人类代谢组数据库

版本

5.0

创建日期

2005-11-16 15:48:42 UTC

更新日期

2020-11-09 23:13:10 UTC

登录号

HMDB0000271

地位

quantified

二级访问

HMDB00271

名称

Sarcosine

描述

Sarcosine is the N-methyl derivative of glycine. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine. Sarcosine is a natural amino acid found in muscles and other body tissues. In the laboratory it may be synthesized from chloroacetic acid and methylamine. Sarcosine is naturally found in the metabolism of choline to glycine. Sarcosine is sweet to the taste and dissolves in water. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other applications. Sarcosine is ubiquitous in biological materials and is present in such foods as egg yolks, turkey, ham, vegetables, legumes, etc. Sarcosine is formed from dietary intake of choline and from the metabolism of methionine, and is rapidly degraded to glycine. Sarcosine has no known toxicity, as evidenced by the lack of phenotypic manifestations of sarcosinemia, an inborn error of sarcosine metabolism. Sarcosinemia can result from severe folate deficiency because of the folate requirement for the conversion of sarcosine to glycine (Wikipedia). Sarcosine has recently been identified as a biomarker for invasive prostate cancer. It was found to be greatly increased during prostate cancer progression to metastasis and could be detected in urine. Sarcosine levels were also increased in invasive prostate cancer cell lines relative to benign prostate epithelial cells (PMID: 19212411).

同义词

1:(Methylamino)acetic acid

2:(Methylamino)ethanoic acid

3:L-Sarcosine

4:MeGly

5:Methylaminoacetic acid

6:N-Methylaminoacetic acid

7:N-Methylglycine

8:Sar

9:Sarcosinic acid

10:(Methylamino)acetate

11:(Methylamino)ethanoate

12:Methylaminoacetate

13:N-Methylaminoacetate

14:Sarcosinate

15:(Methylamino)-acetate

16:(Methylamino)-acetic acid

17:Methylglycine

18:N-Methyl-glycine

19:Sarcosin

20:Sodium sarcosinate

21:Magnesium sarcosylate

22:Sarcosinate, sodium

23:Sarcosine hydrochloride

24:Sarcosylate, magnesium

25:N Methylglycine

26:Sarcosine monosodium salt

化学式

C3H7NO2

平均分子量

89.0932

等位分子量

89.047678473

化学名称

2-(methylamino)acetic acid

传统名称

sarcosine

CAS 登记号

107-97-1

代谢物结构字符串

CNCC(O)=O

inchi标识符

InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)

印记键

FSYKKLYZXJSNPZ-UHFFFAOYSA-N

分类学

description: belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).

description:Alpha amino acids

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Carboxylic acids and derivatives

sub_class:Amino acids, peptides, and analogues

molecular_framework:Aliphatic acyclic compounds

1:Amino acids

2:Carbonyl compounds

3:Carboxylic acids

4:Dialkylamines

5:Hydrocarbon derivatives

6:Monocarboxylic acids and derivatives

7:Organic oxides

8:Organopnictogen compounds

9:Aliphatic acyclic compound

10:Alpha-amino acid

11:Amine

12:Amino acid

13:Carbonyl group

14:Carboxylic acid

15:Hydrocarbon derivative

16:Monocarboxylic acid or derivatives

17:Organic nitrogen compound

18:Organic oxide

19:Organic oxygen compound

20:Organonitrogen compound

21:Organooxygen compound

22:Organopnictogen compound

23:Secondary aliphatic amine

24:Secondary amine

25:N-alkylglycine

26:N-methyl-amino acid

27:N-methylglycines

本体论

term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Cardiac disorders

definition:Any disorder that affects the heart.

parent_id:7695

***level:4

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Skin irritation

definition:

parent_id:7717

***level:4

type:child

term:Eye irritation

definition:

parent_id:7717

***level:4

type:child

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Parenteral

definition:Chemical exposure via the a route other than the alimentary canal.

parent_id:7743

**level:3

type:parent

term:Ocular

definition:Chemical exposure by contact with the exposed surface oft the eye.

parent_id:7745

***level:4

type:child

synonym:Eye contact

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:Muscle

definition:A fibrous soft tissue with the ability to contract to produce force and motion. (nci).

parent_id:7729

***level:4

type:child

term:Skeletal muscle

definition:Striated muscles that are under voluntary control of the organism. they are connected at either or both ends to a bone and are utilized for locomotion and other movements. (nci).

