmed_id:2324546
10:
reference_text:Abelson HT, Fosburg MT, Beardsley GP, Goorin AM, Gorka C, Link M, Link D: Methotrexate-induced renal impairment: clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine. J Clin Oncol. 1983 Mar;1(3):208-16.
pubmed_id:6607976
11:
reference_text:Svendsen LB, Stener Jorgensen F, Hart Hansen O, Johansen A, Horn T, Larsen JK: Influence of the prostaglandin E1 analogue Rioprostil on the human gastric mucosa. Digestion. 1987;37(1):29-34.
pubmed_id:3111919