parent_id:7729

***level:4

type:child

synonym:Striated muscle

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Peroxisome

definition:A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. (Gene Ontology).

parent_id:7730

***level:4

type:child

synonym:Peroxisome vesicle

synonym:Peroxisomal

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

状态

Solid

实验性质

kind:water_solubility

value:300.0 mg/mL

source:

kind:logp

value:-2.78

source:HANSCH,C ET AL. (1995)

kind:melting_point

value:208 °C

source:

预测性质

kind:logp

value:-3.06

source:ALOGPS

kind:logs

value:0.54

source:ALOGPS

kind:solubility

value:308 g/L

source:ALOGPS

kind:logp

value:-3.2

source:ChemAxon

kind:pka_strongest_acidic

value:2.06

source:ChemAxon

kind:pka_strongest_basic

value:10.35

source:ChemAxon

kind:iupac

value:2-(methylamino)acetic acid

source:ChemAxon

kind:average_mass

value:89.0932

source:ChemAxon

kind:mono_mass

value:89.047678473

source:ChemAxon

10:

kind:smiles

value:CNCC(O)=O

source:ChemAxon

11:

kind:formula

value:C3H7NO2

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)

source:ChemAxon

13:

kind:inchikey

value:FSYKKLYZXJSNPZ-UHFFFAOYSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:49.33

source:ChemAxon

15:

kind:refractivity

value:20.78

source:ChemAxon

16:

kind:polarizability

value:8.66

source:ChemAxon

17:

kind:rotatable_bond_count

value:2

source:ChemAxon

18:

kind:acceptor_count

value:3

source:ChemAxon

19:

kind:donor_count

value:2

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

type:Specdb::EiMs

spectrum_id:880

type:Specdb::NmrTwoD

spectrum_id:1011

type:Specdb::NmrTwoD

spectrum_id:1250

type:Specdb::CMs

spectrum_id:507

type:Specdb::CMs

spectrum_id:508

type:Specdb::CMs

spectrum_id:923

type:Specdb::CMs

spectrum_id:20878

type:Specdb::CMs

spectrum_id:30021

type:Specdb::CMs

spectrum_id:30687

10:

type:Specdb::CMs

spectrum_id:30860

11:

type:Specdb::CMs

spectrum_id:31110

12:

type:Specdb::CMs

spectrum_id:32285

13:

type:Specdb::CMs

spectrum_id:37395

14:

type:Specdb::CMs

spectrum_id:146150

15:

type:Specdb::NmrOneD

spectrum_id:1224

16:

type:Specdb::NmrOneD

spectrum_id:1307

17:

type:Specdb::NmrOneD

spectrum_id:2114

18:

type:Specdb::NmrOneD

spectrum_id:2807

19:

type:Specdb::NmrOneD

spectrum_id:143250

20:

type:Specdb::NmrOneD

spectrum_id:143251

21:

type:Specdb::NmrOneD

spectrum_id:143252

22:

type:Specdb::NmrOneD

spectrum_id:143253

23:

type:Specdb::NmrOneD

spectrum_id:143254

24:

type:Specdb::NmrOneD

spectrum_id:143255

25:

type:Specdb::NmrOneD

spectrum_id:143256

26:

type:Specdb::NmrOneD

spectrum_id:143257

27:

type:Specdb::NmrOneD

spectrum_id:143258

28:

type:Specdb::NmrOneD

spectrum_id:143259

29:

type:Specdb::NmrOneD

spectrum_id:143260

30:

type:Specdb::NmrOneD

spectrum_id:143261

31:

type:Specdb::NmrOneD

spectrum_id:143262

32:

type:Specdb::NmrOneD

spectrum_id:143263

33:

type:Specdb::NmrOneD

spectrum_id:143264

34:

type:Specdb::NmrOneD

spectrum_id:143265

35:

type:Specdb::NmrOneD

spectrum_id:143266

36:

type:Specdb::NmrOneD

spectrum_id:143267

37:

type:Specdb::NmrOneD

spectrum_id:143268

38:

type:Specdb::NmrOneD

spectrum_id:143269

39:

type:Specdb::NmrOneD

spectrum_id:166453

40:

type:Specdb::MsMs

spectrum_id:472

41:

type:Specdb::MsMs

spectrum_id:473

42:

type:Specdb::MsMs

spectrum_id:474

43:

type:Specdb::MsMs

spectrum_id:3885

44:

type:Specdb::MsMs

spectrum_id:3886

45:

type:Specdb::MsMs

spectrum_id:3887

46:

type:Specdb::MsMs

spectrum_id:3888

47:

type:Specdb::MsMs

spectrum_id:3889

48:

type:Specdb::MsMs

spectrum_id:3890

49:

type:Specdb::MsMs

spectrum_id:3891

50:

type:Specdb::MsMs

spectrum_id:3892

51:

type:Specdb::MsMs

spectrum_id:7130

52:

type:Specdb::MsMs

spectrum_id:7131

53:

type:Specdb::MsMs

spectrum_id:7132

54:

type:Specdb::MsMs

spectrum_id:13802

55:

type:Specdb::MsMs

spectrum_id:13803

56:

type:Specdb::MsMs

spectrum_id:13804

57:

type:Specdb::MsMs

spectrum_id:438428

58:

type:Specdb::MsMs

spectrum_id:438429

59:

type:Specdb::MsMs

spectrum_id:438430

60:

type:Specdb::MsMs

spectrum_id:446941

61:

type:Specdb::MsMs

spectrum_id:446942

62:

type:Specdb::MsMs

spectrum_id:446943

63:

type:Specdb::MsMs

spectrum_id:446944

64:

type:Specdb::MsMs

spectrum_id:446945

光谱

生物学性质

cellular:(1):Extracellular

cellular:(2):Mitochondria

cellular:(3):Peroxisome

biospecimen:(1):Blood

biospecimen:(2):Cerebrospinal Fluid (CSF)

biospecimen:(3):Feces

biospecimen:(4):Saliva

biospecimen:(5):Urine

tissue:(1):Prostate

tissue:(2):Skeletal Muscle

[1]:

name:3-Phosphoglycerate dehydrogenase deficiency

smpdb_id:SMP00721

kegg_map_id:

[2]:

name:Cystathionine Beta-Synthase Deficiency

smpdb_id:SMP00177

kegg_map_id:

[3]:

name:Dihydropyrimidine Dehydrogenase Deficiency (DHPD)

smpdb_id:SMP00179

kegg_map_id:

[4]:

name:Dimethylglycine Dehydrogenase Deficiency

smpdb_id:SMP00242

kegg_map_id:

[5]:

name:Dimethylglycine Dehydrogenase Deficiency

smpdb_id:SMP00484

kegg_map_id:

[6]:

name:Glycine N-methyltransferase Deficiency

smpdb_id:SMP00222

kegg_map_id:

[7]:

name:Glycine, serine and threonine metabolism

smpdb_id:

kegg_map_id:map00260

[8]:

name:Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type

smpdb_id:SMP00570

kegg_map_id:

[9]:

name:Hyperglycinemia, non-ketotic

smpdb_id:SMP00485

kegg_map_id:

[10]:

name:Hypermethioninemia

smpdb_id:SMP00341

kegg_map_id:

[11]:

name:Methionine Adenosyltransferase Deficiency

smpdb_id:SMP00221

kegg_map_id:

[12]:

name:Methionine Metabolism

smpdb_id:SMP00033

kegg_map_id:map00270

[13]:

name:Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)

smpdb_id:SMP00340

kegg_map_id:

[14]:

name:Non Ketotic Hyperglycinemia

smpdb_id:SMP00223

kegg_map_id:

[15]:

name:S-Adenosylhomocysteine (SAH) Hydrolase Deficiency

smpdb_id:SMP00214

kegg_map_id:

[16]:

name:Sarcosine Oncometabolite Pathway

smpdb_id:SMP02313

kegg_map_id:

[17]:

name:Sarcosinemia

smpdb_id:SMP00244

kegg_map_id:

正常浓度

biospecimen:Blood

concentration_value:0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:1.4 +/- 0.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:<0.001

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:<10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

10:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

11:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

12:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

13:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

14:

biospecimen:Saliva

concentration_value:10.42 +/- 4.19

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

15:

biospecimen:Saliva

concentration_value:>10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

16:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

17:

biospecimen:Saliva

concentration_value:2.53 +/- 1.74

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

18:

biospecimen:Saliva

concentration_value:3.48 +/- 2.23

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

19:

biospecimen:Saliva

concentration_value:4.15 +/- 2.02

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

20:

biospecimen:Urine

concentration_value:<0.23

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

21:

biospecimen:Urine

concentration_value:<0.00100

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

22:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

23:

biospecimen:Urine

concentration_value:0.47

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

24:

biospecimen:Urine

concentration_value:0.55-9.98

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

25:

biospecimen:Urine

concentration_value:1.74(0.77-11.36)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

26:

biospecimen:Urine

concentration_value:2.28(0.51-4.79)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

27:

biospecimen:Urine

concentration_value:<0.34

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Not Specified

subject_condition:Normal

28:

biospecimen:Urine

concentration_value:<0.34

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

29:

biospecimen:Urine

concentration_value:0.24-0.34

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

30:

biospecimen:Urine

concentration_value:5.946 +/- 10.638

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

31:

biospecimen:Urine

concentration_value:<8.48

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

32:

biospecimen:Urine

concentration_value:<1.467

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

33:

biospecimen:Urine

concentration_value:<1.467

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

34:

biospecimen:Urine

concentration_value:2.9 (0.5-5.4)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Urine

concentration_value:<1.36

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

36:

biospecimen:Urine

concentration_value:1.6 (0.2-9.4)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

37:

biospecimen:Urine

concentration_value:<1.018

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

38:

biospecimen:Urine

concentration_value:0.25-0.31

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

39:

biospecimen:Urine

concentration_value:<50

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

40:

biospecimen:Urine

concentration_value:<56.5

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

41:

biospecimen:Urine

concentration_value:1.35 +/- 1.21

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

42:

biospecimen:Urine

concentration_value:5-25

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

异常浓度

biospecimen:Blood

concentration_value:300.0 (80.0-603.0)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Sarcosinemia

biospecimen:Blood

concentration_value:0

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Dimethylglycinuria

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:gastric cancer

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

biospecimen:Blood

concentration_value:654.1

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Female

patient_information:Sarcosinemia

biospecimen:Blood

concentration_value:200-300

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Sarcosinemia

biospecimen:Blood

concentration_value:238-379

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Sarcosinemia

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:5-17

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Sarcosinemia

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:7-12

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Sarcosinemia

10:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

11:

biospecimen:Saliva

concentration_value:3.37 +/- 1.84

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

12:

biospecimen:Saliva

concentration_value:20.53 +/- 27.29

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

13:

biospecimen:Saliva

concentration_value:4.84 +/- 3.39

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

14:

biospecimen:Urine

concentration_value:0

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Dimethylglycinuria

15:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Prostate cancer

16:

biospecimen:Urine

concentration_value:12.028 +/- 27.256

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

17:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

18:

biospecimen:Urine

concentration_value:361.333

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Sarcosinemia

19:

biospecimen:Urine

concentration_value:2703.95

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Female

patient_information:Sarcosinemia

20:

biospecimen:Urine

concentration_value:631-1214

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Sarcosinemia

疾病参考

name:Sarcosinemia

omim_id:268900

[1]:

reference_text:Levy HL, Coulombe JT, Benjamin R: Massachusetts Metabolic Disorders Screening Program: III. Sarcosinemia. Pediatrics. 1984 Oct;74(4):509-13.

pubmed_id:6207480

[2]:

reference_text:Sewell AC, Krille M, Wilhelm I: Sarcosinaemia in a retarded, amaurotic child. Eur J Pediatr. 1986 Feb;144(5):508-10.

pubmed_id:2420598

[3]:

reference_text:Benarrosh A, Garnotel R, Henry A, Arndt C, Gillery P, Motte J, Bakchine S: A young adult with sarcosinemia. No benefit from long duration treatment with memantine. JIMD Rep. 2013;9:93-96. doi: 10.1007/8904_2012_185. Epub 2012 Oct 21.

pubmed_id:23430553

[4]:

reference_text:Meissner T, Mayatepek E: Sarcosinaemia in a patient with severe progressive neurological damage and hypertrophic cardiomyopathy. J Inherit Metab Dis. 1997 Sep;20(5):717-8.

pubmed_id:9323574

[5]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

[6]:

reference_text:In: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. eds. The Online Metabolic and Molecular Bases of Inherited Disease New York, NY

pubmed_id:

name:Colorectal cancer

omim_id:114500

[1]:

reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.

pubmed_id:7482520

[2]:

reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.

pubmed_id:19006102

[3]:

reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.

pubmed_id:23940645

[4]:

reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.

pubmed_id:24424155

[5]:

reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.

pubmed_id:20156336

[6]:

reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.

pubmed_id:19678709

[7]:

reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.

pubmed_id:22148915

[8]:

reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.

pubmed_id:25105552

[9]:

reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.

pubmed_id:21773981

[10]:

reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.

pubmed_id:25037050

[11]:

reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.

pubmed_id:27015276

[12]:

reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.

pubmed_id:27107423

[13]:

reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.

pubmed_id:27275383

[14]:

reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.

pubmed_id:28587349

[15]:

reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984

name:Stomach cancer

omim_id:137215

[1]:

reference_text:Higashijima H, Ichimiya H, Nakano T, Yamashita H, Kuroki S, Satoh H, Chijiiwa K, Tanaka M: Deconjugation of bilirubin accelerates coprecipitation of cholesterol, fatty acids, and mucin in human bile--in vitro study. J Gastroenterol. 1996 Dec;31(6):828-35.

pubmed_id:9027647

[2]:

pubmed_id:7482520

[3]:

reference_text:Song H, Peng JS, Dong-Sheng Y, Yang ZL, Liu HL, Zeng YK, Shi XP, Lu BY: Serum metabolic profiling of human gastric cancer based on gas chromatography/mass spectrometry. Braz J Med Biol Res. 2012 Jan;45(1):78-85. Epub 2011 Nov 25.

pubmed_id:22124703

[4]:

reference_text:Yu L, Aa J, Xu J, Sun M, Qian S, Cheng L, Yang S, Shi R: Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry. J Gastroenterol Hepatol. 2011 Aug;26(8):1290-7. doi: 10.1111/j.1440-1746.2011.06724.x.

pubmed_id:21443661

[5]:

pubmed_id:21773981

name:Alzheimer's disease

omim_id:104300

[1]:

reference_text:Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10.

pubmed_id:17031479

[2]:

reference_text:Selley ML, Close DR, Stern SE: The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging. 2002 May-Jun;23(3):383-8.

pubmed_id:11959400

[3]:

reference_text:Shetty HU, Holloway HW, Schapiro MB: Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem. 1996 Feb;42(2):298-302.

pubmed_id:8595727

[4]:

reference_text:Jia JP, Jia JM, Zhou WD, Xu M, Chu CB, Yan X, Sun YX: Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. Chin Med J (Engl). 2004 Aug;117(8):1161-4.

pubmed_id:15361288

[5]:

reference_text:Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4.

pubmed_id:9693263

[6]:

reference_text:Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J: Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303.

pubmed_id:15465626

[7]:

reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.

pubmed_id:15061359

[8]:

reference_text:Raskind MA, Peskind ER, Holmes C, Goldstein DS: Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Biol Psychiatry. 1999 Sep 15;46(6):756-65.

pubmed_id:10494443

[9]:

reference_text:Lovell MA, Markesbery WR: Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch Neurol. 2001 Mar;58(3):392-6.

pubmed_id:11255442

[10]:

reference_text:Bar KJ, Franke S, Wenda B, Muller S, Kientsch-Engel R, Stein G, Sauer H: Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia. Neurobiol Aging. 2003 Mar-Apr;24(2):333-8.

pubmed_id:12498967

[11]:

reference_text:Serot JM, Barbe F, Arning E, Bottiglieri T, Franck P, Montagne P, Nicolas JP: Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1585-7.

pubmed_id:16227558

[12]:

reference_text:Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm (Vienna). 1998;105(4-5):479-88.

pubmed_id:9720975

[13]:

reference_text:Molina JA, Jimenez-Jimenez FJ, Hernanz A, Fernandez-Vivancos E, Medina S, de Bustos F, Gomez-Escalonilla C, Sayed Y: Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease. J Neural Transm (Vienna). 2002 Jul;109(7-8):1035-44.

pubmed_id:12111441

[14]:

reference_text:Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203.

pubmed_id:16244393

[15]:

reference_text:Kristensen MO, Gulmann NC, Christensen JE, Ostergaard K, Rasmussen K: Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand. 1993 Jun;87(6):475-81.

pubmed_id:8356878

[16]:

reference_text:Abe T, Tohgi H, Isobe C, Murata T, Sato C: Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.

pubmed_id:12391605

[17]:

reference_text:Reichman ME, Judd JT, Longcope C, Schatzkin A, Clevidence BA, Nair PP, Campbell WS, Taylor PR: Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst. 1993 May 5;85(9):722-7.

pubmed_id:8478958

[18]:

reference_text:Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T: Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011 Apr 15;303(1-2):95-9. doi: 10.1016/j.jns.2011.01.003. Epub 2011 Feb 2.

pubmed_id:21292280

[19]:

reference_text:Motawaj M, Peoc'h K, Callebert J, Arrang JM: CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease. J Alzheimers Dis. 2010;22(3):861-71. doi: 10.3233/JAD-2010-100381.

pubmed_id:20858978

[20]:

reference_text:Smach MA, Jacob N, Golmard JL, Charfeddine B, Lammouchi T, Ben Othman L, Dridi H, Bennamou S, Limem K: Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study. Eur Neurol. 2011;65(5):270-8. doi: 10.1159/000326301. Epub 2011 Apr 8.

pubmed_id:21474939

[21]:

reference_text:Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, Blom H, Stoffel-Wagner B, Kolsch H, Weller M, Jessen F: S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 2010;7(6):373-8. doi: 10.1159/000309657. Epub 2010 Jun 3.

pubmed_id:20523031

[22]:

reference_text:Rosler N, Wichart I, Jellinger KA: Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients. J Neural Transm (Vienna). 2001;108(2):231-46.

pubmed_id:11314776

[23]:

reference_text:Sunderland T, Berrettini WH, Molchan SE, Lawlor BA, Martinez RA, Vitiello B, Tariot PN, Cohen RM: Reduced cerebrospinal fluid dynorphin A1-8 in Alzheimer's disease. Biol Psychiatry. 1991 Jul 1;30(1):81-7.

pubmed_id:1716470

[24]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

name:Frontotemporal dementia

omim_id:600274

[1]:

pubmed_id:23857558

name:Lewy body disease

omim_id:

[1]:

pubmed_id:23857558

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

name:Prostate cancer

omim_id:176807

[1]:

reference_text:Nyman DW, Suzanne Stratton M, Kopplin MJ, Dalkin BL, Nagle RB, Jay Gandolfi A: Selenium and selenomethionine levels in prostate cancer patients. Cancer Detect Prev. 2004;28(1):8-16.

pubmed_id:15041072

[2]:

reference_text:Key TJ, Appleby PN, Allen NE, Travis RC, Roddam AW, Jenab M, Egevad L, Tjonneland A, Johnsen NF, Overvad K, Linseisen J, Rohrmann S, Boeing H, Pischon T, Psaltopoulou T, Trichopoulou A, Trichopoulos D, Palli D, Vineis P, Tumino R, Berrino F, Kiemeney L, Bueno-de-Mesquita HB, Quiros JR, Gonzalez CA, Martinez C, Larranaga N, Chirlaque MD, Ardanaz E, Stattin P, Hallmans G, Khaw KT, Bingham S, Slimani N, Ferrari P, Rinaldi S, Riboli E: Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study. Am J Clin Nutr. 2007 Sep;86(3):672-81.

pubmed_id:17823432

[3]:

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

[4]:

reference_text:Puah CM, Williams G, Ghanadian R: Urinary unconjugated 5 alpha-androstane-3 alpha, 17 beta-diol in patients with prostatic tumours. Urol Res. 1982;10(2):81-4.

pubmed_id:6180540

[5]:

reference_text:Thysell E, Surowiec I, Hornberg E, Crnalic S, Widmark A, Johansson AI, Stattin P, Bergh A, Moritz T, Antti H, Wikstrom P: Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol. PLoS One. 2010 Dec 3;5(12):e14175. doi: 10.1371/journal.pone.0014175.

pubmed_id:21151972

[6]:

reference_text:Soliman LC, Hui Y, Hewavitharana AK, Chen DD: Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry. J Chromatogr A. 2012 Dec 7;1267:162-9. doi: 10.1016/j.chroma.2012.07.021. Epub 2012 Jul 14.

pubmed_id:22824219

[7]:

reference_text:Madu CO, Lu Y: Novel diagnostic biomarkers for prostate cancer. J Cancer. 2010 Oct 6;1:150-77.

pubmed_id:20975847

name:Dimethylglycine Dehydrogenase Deficiency

omim_id:605850

[1]:

reference_text:Moolenaar SH, Poggi-Bach J, Engelke UF, Corstiaensen JM, Heerschap A, de Jong JG, Binzak BA, Vockley J, Wevers RA: Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study. Clin Chem. 1999 Apr;45(4):459-64.

pubmed_id:10102904

KEGG数据库编号

C00213

DrugBank数据库编号

DB12519

foodb数据库编号

FDB004048

ChemSpider数据库编号

1057

公共化学化合物编号

1088

PDB数据库编号

生物利益的化学实体数据库编号

15611

knapsack数据库编号

维基百科编号

Sarcosine

代谢途径的数据库编号

SARCOSINE

苯酚资源管理器化合物数据库编号

比格数据库编号

34275

梅林编号

虚拟机身份证编号

SARCS

fbonto数据库编号

综合参考

Cipens, G.; Slavinska, V.; Sile, D.; Kreile, D.; Strautina, A.; Krikis, A.; Gutmanis, A. Synthesis of sarcosine and its use. Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija (1986), (5), 515-24.

一般参考

protein_accession:HMDBP00122

name:Peroxisomal sarcosine oxidase

uniprot_id:Q9P0Z9

gene_name:PIPOX

protein_type:Unknown

protein_accession:HMDBP00203

name:Dimethylglycine dehydrogenase, mitochondrial

uniprot_id:Q9UI17

gene_name:DMGDH

protein_type:Unknown

protein_accession:HMDBP00403

name:Glycine N-methyltransferase

uniprot_id:Q14749

gene_name:GNMT

protein_type:Unknown

protein_accession:HMDBP00793

name:Sarcosine dehydrogenase, mitochondrial

uniprot_id:Q9UL12

gene_name:SARDH

protein_type:Unknown

protein_accession:HMDBP10881

name:Proton-coupled amino acid transporter 2

uniprot_id:Q495M3

gene_name:SLC36A2

protein_type:Unknown

蛋白质结合

pubmed_id:19212411

reference_text:Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38.

pubmed_id:2026685

reference_text:Boulat O, Gradwohl M, Matos V, Guignard JP, Bachmann C: Organic acids in the second morning urine in a healthy Swiss paediatric population. Clin Chem Lab Med. 2003 Dec;41(12):1642-58.

pubmed_id:14708889

reference_text:Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

pubmed_id:12097436

reference_text:Akare S, Martinez JD: Bile acid induces hydrophobicity-dependent membrane alterations. Biochim Biophys Acta. 2005 Jun 15;1735(1):59-67.

pubmed_id:15951237

reference_text:Lim DS, Roberts R, Marian AJ: Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes. J Am Coll Cardiol. 2001 Oct;38(4):1175-80.

pubmed_id:11583900

reference_text:Bales JR, Sadler PJ, Nicholson JK, Timbrell JA: Urinary excretion of acetaminophen and its metabolites as studied by proton NMR spectroscopy. Clin Chem. 1984 Oct;30(10):1631-6.

pubmed_id:6206966

reference_text:Heil M, Podebrad F, Prado E, Beck T, Mosand A, Sewell AC, Bohles H, Lehnert W: Enantioselective analysis of ketone bodies in patients with beta-ketothiolase deficiency, medium-chain acyl coenzyme A dehydrogenase deficiency and ketonemic vomiting. J Chromatogr B Biomed Sci Appl. 2000 Mar 10;739(2):313-24.

pubmed_id:10755375

reference_text:Kang ES, Seyer J, Todd TA, Herrera C: Variability in the phenotypic expression of abnormal sarcosine metabolism in a family. Hum Genet. 1983;64(1):80-5.

pubmed_id:6192074

10:

reference_text:Vallera DA, Todhunter DA, Kuroki DW, Shu Y, Sicheneder A, Chen H: A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma. Clin Cancer Res. 2005 May 15;11(10):3879-88.

pubmed_id:15897589

11:

reference_text:Hitomi J, Yamaguchi K, Kikuchi Y, Kimura T, Maruyama K, Nagasaki K: A novel calcium-binding protein in amniotic fluid, CAAF1: its molecular cloning and tissue distribution. J Cell Sci. 1996 Apr;109 ( Pt 4):805-15.

pubmed_id:8718672

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